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You are here: Home / Events / IGB-IBBR-IEOS Joint Seminar - Prof. Ales Iglic: "Membrane tubular protrusions and tunneling nanotubes"

IGB-IBBR-IEOS Joint Seminar - Prof. Ales Iglic: "Membrane tubular protrusions and tunneling nanotubes"

Professor, Faculty of Electrical Engineering, University of Ljubljana, Slovenia Head of the Laboratory of Biophysics
When Feb 26, 2019
Where CNR Conference Room
Contact Name
Contact Phone 081 6132 294
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Abstract

We present a physical mechanism that may explain experimentally observed  tubular and spherical budding of  biological  membrane. The proposed mechanism is based on the energetically favourable self-assembly of membrane nanodomains into larger membrane domains forming  spherical, tubular or undulated tubular  membrane protrusions.  The suggested mechanism of  growth and  stabilization of  membrane protrusions by coupling of the local membrane shape and the lateral density of the membrane constituents (nanodomains) is also one of the mechanisms relevant for the formation and stabilization of  tunneling nanotubes that connect cells, and could be important in intracellular and intercellular transport and communication.


Publications

1. 5. P. Kurioz, L. Mesarec, A. Iglič, S. Kralj: Assembling of topological defects at neck-shaped  membrane parts, Phys. Status Solidi A, 1800722, 2019.

2. L. Mesarec, W. Góźdź, S. Kralj, M. Fošnarič, S. Penič, V. Kralj Iglič, A. Iglič: On the role of external force of actin filaments in the formation of tubular protrusions of closed membrane shapes with anisotropic membrane components, Eur. Biophys. J., 46: 705-718, 2017

3.L. Mesarec, W. Góźdź, V. Kralj Iglič, S. Kralj, A. Iglič: Closed membrane shapes with attached BAR domains subject to external force of actin filaments, Colloids and Surfaces B: Biointerfaces, 141: 132–140, 2016.

4. N. Bobrovska, W. Góźdź, V. Kralj-Iglič, A. Iglič: On the role of anisotropy of membrane components in formation and stabilization of tubular structures in multicomponent membranes, PLOS ONE, 8 e73941, 2013.

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