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You are here: Home / Events / WEBINAR - Dr. Nicola Iovino: “Epigenetics in Reproductive Health"

WEBINAR - Dr. Nicola Iovino: “Epigenetics in Reproductive Health"

Max-Planck-Institute of Immunobiology and Epigenetics - Freiburg Centre for Integrative Biological Signalling Studies - email: iovino@ie.freiburg.mpg.de
When Oct 25, 2021
from 12:00 PM to 01:20 PM
Where Aula Virtuale Webinar
Contact Name
Contact Phone 081 6132 422
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Abstract:

Fertilization occurs when the two gametes, after epigenetic reprogramming, fuse to produce a totipotent zygote. Although any defects in gametes’ reprogramming can cause infertility, the mechanisms underlying this process, remain poorly understood. Our lab now focuses on understanding the epigenetic events contributing to the formation of functional gametes, to the establishment of totipotency and to the conversion of the totipotent zygote’s quiescent genome into a transcriptionally competent one.

We recently showed that H3K27me3 repressive histone mark is retained on post- meiotic oocytes and it is intergenerationally transmitted from the germline to the early embryo. The maternally inherited H3K27me3 regulates the activation of enhancers and lineage-specific genes during development. Thus, we suggest that H3K27me3 serve as a template of epigenetic memory that can be transferred through the maternal germline and instruct the developmental program of the next generation.

Bio Sketch:

Nicola Iovino studied biology in Naples, Italy, where I got an MSc in Biology in 2002 under the supervision of Prof. Roberto Di Lauro.
He then worked 3 years in industry in the Merck research laboratories in the laboratory of Riccardo Cortese, in Pomezia, Rome, before to go back to basic research.

He performed his PhD under the guidance of Ulrike Gaul at the Rockefeller University in NYC, where he graduated in 2008, working on microRNAs and their role in the germline in Drosophila.
He went on as an EMBO and HFSP fellow postdoc in the lab of Giacomo Cavalli at the IGH in Montpellier, France, in September 2009, studying Polycomb epigenetic regulation in the germline.

In July 2014, he started his own lab as a junior group leader at the Max Planck Institute of Immunobiology and Epigenetics in Freiburg in the “Chromatin Regulation” department.
His lab has a focus on epigenetics and the very begin of life right after fertilization. Since January 2018, he is a EMBO young investigator.

In 2019, he was awarded with an ERC consolidator grant.


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