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Research Interests
1. The regulation of the immune response: vaccine design, phage-based vaccines, Virus-like-particle vaccines, protein vaccines, Alzheimer's Disease immunotherapy, induction of immune responses to self-antigens, correlates of vaccine efficacy, signaling in T cell development and activation, T cell receptor repertoire in Coeliac disease, T cell receptor repertoire of antigen-specific T cell lines.

2. Modelling of biological phenomena: X chromosome inactivation, pairing of homologous chromosomes, chromatin organization.
Short CV

1994 Degree in Biology summa cum laude, University of Naples “Federico II”.


2002-present Researcher (Group leader) at IGB-ABT, CNR, Naples, Italy.
1998-2002 Post-doc in Victor Tybulewicz’s group, National Institute for Medical Research, MRC, London, UK.
1994-1997 AIRC fellow in J. Guardiola’s group, Istituto Internazionale di Genetica e Biofisica, CNR, Naples, Italy.
1996 Visitor in P. Kourilsky’s group, Istitut Pasteur, Paris, France.
1992-1994 Thesis student in M. Ciaramella’s group, Istituto di Biochimica delle Proteine ed Enzimologia, CNR, Naples, Italy.


36 scientific papers in international peer reviewed journals.
European patent (granted) EP 2238160 B1 Multimeric proteins able to induce an antibody response against the beta-amyloid and use thereof. Inventors: Prisco A., De Berardinis P, De Falco D, Caivano A
Italian Patent (granted) NA2008A000006. Inventors: Prisco A., De Berardinis P, De Falco D, Caivano A
Pbi International Prize for Cell Culture, 2004.
ORCID iD 0000-0001-8061-0068
Scopus Author ID: 6603401196
Selected Publications
Vaccination with (1-11)E2 in alum efficiently induces an antibody response to β-amyloid without affecting brain β-amyloid load and microglia activation in 3xTg mice.
Mantile F, Capasso A, Villacampa N, Donnini M, Liguori GL, Constantin G, De Berardinis P, Heneka MT, Prisco A.
Aging Clin Exp Res. 2019 Nov 22. doi: 10.1007/s40520-019-01414-0. [Epub ahead of print]

Inference of chromosome 3D structures from GAM data by a physics computational approach.
Fiorillo L, Bianco S, Chiariello AM, Barbieri M, Esposito A, Annunziatella C, Conte M, Corrado A, Prisco A, Pombo A, Nicodemi M.
Methods. 2019 Oct 8. pii: S1046-2023(18)30485-7. doi:

Arming Filamentous Bacteriophage, a Nature-Made Nanoparticle, for New Vaccine and Immunotherapeutic Strategies.
Sartorius R, D'Apice L, Prisco A, De Berardinis P.
Pharmaceutics. 2019 Sep 1;11(9). pii: E437. doi
: 10.3390/pharmaceutics11090437. Review.

Modeling Single-Molecule Conformations of the HoxD Region in Mouse Embryonic Stem and Cortical Neuronal Cells.
Bianco S, Annunziatella C, Andrey G, Chiariello AM, Esposito A, Fiorillo L, Prisco A, Conte M, Campanile R, Nicodemi M.
Cell Rep. 2019 Aug 6;28(6):1574-1583.e4. doi:

Identification of a Consolidation Phase in Immunological Memory.
Mantile F, Capasso A, De Berardinis P, Prisco A.
Front Immunol. 2019 Mar 19;10:508. doi: 10.3389/fimmu.2019.00508. eCollection 2019.

HIV Vaccination: A Roadmap among Advancements and Concerns.
Trovato M, D'Apice L, Prisco A, De Berardinis P.
Int J Mol Sci. 2018 Apr 19;19(4). pii: E1241. doi: 10.3390/ijms19041241. Review.

Structure of the human chromosome interaction network.
Sarnataro S, Chiariello AM, Esposito A, Prisco A, Nicodemi M.
PLoS One. 2017 Nov 15;12(11):e0188201. doi:
10.1371/journal.pone.0188201. eCollection 2017.

