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You are here: Home / Events / Prof. Richard Gibbons: "Understanding the function of the chromatin remodelling factor ATRX”

Prof. Richard Gibbons: "Understanding the function of the chromatin remodelling factor ATRX”

Professor of Clinical Genetics Hon Consultant Clinical Geneticist University of Oxford Medical Science Division United Kingdom richard.gibbons@ndcls.ox.ac.uk
When Mar 18, 2019
from 12:00 PM to 01:30 PM
Where CNR Conference Room
Contact Name
Contact Phone 081 6132 338
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I’m a Clinical Geneticist and Molecular Biologist working In the MRC Molecular Haematology Unit, in the Weatherall Institute of Medicine in Oxford. I studied Medicine and did the bulk of my training at Oxford.  Over the last 25 years I have worked to understand the role of a chromatin remodelling protein in transcriptional regulation and how, when mutated, it leads to human disease. ATRX is a member of the SWI2/SNF2 family of molecular motors which remodel chromatin by using the hydrolysis of ATP as an energy source. Germline mutations in ATRX give rise to a syndromal form of intellectual disability associated with alpha thalassaemia (ATR-X syndrome). ATR-X represents one of the best studied examples of a newly recognised class of human disease, a disease of chromatin.

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