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Research Interests

1. The regulation of the immune response: vaccine design, phage-based vaccines, Virus-like-particle vaccines, protein vaccines, Alzheimer's Disease immunotherapy,  induction of immune responses to self-antigens, correlates of vaccine efficacy, signaling in T cell development and activation (see Prisco et al. Immunity), T cell receptor repertoire in Coeliac disease, T cell receptor repertoire of antigen-specific T cell lines.

2. Modelling of biological phenomena: X chromosome inactivation (see News and Views, Nature Physics), pairing of homologous chromosomes, chromatin organization.


Short CV

1994,  Degree in Biology summa cum laude, University of Naples “Federico II”.

2002-present Research Scientist at IGB-ABT, CNR, Naples, Italy.
1998-2002 Post-doc in Victor Tybulewicz’s group, National Institute for Medical Research, MRC, London, UK.
1994-1997 AIRC fellow in J. Guardiola’s group, Istituto Internazionale di Genetica e Biofisica, CNR, Naples, Italy.
1996 Visitor in P. Kourilsky’s group, Istitut Pasteur, Paris, France.
1992-1994 Thesis student in M. Ciaramella’s group, Istituto di Biochimica delle Proteine ed Enzimologia, CNR, Naples, Italy.

22 scientific papers in international peer reviewed journals.

PCT/IB2009/050329 (pending). Multimeric proteins able to induce an antibody response against the beta-amyloid and use thereof. Inventors: Prisco A., De Berardinis P, De Falco D, Caivano A

Italian Patent  NA2008A000006. Inventors: Prisco A., De Berardinis P, De Falco D, Caivano A

Pbi International Prize for Cell Culture, 2004.


Selected Publications

How the interval between prime and boost injection affects the immune response in a computational model of the immune system, Castiglione F, Mantile F, De Berardinis P and Prisco A.  Computational and Mathematical Methods in Medicine (in press).


Memory immune response: a major challenge in vaccination. Prisco, A,  De Berardinis, P. BioMolecular Concepts. 2012 ISSN (Online) 1868-503X, ISSN (Print) 1868-5021, DOI: 10.1515/bmc-2012-0010, June 2012


Filamentous bacteriophage fd as an antigen delivery system in vaccination. Prisco A, De Berardinis P. Int J Mol Sci. 2012;13(4):5179-94. Epub 2012 Apr 24.


Conformation regulation of the X chromosome inactivation center: a model. Scialdone A, Cataudella I, Barbieri M, Prisco A, Nicodemi M. PLoS Comput Biol. 2011 Oct;7(10):e1002229. Epub 2011 Oct 27.


A multimeric immunogen for the induction of immune memory to beta-amyloid. Mantile F, Basile C, Cicatiello V, De Falco D, Caivano A, De Berardinis P, Prisco A. Immunol Cell Biol. 2011 Jul;89(5):604-9. doi: 10.1038/icb.2010.134. Epub 2010 Nov 23.


Increased Dickkopf-1 expression in transgenic mouse models of neurodegenerative disease. Rosi MC, Luccarini I, Grossi C, Fiorentini A, Spillantini MG, Prisco A, Scali C, Gianfriddo M, Caricasole A, Terstappen GC, Casamenti F. J Neurochem. 2010 Mar;112(6):1539-51. Epub 2009 Dec 29.


Thermodynamic pathways to genome spatial organization in the cell nucleus. Nicodemi M, Prisco A. Biophys J. 2009 Mar 18;96(6):2168-77.


The colocalization transition of homologous chromosomes at meiosis. Nicodemi M, Panning B, Prisco A. Phys Rev E Stat Nonlin Soft Matter Phys. 2008 Jun;77(6 Pt 1):061913. Epub 2008 Jun 17.


A thermodynamic switch for chromosome colocalization. Nicodemi M, Panning B, Prisco A. Genetics. 2008 May;179(1):717-21.


Self-assembly and DNA binding of the blocking factor in x chromosome inactivation. Nicodemi M, Prisco A. PLoS Comput Biol. 2007 Nov;3(11):e210. Epub 2007 Sep 18.


