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You are here: Home / Staff
Research Interests
1980-1984:
•    Role of unequal crossing-over in the evolution of ribosomal genes.
•    Molecular and structural organization of the non-transcribed spacer (NTS) of ribosomal DNA of D. melanogaster.
•    Identification of transcription and processing signals of ribosomal genes of D. melanogaster.
•    Isolation and characterization of alternative messenger RNAs coding class I HLA genes.

1985-1991:
•    Isolation and identification of the structural organization of the human homeobox gene family (HOX Complex).
•    Expression analysis of several Hox genes in human embryos.
•    Expression analysis of the human Hox Complex in teratocarcinoma cells (N-tera2/D1) upon treatment with retinoic acid and the definition of temporal colinearity concept.
•    Molecular mechanism controlling the expression of the HOX Complex gene family in human teratocarcinoma cells (N-tera2/D1).

1992-1998:
•    Isolation of the murine homologs of the otd and ems homeobox containing genes and analysis of their expression during brain development.
•    Isolation and expression analysis both in invertebrate and vertebrate embryos of a new homeobox containing gene named Orthopedia (Otp).
•    Isolation and expression analysis in murine embryos of Dlx5 and Dlx6, two murine homologues of the Drosophila Distal-less gene.
•    Combined expression analysis of Otx, Emx, Dlx and Otp during development and definition of brain segmentary identities.
•    Temporal map during gastrulation of the retinoic acid effect on development and patterning of murine brain.
•    Role of Otx2 in the specification of rostral CNS (forebrain, midbrain and anterior hindbrain).
•    Role of Otx1 in corticogenesis, pituitary functions and sense organs development.
•    Identification of an Otx gene-dosage dependent mechanism required for patterning of developing brain and proper positioning of midbrain-hindbrain isthmic organizer.
•    In vivo dissection of Otx1 and Otx2 roles in brain development by using reciprocal knock-in mouse models: definition of extended functional equivalence between OTX1 and OTX2 proteins and the relevance of the Otx1 and Otx2 differential transcriptional control.

1999-2005:
•    Dissection of Otx2 roles during gastrulation: requirement of Otx2 in the visceral endoderm for specification of anterior identity, and in the early neuroectoderm for maintenance of the anterior identity (forebrain and midbrain).
•    Role of Otx1 and Otx2 in brain evolution: functional equivalence between the invertebrate Orthodenticle and the murine OTX1 and OTX2 gene products supports a conserved genetic program of brain development between insects and mammals.
•    Role of Orthopedia (Otp) in proliferation, migration and differentiation of the murine neuroendocrine hypothalamus.
•    Differential dosage-dependent roles of OTX2 in specifying regional identities and neuronal cell types during brain development.
•    Antagonistic role of Otx2 and Gbx2 in regionalization of midbrain and rostral hindbrain.
•    Evidence for an Otx2-dependent control of dorso-ventral patterning of the midbrain.
•    Role of Otx2 in the control of identity and fate of neuronal precursors in the ventral midbrain.

2006-2012
•    Otx2 cell-autonomous control of thalamic glutamatergic progenitors.
•    Expression complexity of the Otx2 locus: transcriptional, post-transcriptional and translational regulation of Otx2 mRNA isoforms control specification and maintenance of forebrain and midbrain regional identities.
•    Role of Otx2 in dopaminergic neurogenesis: dose-dependent, anterior -posterior and dorsal-ventral integrated control by Otx2 regulates proliferation, number and neurotransmitter phenotype of dopaminergic progenitors.
•    Role of Otx2 in adult dopaminergic neurons: Otx2 specify post-mitotic neuron subtype identity in ventral tegmental area (VTA) and antagonizes dopaminergic vulnerability to the Parkinsonian neurotoxin MPTP.
•    Role of Orthopedia in neurogenesis of diencephalic dopaminergic neurons.
•    Role of Orthopedia in migration of diencephalic progenitors fated to populate the telencephalic amygdala.
•    Role of Otx1 and Otx2 in initiation and progression of desmoplastic Sonic Hedgehog-dependent medulloblastomas.
•    Identification of Otx1 as a selective diagnostic marker of aggressive Lymphomas.