A Polymer Physics Investigation of the Architecture of the Murine Orthologue of the 7q11.23 Human Locus.
Chiariello AM, Esposito A, Annunziatella C, Bianco S, Fiorillo L, Prisco A, Nicodemi M.
Front Neurosci. 2017 Oct 10;11:559. doi: 10.3389/fnins.2017.00559.
eCollection 2017. Review.

E2 multimeric scaffold for vaccine formulation: immune response by intranasal delivery and transcriptome profile of E2-pulsed dendritic cells.
Trovato M, Maurano F, D'Apice L, Costa V, Sartorius R, Cuccaro F, McBurney SP, Krebs SJ, Prisco A, Ciccodicola A, Rossi M, Haigwood NL, De Berardinis P.
BMC Microbiol. 2016 Jul 16;16(1):152. doi: 10.1186/s12866-016-0772-x.

Alum and squalene-oil-in-water emulsion enhance the titer and avidity of anti-Aβ antibodies induced by multimeric protein antigen (1-11)E2, preserving the Igg1-skewed isotype distribution.
Mantile F, Trovato M, Santoni A, Barba P, Ottonello S, De Berardinis P, Prisco A.
PLoS One. 2014 Jul 1;9(7):e101474. doi: 10.1371/journal.pone.0101474. eCollection 2014.

Polymer models of chromatin organization.
Barbieri M, Scialdone A, Piccolo A, Chiariello AM, di Lanno C, Prisco A, Pombo A, Nicodemi M.
Front Genet. 2013 Jun 20;4:113. doi: 10.3389/fgene.2013.00113.
eCollection 2013.

Memory immune response: a major challenge in vaccination.
Prisco A, De Berardinis P.
Biomol Concepts. 2012 Oct;3(5):479-86. doi: 10.1515/bmc-2012-0010.

How the interval between prime and boost injection affects the immune response in a computational model of the immune system.
Castiglione F, Mantile F, De Berardinis P, Prisco A.
Comput Math Methods Med. 2012;2012:842329. Epub 2012 Sep 11.

Filamentous bacteriophage fd as an antigen delivery system in vaccination.
Prisco A, De Berardinis P.
Int J Mol Sci. 2012;13(4):5179-94. doi: 10.3390/ijms13045179. Epub 2012 Apr 24. Review.

Conformation regulation of the X chromosome inactivation center: a model.
Scialdone A, Cataudella I, Barbieri M, Prisco A, Nicodemi M.
PLoS Comput Biol. 2011 Oct;7(10):e1002229. doi:
10.1371/journal.pcbi.1002229. Epub 2011 Oct 27.

A multimeric immunogen for the induction of immune memory to beta-amyloid.
Mantile F, Basile C, Cicatiello V, De Falco D, Caivano A, De Berardinis P, Prisco A.
Immunol Cell Biol. 2011 Jul;89(5):604-9. doi: 10.1038/icb.2010.134. Epub 2010 Nov 23.

Increased Dickkopf-1 expression in transgenic mouse models of neurodegenerative disease.

Rosi MC, Luccarini I, Grossi C, Fiorentini A, Spillantini MG, Prisco A, Scali C, Gianfriddo M, Caricasole A, Terstappen GC, Casamenti F.

J Neurochem. 2010 Mar;112(6):1539-51. doi: 10.1111/j.1471-4159.2009.06566.x. Epub 2009 Dec 29.

Thermodynamic pathways to genome spatial organization in the cell nucleus.
Nicodemi M, Prisco A.

Biophys J. 2009 Mar 18;96(6):2168-77. doi: 10.1016/j.bpj.2008.12.3919.

The colocalization transition of homologous chromosomes at meiosis.
Nicodemi M, Panning B, Prisco A.
Phys Rev E Stat Nonlin Soft Matter Phys. 2008 Jun;77(6 Pt 1):061913. Epub 2008 Jun 17.

A thermodynamic switch for chromosome colocalization.
Nicodemi M, Panning B, Prisco A.
Genetics. 2008 May;179(1):717-21. doi: 10.1534/genetics.107.083154.

