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Embryonic Development and Biology of Stem Cells


The interest of the Institute in developmental biology is rooted back at the time when IGB researchers pioneered mouse genetics using gene targeting techniques to study mammalian embryonic development.

The current research activity focuses at unravelling the genetic and the molecular basis of mouse development, with particular emphasis on the cardiovascular and neural systems, as well as on the early stages of mammalian embryogenesis, with the ultimate goal to improve our knowledge on key developmental processes and on the biology of stem cells. Specifically, by combining mouse genetics, ex vivo primary cultures, and genome-wide transcriptome/epigenome approaches, we study the genetic, epigenetic and metabolic control of pluripotent and adult stem cells.

The research activity concentrates on the molecular circuitries governing the decision between self-renewal and commitment to differentiation, both in physiology and disease. Thanks to a wide variety of genetic mouse models in which gene dosage of specific transcription and growth factors can be modulated both in space and time, we aim to gain insights into gene functions and regulatory pathways underlying muscular, cardiovascular and neural cell differentiation, from preimplantationembryonic development throughout adulthood. Based on this knowledge, IGB researchers are developing molecular and pharmacological tools to target progenitor/stem cells, paving the way for novel approaches to regenerative medicine and disease treatments.



Dario Acampora

Daniela Alfano

Antonio Baldini

Laura Casalino

Sara Cioffi

Dario De Cesare

Luca Di Giovannantonio

Annalisa Fico

Ombretta Guardiola

Gabriella Lania

Giovanna Liguori

Gabriella Minchiotti

Eduardo Jorge Patriarca

Antonio Simeone