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You are here: Home / Events / Dott. Bénédicte Chazaud: "Macrophages in the inflammatory response - example of skeletal muscle regeneration"

Dott. Bénédicte Chazaud: "Macrophages in the inflammatory response - example of skeletal muscle regeneration"

Benedicte Chazaud Institut NeuroMyoGène UMR CNRS 5310 – INSERM U1217 Universite Claude Bernard Lyon 1 8 Avenue Rockefeller F-69008 Lyon benedicte.chazaud@inserm.fr www.musclestem.com www.inmg.fr
When Oct 21, 2019
from 12:00 PM to 01:30 PM
Where CNR Conference Room
Contact Name
Contact Phone +39 081 6132 718
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Skeletal muscle is a highly adaptable tissue with well-known sensitivities to environmental cues such as growth factors, cytokines, nutrients and mechanical loading. Moreover, adult skeletal muscle exhibits great plasticity and has the unique capacity to regenerate after injury, due to the main muscle stem cells, the satellite cells. Satellite cells, and their progeny, the myogenic precursor cells, must develop proper interactions with their direct environment to ensure muscle regeneration and replenishment of the stem cell pool. The aim of our research is to understand the role of the environment (non-myogenic cells and molecular structures) in the regulation of skeletal muscle regeneration. Myogenic cell environment includes inflammatory cells and particularly macrophages, vessel cells (endothelial and peri-endothelial cells) and interstitial cells. Moreover, we aim at understanding the interactions between myogenic cells and their environment in various pathological situations.

  • § Juban G […], Chazaud B. AMPK activation regulates LTBP4-dependent TGFbeta1 secretion by pro-inflammatory macrophages and controls fibrosis in Duchenne Muscular Dystrophy. Cell Rep 2018 25: 2163-2176.
  • § Le Moal  […], Chazaud B, Mounier R. Macrophage-derived superoxide production and antioxidant response following skeletal muscle injury. Free Radical Biol Med. 2018 120:33-40.
  • § Gitiaux […], Chazaud B. Myogenic progenitor cells exhibit IFN type I-driven pro-angiogenic properties and molecular signature during juvenile dermatomyositis. Arthritis Rheumatol. 2018 70:134-45.
  • § Latroche C […], Chazaud B. Coupling between myogenesis and angiogenesis during skeletal muscle regeneration is stimulated by restorative macrophages. Stem Cell Rep. 2017 9:2018-33.
  • § Theret M […], Chazaud B, Mounier R. AMPKα1-LDH pathway regulates muscle stem cell self-renewal by controlling metabolic homeostasis. EMBO J. 2017 36:1946-62.
  • § Varga T […], Chazaud B*, Nagy L*. Macrophage PPARγ, a lipid activated transcription factor controls the growth factor GDF3 and skeletal muscle Regeneration. Immunity 2016 45:1038-51. $* equal contributions.
  • § Varga T […], Chazaud B. Highly dynamic transcriptional signature of distinct macrophage subsets during sterile inflammation, resolution and tissue repair. J Immunol 2016 196:4771-82.
  • § Mounier R […], Chazaud B. AMPKα1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration. Cell Metab 2013 18:251-64.
  • § Saclier M […], Chazaud B. Differentially activated macrophages orchestrate myogenic precursor cell fate during human skeletal muscle regeneration. Stem Cells 2013 31:384-96.
  • § Abou-Khalil R […], Chazaud B. Autocrine and paracrine Angiopoietin 1/Tie-2 signalling promotes muscle satellite cell self-renewal. Cell Stem Cell 2009 5:298-309.
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