Self-assembly and DNA binding of the blocking factor in x chromosome inactivation.
Nicodemi M, Prisco A.
PLoS Comput Biol. 2007 Nov;3(11):e210. Epub 2007 Sep 18.

Immunogenicity and therapeutic efficacy of phage-displayed beta-amyloid epitopes.
Esposito M, Luccarini I, Cicatiello V, De Falco D, Fiorentini A, Barba P, Casamenti F, Prisco A.
Mol Immunol. 2008 Feb;45(4):1056-62. Epub 2007 Sep 11.

Symmetry-breaking model for X-chromosome inactivation.
Nicodemi M, Prisco A.
Phys Rev Lett. 2007 Mar 9;98(10):108104. Epub 2007 Mar 7.

Lineage-specific requirement for the PH domain of Vav1 in the activation of CD4+ but not CD8+ T cells.
Prisco A, Vanes L, Ruf S, Trigueros C, Tybulewicz VL.
Immunity. 2005 Sep;23(3):263-74.

Lack of patent liver autoimmunity after breakage of tolerance in a mouse model
G Del Pozzo, D Mascolo, A Prisco, P Barba, A Anzisi, J Guardiola
International immunology 15 (10), 1173-1181

Vav1: a key signal transducer downstream of the TCR.
Tybulewicz VL, Ardouin L, Prisco A, Reynolds LF.
Immunol Rev. 2003 Apr;192:42-52. Review.

Design of cassette vectors permitting cloning of all types of human TCR variable α and β regions
A Caivano, L D'Apice, C Tiberio, A Prisco, O Acuto, J Guardiola, ...
Journal of immunological methods 255 (1-2), 125-134

Unbalanced expression of HLA‐A and‐B antigens: A specific feature of cutaneous melanoma and other non‐hemopoietic malignancies reverted by IFN‐γ

A Gasparollo, S Coral, M Ciullo, A Prisco, I Cattarossi, L Sigalotti, ...
International journal of cancer 91 (4), 500-507

In vitro immunization with a recombinant antigen carrying the HIV-1 RT248–262 determinant inserted at different locations results in altered TCRVB region usage

A Prisco, G Bonomi, F Moschella, MN Ombra, P De Berardinis, ...
Human immunology 60 (9), 755-763

The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways.
Costello PS, Walters AE, Mee PJ, Turner M, Reynolds LF, Prisco A, Sarner N, Zamoyska R, Tybulewicz VL.
Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3035-40.

Recognition of HIV-derived B and T cell epitopes displayed on filamentous phages
P De Berardinis, L D'Apice, A Prisco, MN Ombra, P Barba, G Del Pozzo, ...
Vaccine 17 (11-12), 1434-1441

Identical T-cell receptor β chain rearrangements are present in T cells infiltrating the jejunal mucosa of untreated celiac patients
A Prisco, R Troncone, G Mazzarella, C Gianfrani, S Auricchio, J Even, ...
Human immunology 55 (1), 22-33

Polymorphism in the 5′ terminal region of the mRNA of HLA-DQA1 gene: Identification of four groups of transcripts and their association with polymorphism in the a 1 domain
A Maffei, G Del Pozzo, A Prisco, M Ciullo, PE Harris, EF Reed, ...
Human immunology 53 (2), 167-173

A gene encoding a putative membrane protein homologous to the major facilitator superfamily of transporters maps upstream of the beta-glycosidase gene in the archaeon …
A Prisco, M Moracci, M Rossi, M Ciaramella
Journal of bacteriology 177 (6), 1614-1619
Piergiuseppe De Berardinis, IBP, CNR, Naples, Italy.
Mario Nicodemi, University of Naples, Italy.
Filippo Castiglione, IAC, CNR, Rome, Italy.
Michael T Heneka, DZNE, Bonn, Germany
Gabriela Constantin, University of Verona, Italy.
Giovanna L. Liguori, IGB, CNR, Naples, Italy.

Keywords: Modulation of the immune response, modelling of biological phenomena

Antonella Prisco

CNR Researcher (Ricercatore)

+39 081 6132316-446

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