Skip to content. | Skip to navigation

Personal tools

This is SunRain Plone Theme

Navigation

banner8
banner18
banner2
banner11
banner6
banner16
banner5
banner10
banner13
banner7
banner3
banner1
banner9
banner0
banner12
banner15
banner4
banner14
banner17
You are here: Home / Events / Prof. Nicola Elvassore: "Patient-specific organ-on-chip"

Prof. Nicola Elvassore: "Patient-specific organ-on-chip"

Associate Professor Department of Industrial Engineering University of Padova Via Marzolo 9 35131 Padova, Italy Office: +39-049-827-5469 E-mail: nicola.elvassore@unipd.it
When Sep 30, 2019
from 12:00 PM to 01:25 PM
Where CNR Conference Room
Contact Name
Contact Phone 081 6132 357
Add event to calendar vCal
iCal
Dr. Nicola Elvassore is Professor (since 2017) at the Department of Industrial Engineering at University of Padova, Italy; Professorial Research Associate (since 2015) at the Faculty of Pop Health Sciences, Centre for Stem Cells & Regenerative Medicine of the University College London, UK. He is furthermore Principal Investigator (since 2007) at the Venetian Institute of Molecular Medicine, Padova, Italy and Distinguished Professor-in-Residency (since 2015) at Shanghai Institute of Advanced Immunochemistry (SIAIS) of ShanghaiTech University, Shanghai, China. His work focuses on the area of stem cell engineering. He is constantly developing micro-technologies to investigate, to decipher and dissected the extrinsic networks of endogenous signals which is self-established during cellular reprogramming and programming. He is applying engineering principles for controlling the 3D self-arrangement ability of pluripotent stem cell toward tissues or organs to model human disease and predict patient-specific pathological outcomes. By coupling large-scale multiplex experimental platforms, he aims to investigate how individual heterogeneity combined with environmental signals, which are by definition oscillatory in nature, defines pathological onsets. His publication list includes over 90 papers published as articles in peer-review journals like Nature, Nature Methods and Cell.


Abstract
Organogenesis and tissue generation are complex developmental processes starting from germ layer specification and phenotypic differentiation to tissue morphogenesis. This multi-scale processes are controlled by the concerted action of biochemical and physical cues, however, the precise molecular events that integrate mechanical and biochemical signals to control developmental process are not fully known.
Biomimetic scale down of developmental processes through micro-technologies and microfluidics allows accurate control of cell culture microenvironment, of the temporal evolution of chemical gradients and of mechanical features. Shaping topological, mechanical, and soluble microenvironment will allow investigating, characterizing, dissecting, and reconstructing biological and physiological phenomena. We explored whether we could control somatic human cell reprogramming, pluripotent stem cell expansion, selective germ layer commitment and derivation of functional tissue-specific cells by tuning biomechanical and biochemical extrinsic and intrinsic cell signaling. 
The rational understanding of cell niche specification in terms of the accurate balance between extrinsic and intrinsic factors required at different developmental stages will be used for the production of iPSC-derived human autologous Organ-on-Chip, in particular, patient-specific liver-on-chip.
Filed under: