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You are here: Home / Events / Prof. Niels Geijsen: “Stem cell models of early embryogenesis”

Prof. Niels Geijsen: “Stem cell models of early embryogenesis”

Hubrecht Institute, Developmental Biology and Stem Cell Research, Utrecht University Uppsalalaan 8 Room - 3584 CT UTRECHT The Netherlands
When May 27, 2019
from 12:00 PM to 01:30 PM
Where CNR Conference Room
Contact Name
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Niels Geijsen received his PhD in Molecular Biology from Utrecht University in The Netherlands. He completed his post-doctoral training in the lab of Dr. George Daley at the Whitehead Institute for Biomedical Research where he established a method for the in vitro generation of germ cells from embryonic stem cells. In 2004, Dr. Geijsen was appointed Assistant Professor at Massachusetts General Hospital and principal faculty member of the Harvard Stem Cell Institute, where he explored the biology of pluripotent stem cells. This work lay the foundation for his current work modeling human genetic disorders.

 In 2010, Dr. Geijsen relocated his research lab to the Hubrecht Institute of the Royal Dutch Academy of Sciences in The Netherlands and was appointed Full Professor of Regenerative Medicine at Utrecht University.

 Dr. Geijsen’s lab has developed a methods for the in vitro modeling of human genetic diseases, with particular focus on genetic muscle disorders. His team has identied a novel mechanism for the introduction of native proteins into mammalian cells and has shown how this technology can be appied to introduce CRIsPR/Cas9 gene editing complexes into primary (stem) cells. This technology, called iTOP, was the basis of a biotech startum, NTrans Technologies, which he co-founded.

Pluripotent stem cells are a powerful tool to model genetic muscle diseases such as Duchenne Muscular Dystrophy and FSHD. Since the pathogenesis of many of these disorders starts during early development, Dr. Geijsen’s and his team develop stemcell-based assays to model the early stages of development in vitro. In a recent publication they demonstrate that stem cells can self-organize to form blastocyst-like structures that can be used to model early trophoblast differentiation and implantation.

Currently, Dr. Geijsen is Principal Faculty at the Hubrecht Institute of the Dutch Royal Academy of Sciences, Professor of Regenerative Medicine at Utrecht University and co-founder of NTrans Technologies.

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