{"id":18237,"date":"2025-03-27T10:42:20","date_gmt":"2025-03-27T09:42:20","guid":{"rendered":"https:\/\/www.igb.cnr.it\/?page_id=18237"},"modified":"2025-03-31T17:44:27","modified_gmt":"2025-03-31T15:44:27","slug":"federica-scotto-di-carlo","status":"publish","type":"page","link":"https:\/\/www.igb.cnr.it\/index.php\/federica-scotto-di-carlo\/","title":{"rendered":"Federica Scotto di Carlo"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"18237\" class=\"elementor elementor-18237\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-29d7e4e5 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"29d7e4e5\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-39c1933e\" data-id=\"39c1933e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-dc35ed1 elementor-widget elementor-widget-bdt-member\" data-id=\"dc35ed1\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;none&quot;}\" data-widget_type=\"bdt-member.bdt-phaedra\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"bdt-member skin-phaedra bdt-transition-toggle\">\n\t\t\t\n\t\t\t\t<div class=\"bdt-member-photo-wrapper\">\n\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"bdt-member-photo\">\n\t\t\t\t\t\t<div class=\"\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2025\/03\/IMG_3194-scaled.jpeg\" title=\"IMG_3194\" alt=\"IMG_3194\" loading=\"lazy\" \/>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t<\/div>\n\n\t\t\t\n\t\t\t<div class=\"bdt-member-overlay bdt-overlay-default bdt-position-cover bdt-transition-fade bdt-position-z-index\">\n\t\t\t\t<div class=\"bdt-member-desc bdt-position-center bdt-text-center\">\n\t\t\t\t\t<div class=\"bdt-member-content bdt-transition-slide-top-small\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-31f45cb9\" data-id=\"31f45cb9\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5301ed90 elementor-widget elementor-widget-heading\" data-id=\"5301ed90\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Federica Scotto di Carlo<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-15ae93db elementor-widget elementor-widget-text-editor\" data-id=\"15ae93db\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3><strong><span style=\"color: #006293;\">Researcher<\/span><\/strong><\/h3><p><strong><img decoding=\"async\" class=\"alignnone wp-image-2318\" src=\"http:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona.png\" sizes=\"(max-width: 17px) 100vw, 17px\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona.png 512w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-300x300.png 300w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-150x150.png 150w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-270x250.png 270w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-510x510.png 510w\" alt=\"\" width=\"17\" height=\"17\" \/> +390816132221 \u00a0\u00a0 <img decoding=\"async\" class=\"alignnone wp-image-2317\" src=\"http:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png\" sizes=\"(max-width: 19px) 100vw, 19px\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png 512w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-300x300.png 300w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-150x150.png 150w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-270x250.png 270w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-510x510.png 510w\" alt=\"\" width=\"19\" height=\"19\" \/> federica.scotto@igb.cnr.it\u00a0<\/strong><\/p><div><strong>Genetics, Genomics and Epigenetics of Diseases\/Molecular Oncology<\/strong><\/div><div><p><strong>Keywords: <\/strong>Genome instability; osteosarcoma; cell cycle; mitosis; cancer metabolism<\/p><p><strong>\u00a0<\/strong><\/p><\/div><div>\u00a0<\/div><div>\u00a0<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2c340f0 e-grid-align-left elementor-shape-rounded elementor-grid-0 elementor-widget elementor-widget-social-icons\" data-id=\"2c340f0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"social-icons.