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Neurobiology and Tissue differentiation


How cells differentiate and come together to form functional circuits is a primary question in neuroscience. IGB researchers study fundamental aspects of neurobiology finalized to understand the molecular mechanisms controlling neuronal development and the pathological processes that impair neural performance. To address these issues IGB researchers integrate a wide range of in vivo and in vitro approaches, including molecular and cellular biology, cellular reprogramming, pharmacology, histochemistry, behavioural analysis and neuronal imaging. As part of this research activity new genetic models in mice are currently generated to understand the role of genes and associated molecular pathways in controlling normal neuronal development and functions. This knowledge is used to identify disease mechanisms leading to pediatric developmental disorders such as Epilepsy, Schizophrenia and ageing-related neurodegenerative disorders such as Parkinson’s and Alzheimer diseases.

IGB scientists involved in this area actively share information and resources including identified disease-related pathways, cell and tissue samples, and background knowledge and expertise.

The interaction between researchers working on neuronal mechanisms shaping the earliest and latest phase of brain life has important implications to understand functioning of neuronal networks in health and disease.


Neurobiology and Brain Functioning


Gian Carlo Bellenchi

Elvira De Leonibus

Umberto di Porzio

Maria Giuseppina Miano

Carla Perrone Capano

Organogenesys and Tissue Differentiation


Antonella Prisco

Rosarita Tatè