2013 up today
•    Role of Otx2 in neurogenesis and regional identity of dorsal midbrain.
•    Role of Otx2 in Embryonic Stem Cells (ESCs): Otx2 is an intrinsic determinant required to maintain the ESC metastable state by antagonizing ground state pluripotency and promoting commitment to differentiation.
•    Role of Otx2 in Epiblast Stem Cells (EpiSCs): Otx2 stabilizes the primed EpiSC state by suppressing mesendoderm into neural fate switch in cooperation with BMP4 and Fgf2.
•    Role of Otx2 in ESC-based induction of telencephalic neurons: Otx2- mediated requirement for specification of dorsal cortical neurons.
•    Role of Otx2 in the transition to primed pluripotency: Otx2 controls transition into primed pluripotency by recruiting Oct4 at new enhancers associated to ESC-derived epiblast-like cells (EpiLCs) differentiation.
•    Design of a diagnostic kit to predict late onset of sporadic Parkinson's Disease.
•    Role of Otx2 in the direct control of the Nanog pluripotency core factor: through binding to the Nanog promoter, Otx2 controls the integrity of specific ESC sub-type compartments and in vivo the differentiation of the the epiblast lineage.
•    Role of Otx2 in metastability: through mutual antagonism, Otx2 and Nanog specify the heterogeneous identity of metastable ESCs and individually predispose ESCs for optimal response to naïve or formative inducing factors.

Short CV

Education
1988: Ph.D in Cellular and Molecular Genetics, University of Naples.
1981: Graduated in Biological Sciences, University of Naples.

Honours and Prizes

2013    Prize "Science Award Stadt Freising" for German-Italy interactive studies on Dopaminergic neurons.

2009: Prize “ Tabor ” for the studies on neurodegeneration awarded by Archidiocesan Curia and Municipality of Amalfi.

2003: Special Prize "Il Gladiatore d’Oro" awarded by Province of Benevento.

2000: The Liliane BETTENCOURT Life Sciences Award.

1998: Italian Society of Biophysic and Molecular Biology (SIBBM) Prize in memory

of "Dr. M. Chiara D'Onofrio".

1988: ARFACID prize in memory of "Prof. Eduardo Scarano".

1986: Italian Association of Medical Genetics (AIGM) Prize.

Appointments

2018-              Acting Director of the Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”, CNR, Naples
2014- 2018    Director of the Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”, CNR, Naples
2014-2016    CNR Representative of the "Comitato di Indirizzo Strategico" related to "Accordo Quadro CNR/Regione Molise"
2013-2014    Acting Director of the Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”, CNR, Naples
2004-2012        Professor of the Scuola Superiore Europea di Medicina Molecolare (SEMM)
2005-2012      Group leader at the CEINGE Biotecnologie Avanzate, Naples
2001        CNR "Dirigente di Ricerca" at the Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”, CNR, Naples.
2000-2006      Group leader at the MRC Centre for Developmental Neurobiology (London).
2000-2005      Full Professor of Developmental Genetics at the King's College London.
1997-2001      CNR "Primo Ricercatore" at the Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”, CNR, Naples.
1992-2004     Group leader at the Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”, CNR, Naples.
1988-1997     CNR "Ricercatore" at the Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”, CNR, Naples.



Editorial activities
•    Member of the editorial board of, and International Journal of Developmental Biology and Development
•    Previously member of the editorial board of Human Reproduction, Molecular Reproduction and Development, and Genes and Function.
•    Reviewer for Nature Neuroscience, Nature Genetics, Developmental Cell, Genes and Development, Neuron, •    Developmental Biology, Mechanisms of Development, The Journal of Neuroscience, Stem Cell Reports, PLoS Genetics.