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-social-icons-wrapper elementor-grid\" role=\"list\">\n\t\t\t\t\t\t\t<span class=\"elementor-grid-item\" 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data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-61dcc4d2\" data-id=\"61dcc4d2\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-23a91b19 elementor-widget elementor-widget-eael-adv-tabs\" data-id=\"23a91b19\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"eael-adv-tabs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t        <div data-scroll-on-click=\"no\" data-scroll-speed=\"300\" id=\"eael-advance-tabs-23a91b19\" class=\"eael-advance-tabs eael-tabs-horizontal eael-tab-auto-active \" data-tabid=\"23a91b19\">\n            <div class=\"eael-tabs-nav\">\n                <ul class=\"\" role=\"tablist\">\n                                            <li id=\"research-interest\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"research-interest-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >Research Interest<\/span>                                                    <\/li>\n                                            <li id=\"selected-publications\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"selected-publications-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >Selected Publications<\/span>                                                    <\/li>\n                                            <li id=\"professional-experience\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"false\" data-tab=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"professional-experience-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >Professional Experience<\/span>                                                    <\/li>\n                                    <\/ul>\n            <\/div>\n            \n            <div class=\"eael-tabs-content\">\n\t\t        \n                    <div id=\"research-interest-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"research-interest-tab\">\n\t\t\t\t        <p>Federica is a researcher in Fernando Gianfrancesco\u2019s <em>Bone Diseases and Tumors<\/em> laboratory. Her main scientific interest is understanding the molecular basis of genome instability in cancer. Combining her expertise in cancer genetics with her recent transition into cancer cell biology, she investigates the mechanisms underlying genome integrity maintenance and metabolic regulation.<\/p><p>Using imaging and next-generation sequencing technologies, her research explores the mechanisms governing cell cycle progression, mitotic division, DNA damage response, and metabolic reprogramming in both physiological and cancerous contexts. To achieve this, she employs mouse models and CRISPR\/Cas9-based cell systems.<\/p><p><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone size-large wp-image-18271\" src=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2025\/03\/1s-1024x686.png\" alt=\"\" width=\"1024\" height=\"686\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2025\/03\/1s-1024x686.png 1024w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2025\/03\/1s-300x201.png 300w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2025\/03\/1s-768x514.png 768w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2025\/03\/1s.png 1286w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/p><p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-18270 alignleft\" src=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2025\/03\/2s.png\" alt=\"\" width=\"490\" height=\"697\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2025\/03\/2s.png 641w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2025\/03\/2s-211x300.png 211w\" sizes=\"(max-width: 490px) 100vw, 490px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"wp-image-18269 alignleft\" src=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2025\/03\/3s.png\" alt=\"\" width=\"490\" height=\"700\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2025\/03\/3s.png 638w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2025\/03\/3s-210x300.png 210w\" sizes=\"(max-width: 490px) 100vw, 490px\" \/><\/p><p>\u00a0<\/p><p>\u00a0<\/p>                    <\/div>\n\t\t        \n                    <div id=\"selected-publications-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"selected-publications-tab\">\n\t\t\t\t        <ul><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36599901\/\">Profilin 1 deficiency drives mitotic defects and reduces genome stability.<\/a> <strong>Scotto di Carlo F<\/strong>, Russo S, Muyas F, Mangini M, Garribba L, Pazzaglia L, Genesio R, Biamonte F, De Luca AC, Santaguida S, Scotlandi K, Cort\u00e9s-Ciriano I, Gianfrancesco F. Commun Biol. 2023 Jan 4;6(1):9. doi: 10.1038\/s42003-022-04392-8.<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36918542\/\">A mutation in the ZNF687 gene that is responsible for the severe form of Paget&#8217;s disease of bone causes severely altered bone remodeling and promotes hepatocellular carcinoma onset in a knock-in mouse model.<\/a> Russo S,<strong>Scotto di Carlo F<\/strong>, Maurizi A, Fortunato G, Teti A, Licastro D, Settembre C, Mello T, Gianfrancesco F.Bone Res. 2023 Mar 14;11(1):16. doi: 10.1038\/s41413-023-00250-3.PMID:\u00a036918542<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32502498\/\">The two faces of giant cell tumor of bone.