Immunogenicity and therapeutic efficacy of phage-displayed beta-amyloid epitopes. Esposito M, Luccarini I, Cicatiello V, De Falco D, Fiorentini A, Barba P, Casamenti F, Prisco A. Mol Immunol. 2008 Feb;45(4):1056-62. Epub 2007 Sep 11.


Symmetry-breaking model for X-chromosome inactivation. Nicodemi M, Prisco A. Phys Rev Lett. 2007 Mar 9;98(10):108104. Epub 2007 Mar 7.


Lineage-specific requirement for the PH domain of Vav1 in the activation of CD4+ but not CD8+ T cells.Prisco A, Vanes L, Ruf S, Trigueros C, Tybulewicz VL. Immunity. 2005 Sep;23(3):263-74.


Lack of patent liver autoimmunity after breakage of tolerance in a mouse model. Del Pozzo G, Mascolo D, Prisco A, Barba P, Anzisi A, Guardiola J. Int Immunol. 2003 Oct;15(10):1173-81.


Vav1: a key signal transducer downstream of the TCR. Tybulewicz VL, Ardouin L, Prisco A, Reynolds LF. Immunol Rev. 2003 Apr;192:42-52. Review.


Design of cassette vectors permitting cloning of all types of human TCR variable alpha and beta regions.Caivano A, D'Apice L, Tiberio C, Prisco A, Acuto O, Guardiola J, De Berardinis P. J Immunol Methods. 2001 Sep 1;255(1-2):125-34.


Unbalanced expression of HLA-A and -B antigens: a specific feature of cutaneous melanoma and other non-hemopoietic malignancies reverted by IFN-gamma. Gasparollo A, Coral S, Ciullo M, Prisco A, Cattarossi I, Sigalotti L, Altomonte M, Guardiola J, Maio M. Int J Cancer. 2001 Feb 15;91(4):500-7.


In vitro immunization with a recombinant antigen carrying the HIV-1 RT248-262 determinant inserted at different locations results in altered TCRVB region usage. Prisco A, Bonomi G, Moschella F, Ombra MN, De Berardinis P, Guardiola J. Hum Immunol. 1999 Sep;60(9):755-63.


Recognition of HIV-derived B and T cell epitopes displayed on filamentous phages. De Berardinis P, D'Apice L, Prisco A, Ombra MN, Barba P, Del Pozzo G, Petukhov S, Malik P, Perham RN, Guardiola J. Vaccine. 1999 Mar 17;17(11-12):1434-41.


The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways. Costello PS, Walters AE, Mee PJ, Turner M, Reynolds LF, Prisco A, Sarner N, Zamoyska R, Tybulewicz VL. Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3035-40.


Identical T-cell receptor beta chain rearrangements are present in T cells infiltrating the jejunal mucosa of untreated celiac patients. Prisco A, Troncone R, Mazzarella G, Gianfrani C, Auricchio S, Even J, Tiberio C, Guardiola J, De Berardinis P. Hum Immunol. 1997 Jun;55(1):22-33.


A gene encoding a putative membrane protein homologous to the major facilitator superfamily of transporters maps upstream of the beta-glycosidase gene in the archaeon Sulfolobus solfataricus. Prisco A, Moracci M, Rossi M, Ciaramella M. J Bacteriol. 1995 Mar;177(6):1614-9.

  • Piergiuseppe De Berardinis, IBP, CNR, Naples, Italy.
  • Mario Nicodemi, Warwick University, UK.
  • Fiorella Casamenti, Università di Firenze, Florence, Italy.
  • Barbara Panning, University of California San Francisco, USA.
  • Filippo Castiglione, IAC, CNR, Rome, Italy.


Keywords: Modulation of the immune response, modelling of biological phenomena

Antonella Prisco

CNR Researcher (Ricercatore)

+39 081 6132316-446

Staff Members:

Francesca Mantile
PhD Student (Dottorando)