Professional body membership
•    Scientific Advisory Board of the Max Planck Institute for Biophysical Chemistry (Gottingen)
•    European Molecular Biology Organization (EMBO)
•    European Society of Human Reproduction and Embryology (ESHRE)
•    Italian Society of Biophysics and Molecular Biology (SIBBM)
•    Fellowships committee of Human Frontier Science Program Organization (HFSP)
•    Armenise-Harvard Italian Scholarship Advisory Committee (ISAC)
•    Member of the Scientific Committee of the Foundation Cariplo


Selected Research Projects since 1993
•    PRIN Project (2017-2020): Regolazione e funzione dei fattori trascrizionali modificatori epigenetici che intervengono nel differenziamento delle cellule staminali embrionali e epiblasti.
•    PON MISE Project (2015-2018) (scientific coordinator): Realizzazione di strumenti diagnostici per l'analisi precoce del morbo di Parkinson attraverso l'identificazione di profili genetici di rischio
•    PON03 Project (2013-2018): Preclinical development of new therapies and innovative strategies for the production of molecules with pharmacological activity.
•    AIRC Project (2013-2016): The Otx2 regulatory network controlling pluripotent stem cell states and their susceptibility to tumorigenesis
•    POR MOVIE Project (2012-2015) (research unit): Modelli in vivo models of human pathologies.
•    FP7 EU Project (2009-2011): Molecular coding and subset specification of dopamine neurons generating the meso-limbic and nigro-stratal system.
•    AIRC Project (2008-2012): Otx genes in medulloblastoma: a genetic study to unravel their role in tumorigenesis of cerebellar progenitors.
•    FP6 EU Project (2007-2011): European Transcriptome, Regulome & Cellular Commitment.
•    Fondazione Cassa di Risparmio di Roma Project (2007-2010): Ruolo dei geni Otx nel differenziamento e nella proliferazione dei progenitori neurali e delle cellule staminali.
•    PRIN Project (2008-2010): Ruolo del gene Otx2 nel differenziamento telencefalico mediante l’uso di modelli murini e cellule ES geneticamente modificati.
•    AIRC Project (2005-2007): Otx2 in proliferation and differentiation of neural progenitors: implications for a tumor-suppressor activity.
•    FIRB Genotopo Project (2003-2005).
•    Wellcome Trust Programme Grant (2001-2005): The role of Otx2 in the evolution of complexity in the vertebrate brain.
•    FP5 EU Project (2001-2004): Comparative approach to the analysis of molecular pathways underlying cell communication mechanisms in forebrain patterning
•    Medical Research Council (MRC) Programme Grant (2000-2004): Functional Properties of Otx1 and Otx2 in Brain and Sense Organ Development.
•    AIRC (1998-2001): Role of Otx and Otp genes in specification of the brain and development of neuroendocrine hypothalamus.
•    Telethon Project (1997-2000): Role of Otx1 and Otx2 genes in brain morphogenesis and their involvement in generating epilepsy and otocephaly".
•    Progetto Finalizzato Biotecnolgie (1997-1999): Ruoli e proprietà dei geni Otx nella definizione e evoluzione del cervello e di Otp (Orthopedia) nel differenziamento e funzionalità dell'ipotalamo neuroendocrino.
•    AIRC Project (1994-1996): Studio dell'effetto dei fattori di crescita nel differenziamento e nella proliferazione cellulare durante l'embriogenesi e l'emopoiesi.
•    AIRC (1993-1994): Ruolo dei geni umani contenenti l'homeobox nel differenziamento e nella trasformazione cellulare.
•    Telethon Project (1993-1995): Production of null mutations in the Otx1 and Otx2 homeobox-containing genes: involvement in brain morphogenesis.
•    Progetto AIRC (1991-1994): Ruolo dei geni umani contenenti l'homeobox nel differenziamento e nella trasformazione cellulare.

Relevant teaching activity
2004-2011:         Professor of the Scuola Superiore Europea di Medicina Molecolare (SEMM) at CEINGE Biotecnologie Avanzate site of Naples
2000-2005:     Professor of Developmental Genetics at the King's College London.