<\/a> <strong>Scotto di Carlo F<\/strong>, Whyte MP, Gianfrancesco F.Cancer Lett. 2020 Oct 1;489:1-8. doi: 10.1016\/j.canlet.2020.05.031. Epub 2020 Jun 2.PMID:32502498<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32106343\/\">ZNF687 Mutations in an Extended Cohort of Neoplastic Transformations in Paget&#8217;s Disease of Bone: Implications for Clinical Pathology.<\/a> <strong>Scotto di Carlo F<\/strong>, Pazzaglia L, Mumm S, Benassi MS, De Chiara A, Franchi A, Parafioriti A, Righi A, Esposito T, Whyte MP, Gianfrancesco F.J Bone Miner Res. 2020 Oct;35(10):1974-1980. doi: 10.1002\/jbmr.3993. Epub 2020 Mar 11.PMID:32106343<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31991009\/\">The Loss of Profilin 1 Causes Early Onset Paget&#8217;s Disease of Bone.<\/a> <strong>Scotto di Carlo F<\/strong>, Pazzaglia L, Esposito T, Gianfrancesco F.J Bone Miner Res. 2020 Aug;35(8):1387-1398. doi: 10.1002\/jbmr.3964. Epub 2020 Feb 19.PMID:31991009<\/li><\/ul>                    <\/div>\n\t\t        \n                    <div id=\"professional-experience-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"professional-experience-tab\">\n\t\t\t\t        <p>Federica joined Fernando Gianfrancesco\u2019s\u00a0<em>Bone Diseases and Tumors<\/em>\u00a0laboratory in 2014 to complete her master&#8217;s thesis. In 2018, she earned a PhD in Molecular Life Sciences from the University of Campania\u00a0<em>Luigi Vanvitelli<\/em>. During her doctoral research, she applied next-generation sequencing technologies and identified the loss of Profilin 1 as a recurrent feature in osteosarcomas, highly aggressive tumors characterized by significant genomic instability. This discovery led her to explore the field of genome integrity regulation, where she uncovered a novel role for Profilin 1 in ensuring mitotic fidelity through cytoskeletal regulation.<\/p><p>With the support of an AIRC postdoctoral fellowship, Federica joined Renata Basto\u2019s\u00a0<em>Biology of Centrosomes and Genomic Instability<\/em>\u00a0laboratory at Institut Curie (Paris, France), where she investigated the impact of Profilin 1 inactivation on cell cycle regulation and DNA damage response checkpoints.<\/p><p>Currently, her research at IGB focuses on defining the mechanistic role of Profilin 1 in cell cycle progression and metabolic regulation, as well as dissecting the underlying mechanisms disrupted in cancer.<\/p><p>Federica has received several national and international awards, including the\u00a0<em>New Investigator Award<\/em>\u00a0from the European Calcified Tissue Society (ECTS) and the\u00a0<em>Young Investigator Award<\/em>\u00a0from the American Society for Bone and Mineral Research (ASBMR). She was also awarded a postdoctoral fellowship from Fondazione Umberto Veronesi and has been the Principal Investigator of two projects funded by ECTS and the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases (SIOMMMS), which aimed to further investigate the role of Profilin 1 in maintaining genome integrity in osteosarcoma.<\/p><p>\u00a0<\/p>                    <\/div>\n\t\t                    <\/div>\n        <\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Federica Scotto di Carlo Researcher +390816132221 \u00a0\u00a0 federica.scotto@igb.cnr.it\u00a0 Genetics, Genomics and Epigenetics of Diseases\/Molecular Oncology Keywords: Genome instability; osteosarcoma; cell cycle; mitosis; cancer metabolism \u00a0 \u00a0\u00a0 Orcid X-twitter Linkedin Research Interest Selected Publications Professional Experience Federica is a researcher in Fernando Gianfrancesco\u2019s Bone Diseases and Tumors laboratory. Her main scientific interest is understanding the molecular [&hellip;]<\/p>\n","protected":false},"author":45,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"class_list":["post-18237","page","type-page","status-publish","czr-hentry"],"_links":{"self":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages\/18237","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/users\/45"}],"replies":[{"embeddable":true,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/comments?post=18237"}],"version-history":[{"count":13,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages\/18237\/revisions"}],"predecessor-version":[{"id":18285,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages\/18237\/revisions\/18285"}],"wp:attachment":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/media?parent=18237"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}