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You are here: Home / Events / Prof. Frédéric Relaix: “Molecular mechanisms regulating muscle stem cell quiescence and activation"

Prof. Frédéric Relaix: “Molecular mechanisms regulating muscle stem cell quiescence and activation"

The Mondor Institute of Biomedical Research IMRB, Inserm U955 – University Paris Est Créteil, UPEC France
When Apr 15, 2019
from 12:00 PM to 01:30 PM
Where CNR Conference Room
Contact Name
Contact Phone +39 0871 6132 718
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Frédéric Relaix has been studying for 20 years skeletal muscle formation and Muscle Stem Cells regulation and described for the first time the stem cell source for skeletal muscle formation (Relaix F Nature 2005). F.R. is vice-­‐dean for research and head of the MD/PhD programme at UPEC faculty of medicine, director of the neuromuscular and neuropsychiatry research department at IMRB and head of a large team (>80) translational INSERM/UPEC team in the neuromuscular field that includes members with trainings ranging from basic, translational, veterinary or medical fields. His research group is interested in the molecular regulation of postnatal stem cell specification, growth arrest and quiescence, the molecular pathways and gene regulatory networks regulating muscle stem cell development, growth and aging, as well as in the cellular and molecular components of their niche and local environment, deciphering the mechanisms underlying neuromuscular maintenance and function in physiological or pathogenic conditions such as Duchenne Muscular Dystrophy, with a strong focus on muscle stem cells preclinical modeling of neuromuscular disorders, and establishment of Crispr/Cas9-­‐mediated therapy. During the last 5 years, his group received fundings from about 15 national and international agencies including PIA programmes RHU CARMMA and Labex Revive. F.R. is head of an AFM-­‐funded large strategic pole with a broad spectrum of models and expertise, including exclusive preclinical rat models for DMD, and a unique strategic position to generate preclinical tools and transfer knowledge to the clinics.

Selected Peer-­reviewed Publications (from 87 publications, 5592 citations, H-­index 35)
• five major selected peer-­reviewed publications in the scope of the current application
Machado L, Esteves de Lima J, Fabre O, Proux C, Legendre R, Szegedi A, Varet H, Ingerslev L, Barrès R, Relaix F*, Mourikis P. (2017). In situ fixation redefines quiescence and early activation of skeletal muscle stem cells, Cell Reports 21(7),1982-­‐1993. PMID: 29141227 (*corresponding author)
Chal J, Oginuma M, Al Tanoury Z, Gobert B, Sumara O, Hick A, Bousson F, Zidouni Y, Mursch C, Moncuquet P, Moncuquet P, Tassy O, Vincent S, Miyanari A, Bera A, Garnier JM, Guevara G, Hestin M, Kennedy L, Hayashi S, Drayton B, Cherrier T, Gayraud-­‐Morel B, Gussoni E, Relaix F, Tajbakhsh S, Pourquie O. (2015). Differentiation of pluripotent stem cells tomuscle fiber to model Duchenne muscular dystrophy. Nat biotechnol 33, 962-­‐969. PMID: 26237517
Relaix F, Montarras D, Zaffran S, Gayraud-­‐Morel B, Rocancourt D, Tajbakhsh S, Mansouri A, Cumano A, Buckingham M.(2006). Pax3 and Pax7 have distinct and overlapping functions in adult muscle progenitor cells. J Cell Biol 172, 91-­‐102. PMID: 16380438
Relaix F, Rocancourt D, Mansouri A, Buckingham M. (2005). A Pax3/Pax7-­‐dependent population of skeletal muscle
progenitor cells. Nature 435, 948-­‐953. PMID: 15843801
Montarras D, Morgan J, Collins C, Relaix F, Cumano A, Partridge T, Buckingham M. (2005). Direct isolation of muscle
satellite cells for skeletal muscle regeneration. Science 309, 2064-­‐2067. PMID: 16141372
• five additional publications of importance
Mademtzoglou D, Asakura Y, Borok M, Alonso-­‐Martin S, Mourikis P, Kodaka Y, Mohan A, Asakura A, Relaix F. (2018). Cellular localization of the cell cycle inhibitor Cdkn1c controls growth arrest of adult skeletal muscle stem cells. Elife 7, e33337. PMID: 30284969
Baghdadi MB, Castel D, Machado L, Fukada SI, Birk DE, Relaix F, Tajbakhsh S, Mourikis P. (2018). Notch/CollagenV/CalcR reciprocal signalling retains muscle stem cells in their niche. Nature 557(7707), 714-­‐718. PMID: 29795344
Zalc A, Rattenbach R, Auradé F, Cadot B, Relaix F. (2015). Pax3 and Pax7 play essential safeguard functions against
environmental stress-­‐induced birth defects. Dev Cell 33(1), 56-­‐66. PMID: 25800090
Ho AT, Hayashi S, Bröhl D, Auradé F, Rattenbach R, Relaix F. (2011). Neural crest cell lineage restricts skeletal muscle progenitor cell differentiation through Neuregulin1-­‐ErbB3 signaling. Dev Cell 21, 273-­‐287. PMID: 21782525
Lagha M, Brunelli S, Messina G, Cumano A, Kume T, Relaix F*, Buckingham ME*. (2009). Pax3 :Foxc2 reciprocal
repression in the somite modulates luscular versus vascular cell fate choice in multipotent progenitors. Dev Cell 17(6),
892-­‐899. PMID: 20059958 (*co-­‐senior author)

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