International Congresses and Seminars
He has participated as speaker in more than 70 International Congresses and also held 200 seminars.


Referral Activities of Research Projects
He was referee for National and International Projects in different Organizations as the Medical Research Council (MRC), the Wellcome Trust, the French National Research Agency (ANR), the Cariplo Foundation, the Banco San Paolo Foundation, the Max Planck and occasionally the ERC.

Selected Publications
Hirsch (H) index and Citations
  • H Index Google Scholar:  73           Citazioni: 16632
  • H-index ISI Web:              67           Citazioni: 12894
  • H-index Scopus:               65           Citazioni: 12470
Selected Publications
A. Simeone has co-authored 165 articles published on peer review journals; below is reported a list of the most significant research articles and reviews

  •  J. Zhang, M. Zhang, D. Acampora, D. Yuan, A. Simeone, I. Chambers. Otx2 restricts entry to the mouse germline. Nature in press
  •   D. Acampora, L. G. Di Giovannantonio, A. Garofalo, V. Nigro, D. Omodei, A. Lombardi, J. Zhang, I. Chambers & A. Simeone.  Functional antagonism between OTX2 and NANOG specifies a spectrum of heterogeneous identities in embryonic stem cells. Stem Cell Reports. 9, 1642-1659 (2017)
  •  H. H. Lee, C. Bernard, Z. Ye, D. Acampora, A. Simeone, A. Prochiantz, A. A. Di Nardo & T. K. Hensch.  Genetic Otx2 mis-localization delays critical period plasticity across brain regions. Mol. Psychiatry 22, 680-688 (2017)
  • D. Acampora, D. Omodei, G. Petrosino, A. Garofalo, M. Savarese, V. Nigro, L. G. Di Giovannantonio, V. Mercadante & A. Simeone. Loss of Otx2 binding site to the Nanog promoter affects integrity of embryonic stem cell sub-type compartments and differentiation of inner cell mass-derived epiblast. Cell Reports 15, 2651-64 (2016)
  • L. Panman, M. Papathanou, A. Laguna, T. Oosterveen, N. Volakakis, D. Acampora, I. Kurtsdotter, T. Yoshitake, J. Kehr, E. Joodmardi, J. Muhr, A. Simeone, J. Ericson & T. Perlmann. Sox6 and Otx2 control the specification of substantia nigra and ventral tegmental area dopamine neurons. Cell Reports 8,1018-1025 (2014)
  • C. Buecker, R. Srinivasan, Z. Wu, E. Calo, D. Acampora, T. Faial, A. Simeone, M. Tan, T. Swigut & J. Wysocka. Reorganization of enhancer patterns in transition from naïve to primed pluripotency. Cell Stem Cell. 14, 838-853 (2014)
  • L.G. Di Giovannantonio, M. Di Salvio, D. Omodei, N. Prakash, W. Wurst, A. Pierani, D. Acampora & A. Simeone. Otx2 cell-autonomously determines dorsal mesencephalon versus cerebellum fate independently of isthmic organizing activity. Development. 14, 1377-1388 (2014)
  • D. Acampora, L. G. Di Giovannantonio & A. Simeone. Otx2 is an intrinsic determinant of the Embryonic Stem Cell state and is required for transition to a stable Epiblast Stem Cell condition. Development. 140, 43-55 (2013)
  • M. Di Salvio, L. G. Di Giovannantonio, D. Acampora, R. Prosperi, D. Omodei, N. Prakash, W. Wurst & A. Simeone.  Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP.  Nature Neurosci. 13, 1481-1488 (2010)
  • F. García-Moreno, M. Pedraza, L. G. Di Giovannantonio, M. Di Salvio, L. López-Mascaraque, A. Simeone & J.A. De Carlos. A neuronal migratory pathway crossing from diencephalon to telencephalon populates amygdala nuclei. Nature Neurosci.13, 680-689 (2010)
