BEGIN:VCALENDAR
VERSION:2.0
METHOD:PUBLISH
CALSCALE:GREGORIAN
PRODID:-//WordPress - MECv7.30.0//EN
X-ORIGINAL-URL:https://www.igb.cnr.it/
X-WR-CALNAME:
X-WR-CALDESC:
X-WR-TIMEZONE:Europe/Rome
BEGIN:VTIMEZONE
TZID:Europe/Rome
X-LIC-LOCATION:Europe/Rome
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20260329T030000
RRULE:FREQ=YEARLY;BYMONTH=03;BYDAY=-1SU
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20261025T020000
RRULE:FREQ=YEARLY;BYMONTH=10;BYDAY=4SU
END:STANDARD
END:VTIMEZONE
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-PUBLISHED-TTL:PT1H
X-MS-OLK-FORCEINSPECTOROPEN:TRUE
BEGIN:VEVENT
CLASS:PUBLIC
UID:MEC-73091f523aa6c6f44674cdb664bf39b3@igb.cnr.it
DTSTART;TZID=Europe/Rome:20250519T120000
DTEND;TZID=Europe/Rome:20250519T133000
DTSTAMP:20250409T104737Z
CREATED:20250409
LAST-MODIFIED:20250506
PRIORITY:5
SEQUENCE:2
TRANSP:OPAQUE
SUMMARY:Dott. Isidro Cortes-Ciriano – “Computational cancer genome analysis at a national scale: insights into cancer onset and evolution”
DESCRIPTION:Dott. Isidro Cortes-Ciriano\nEuropean Bioinformatics Institute -European Molecular Biology\nLaboratory (EMBL-EBI) Hinxton, Cambridge, UK\nMy laboratory focuses on the development of computational methods to study the mechanisms underpinning cancer genome complexityand evolution, and to harness novel technologies applicable inclinical settings to improve early cancer detection and treatment selection. In this talk, I will first discuss our work on the characterization of the mechanisms underpinning theevolutionary trajectories of the diverse spectrum of complex genomic rearrangementsobserved across diverse cancer types, such as chromothripsis. Specifically, I willpresent the discovery of a novel rearrangement mechanism, loss-translocation-amplification (LTA) chromothripsis, which mediates rapid malignant transformation and punctuated evolution in about half of paediatric and adult high-grade osteosarcomas.I will also present novelalgorithms for the detection of somatic structural variants using long-read sequencing data, and their application for the reconstruction of complex rearrangementsin clinical samplesat a national scale. Finally, I will showcase the potential of nanopore sequencing for liquid biopsy analysis in the context of paediatric cancer,an approach that we have developed and validated clinically under the auspices of the Stratified Medicine Paediatrics Programme in the UK. Specifically, I will show that nanopore sequencing of small volumes of plasma cell-free DNA permits the detection ofcancer-specific mutations and epigenomic aberrationsin circulating tumour DNA for accurate diagnosis of cancer, monitoring of disease burden, and early detection of relapse in paediatric cancer patients.\nIsidro Cortés-Ciriano joined EMBL-EBI as Research Group Leader in June 2019 after completing postdoctoral training at Harvard MedicalSchool, under the supervision of Prof. Peter Park. Isidro completed his PhD at the Pasteur Institute in 2015, after obtaining MSc degrees in biology and biochemistry (major in bioinformatics) fromthe University of Navarra\nIGB Seminar 19 Maggio 2025 - Cortes-Ciriano\n
URL:https://www.igb.cnr.it/index.php/events/dott-isidro-cortes-ciriano-computational-cancer-genome-analysis-at-a-national-scale-insights-into-cancer-onset-and-evolution/
ORGANIZER;CN=Fernando Gianfrancesco:MAILTO:fernando.gianfrancesco@igb.cnr.it
CATEGORIES:External Seminars
LOCATION:Via Pietro Castellino 111 - Napoli
ATTACH;FMTTYPE=image/jpeg:https://www.igb.cnr.it/wp-content/uploads/2025/04/igb_facade-272x182-1.jpg
END:VEVENT
END:VCALENDAR