  • N. Prakash, E. Puelles, K. Freude, D. Trümbach, D. Omodei, M. Di Salvio, L. Sussel, J. Ericson, M. Sander, A. Simeone* & W. Wurst. Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain. Development 136, 2545-2555 (2009)
  • P. P. Tripathi, L. G. Di Giovannantonio, A. Viegi, W. Wurst, A. Simeone* & Y. Bozzi.  Serotonin Hyperinnervation Abolishes Seizure Susceptibility in Otx2 Conditional Mutant Mice. The Journal of Neuroscience 28, 9271-9276 (2008)
  • D. Omodei, D. Acampora, P. Mancuso, N. Prakash, L. G. Di Giovannantonio, W. Wurst & A. Simeone.  Anterior-posterior graded response to Otx2 controls proliferation and differentiation of dopaminergic progenitors in the ventral mesencephalon. Development 135, 3459-3470 (2008)
  •  S. Ryu, J. Mahler, D. Acampora, J. Holzschuh, S. Erhardt, D. Omodei, A. Simeone* & W. Driever. Orthopedia homeodomain protein is essential for diencephalic dopaminergic neuron development. Current Biology 17, 873-80 (2007)
  • N. Prakash, C. Brodski, T. Naserke, E. Puelles, R. Gogoi, A. Hall, M. Panhuysen, D. Echevarria, L. Sussel, D. M. Weisenhorn, S. Martinez, E. Arenas, A. Simeone* & W. Wurst. A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo. Development. 133, 89-98 (2006)
  • E. Puelles, D. Acampora, R. Gogoi, F. Tuorto, A. Papalia, F. Guillemot, S. L. Ang & A. Simeone.  Otx2 controls identity and fate of glutamatergic progenitors of the thalamus by repressing GABAergic differentiation.  The Journal of Neuroscience 26, 5955-64 (2006)
  • E. Puelles, A. Annino, F. Tuorto, A. Usiello, D. Acampora, T. Czerny, S. L. Ang, W. Wurst & A. Simeone. Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain.  Development 131, 2037-2048 (2004)
  • E. Puelles, D. Acampora, E. Lacroix, M. Signore, A. Annino, F. Tuorto, S. Filosa, G. Corte, W. Wurst, S. L. Ang & A. Simeone. Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain.  Nature Neuroscience 6, 453-460 (2003)
  • J. P. Martinez-Barbera, M. Signore, P. Pilo Boyl, E. Puelles, D. Acampora, R. Gogoi, F. Schubert, A. Lumsden & A. Simeone. Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2. Development 128, 4789-4800 (2001)
  • D. Acampora, P. Pilo Boyl, M. Signore, J. P. Martinez-Barbera, C. Ilengo, E. Puelles, A. Annino, H. Reichert, G. Corte & A. Simeone. OTD/OTX2 functional equivalence depends on 5’ and 3’ UTR-mediated control of Otx2 mRNA for nucleo-cytoplasmic export and epiblast-restricted translation. Development 128, 4801-4813 (2001)
  • D. Acampora, V. Avantaggiato, F. Tuorto, P. Barone, M. Perera, G. Corte, & A. Simeone. Differential transcriptional control as the major molecular event in generating Otx1-/- and Otx2-/- divergent phenotypes. Development 126, 1417-1426 (1999)
  • M. Hidalgo-Sanchez, A. Simeone & R. M. Alvarado-Mallart. Fgf8 and Gbx2 induction concomitant with Otx2 repression is correlated with midbrain-hindbrain fate of caudal prosencephalon. Development 126, 3191-3203 (1999)
  • D. Acampora, M. P. Postiglione, V. Avantaggiato, M. Di Bonito, F. Vaccarino, J. Michaud & A. Simeone. Progressive impairment of developing neuroendocrine cell lineages in the hypothalamus of mice lacking the Orthopedia gene.  Genes & Development 13, 2787-800 (1999)
  • D. Acampora, V. Avantaggiato, F. Tuorto, P. Barone, H. Reichert, R. Finkelstein & A. Simeone. Murine Otx1 and Drosophila otd genes share conserved genetic functions required in invertebrate and vertebrate brain development. Development 125, 1691-1702  (1998)
  • D. Acampora, V. Avantaggiato, F. Tuorto, P. Briata, G. Corte & A. Simeone. Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation. Development 125, 5091-5104 (1998)
  • D. Acampora, V. Avantaggiato, F. Tuorto & A. Simeone. Genetic control of brain morphogenesis through Otx gene dosage requirement. Development 127, 3639-3650 (1997)
  • S. Brunelli, A. Faiella, V. Capra, V. Nigro, A. Simeone, A. Cama & E. Boncinelli. Germline mutations in the homeobox gene EMX2 in patients with severe schizencephaly. Nature Genetics 12, 94-96 (1996)
  • D. Acampora, S. Mazan, V. Avantaggiato, P. Barone, F. Tuorto, Y. Lallemand, P. Brûlet & A. Simeone. Epilepsy and brain abnormalities in mice lacking Otx1 gene. Nature Genetics 14, 218-222 (1996)
  • V. Avantaggiato, P. P. Pandolfi, M. Ruthardt, N. Hawe, D. Acampora, P. G. Pelicci & A. Simeone. Developmental analysis of murine Promyelocyte Leukemia Zinc Finger (PLZF) gene expression: implications for the neuromeric model of the forebrain organization. The Journal of Neuroscience 15, 4927-4942 (1995)
  • D. Acampora, S. Mazan, Y. Lallemand, V. Avantaggiato, M. Maury, A. Simeone & P. Brulet. Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation. Development 121, 3279-3290 (1995)
  • A. Simeone, D. Acampora, M. Pannese, M. D'Esposito, A. Stornaiuolo, M. Gulisano, A. Mallamaci, K. Kastury, T. Druck, K. Huebner & E. Boncinelli. Cloning and characterization of two new members of the vertebrate Dlx gene family. Proc. Nat. Acad. Sci. USA 91, 2250-2254 (1994)
  • A. Simeone, M. R. D'Apice, V. Nigro, J. Casanova, F. Graziani, D. Acampora & V. Avantaggiato.  Orthopedia, a novel homeobox-containing gene expressed in the developing CNS of both mouse and Drosophila. Neuron 13, 83-101 (1994)
  • A. Simeone, D. Acampora, A. Mallamaci, A. Stornaiuolo, M. R. D'Apice, V. Nigro & E. Boncinelli. A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid  class and demarcates anterior neuroectoderm in the gastrulating mouse embryo. EMBO J. 12, 2735-2747 (1993)
  • A. Simeone, M. Gulisano, D. Acampora, A. Stornaiuolo, M. Rambaldi & E. Boncinelli. Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex. EMBO J. 11, 2541-2550 (1992)
  • A. Simeone, D. Acampora, M. Gulisano, A. Stornaiuolo & E. Boncinelli. Nested expression domains of four homeobox genes in developing rostral brain. Nature 358, 687-690 (1992)
  • A. Simeone, D. Acampora, L. Arcioni, P. W. Andrews, E. Boncinelli & F. Mavilio. Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells. Nature 346, 763-766 (1990)
  • A. Simeone, F. Mavilio, D. Acampora, A. Giampaolo, A. Faiella, V. Zappavigna, M. D'Esposito, M. Pannese, G. Russo, E. Boncinelli & C. Peschle. Two human homeobox genes, c1 and c8: structure analysis and expression embryonic development. Proc. Natl. Acad. Sci. 84, 4914-4918 (1987)
  • A. Simeone, F. Mavilio, L. Bottero, A. Giampaolo, G. Russo, A. Faiella, E. Boncinelli & C. Peschle. A human homeo box gene specifically expressed in spinal cord during embryonic development. Nature 320, 763-765 (1986)
  • F. Mavilio, A. Simeone, A. Giampaolo, A. Faiella, V. Zappavigna, D. Acampora, G. Poiana, G. Russo, C. Peschle & E. Boncinelli. Differential and stage-related expression in embryonic tissue of a new human homeobox gene. Nature 324, 664-668 (1986)
  • B. Majello, G. La Mantia, A. Simeone, E. Boncinelli & L. Lania. Activation of major histocompatibility complex class I mRNA containing an Alu-like repeat in polyoma virus-transformed rat cells. Nature 314, 457-459 (1985)

*Co-corresponding author.

Selected Reviews

  • A. Simeone, M. Di Salvio, L. G. Di Giovannantonio, D. Acampora, D. Omodei & C. Tomasetti. The Role of Otx2 in Adult Mesencephalic-Diencephalic Dopaminergic Neurons. Mol. Neurobiol. 43, 107-113 (2011)
  • A. Simeone. The genetic control of dopaminergic differentiation. Trends Neurosci. 28, 62-65 (2005)
  • A. Simeone. Towards the comprehension of genetic mechanisms controlling brain morphogenesis. Trends Neurosci. 25, 119-121 (2002)
  • A. Simeone, E. Puelles & D. Acampora. The Otx family. Curr Opin Genet Dev 12, 409-415 (2002)
  • H. Reichert & A. Simeone. Developmental genetic evidence for a monophyletic origin of the bilaterian brain.  Philos Trans R Soc Lond B Biol Sci 356,1 533-544 (2001)
  • A. Simeone. Positioning the isthmic organizer where Otx2 and Gbx2 meet. Trends in Genetics 16, 237-240 (2000)
  • R. Cantos, L. K. Cole, D. Acampora, A. Simeone & D. K. Wu. Patterning of the mammalian cochlea. Proc. Natl. Acad. Sci. 97, 11707-11713 (2000)
  • D. Acampora & A. Simeone. Understanding the roles of Otx1 and Otx2 in the control of brain morphogenesis.  Trends in Neuroscience 22, 116-122 (1999)
  • H. Reichert & A. Simeone. Conserved usage of gap and homeotic genes in patterning the CNS. Curr. Opin. Neurobiol. 9, 589-595 (1999)
  • A. Simeone. Otx1 and Otx2 in the development and evolution of the mammalian brain.  EMBO J. 17, 6790-6798 (1998)

 

Collaborations
Main collaborations in the last 10 years

Prof. Wolfgang Wurst
Helmholtz Zentrum München
Institute of Developmental Genetics
Ingolstaedter Landstr. 1
85764 Neuherberg
Germany

Prof. M.P. Smidt
Department of Neuroscience and Pharmacology
UMC-Utrecht
Universiteitsweg 100
3584CG, Utrecht
The Netherlands

Prof. Alain Prochiantz
CNRS UMR 8542 Chaire des Processus Morphogénétiques
Collège de France
11, Place Marcelin Berthelot
75231 Paris Cedex 05

Prof. Dr. Wolfgang Driever
Developmental Biology Unit
Department of Biology I
University of Freiburg
Hauptstrasse 1
D-79104 Freiburg
Germany

Prof. Ian Chambers
MRC Centre for Regenerative Medicine
The University of Edinburgh
Edinburgh BioQuarter
5 Little France Drive
Edinburgh
EH16 4UU

Prof. Joanna Wysocka
Department of Chemical and Systems Biology,
Stanford University School of Medicine,
Stanford, CA 94305
USA

Prof. Thomas Perlmann
Department of Cell and Molecular Biology
Karolinska Institutet
17177 Stockholm
Sweden
 

Keywords: Developmental Neurobiology, Otx, Otp


Antonio Simeone

CNR Research Director - IGB Director

+39 081 6132 242/401
antonio.simeone@igb.cnr.it
Homepage

Staff Members:

Dario Acampora
CNR Researcher (Primo Ricercatore)

Luca Di Giovannantonio
CNR Technologist (Tecnologo)

Daniela Omodei
PostDoc