{"id":18327,"date":"2025-05-21T09:47:51","date_gmt":"2025-05-21T07:47:51","guid":{"rendered":"https:\/\/www.igb.cnr.it\/?page_id=18327"},"modified":"2025-10-14T16:54:14","modified_gmt":"2025-10-14T14:54:14","slug":"salvatore-fioriniello","status":"publish","type":"page","link":"https:\/\/www.igb.cnr.it\/index.php\/salvatore-fioriniello\/","title":{"rendered":"Salvatore Fioriniello"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"18327\" class=\"elementor elementor-18327\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-29d7e4e5 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"29d7e4e5\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-39c1933e\" data-id=\"39c1933e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-dc35ed1 elementor-widget elementor-widget-bdt-member\" data-id=\"dc35ed1\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;none&quot;}\" data-widget_type=\"bdt-member.bdt-phaedra\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"bdt-member skin-phaedra bdt-transition-toggle\">\n\t\t\t\n\t\t\t\t<div class=\"bdt-member-photo-wrapper\">\n\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"bdt-member-photo\">\n\t\t\t\t\t\t<div class=\"\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/11\/DSC_0115.jpg\" title=\"DSC_0115\" alt=\"DSC_0115\" loading=\"lazy\" \/>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t<\/div>\n\n\t\t\t\n\t\t\t<div class=\"bdt-member-overlay bdt-overlay-default bdt-position-cover bdt-transition-fade bdt-position-z-index\">\n\t\t\t\t<div class=\"bdt-member-desc bdt-position-center bdt-text-center\">\n\t\t\t\t\t<div class=\"bdt-member-content bdt-transition-slide-top-small\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-31f45cb9\" data-id=\"31f45cb9\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5301ed90 elementor-widget elementor-widget-heading\" data-id=\"5301ed90\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Salvatore Fioriniello<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-15ae93db elementor-widget elementor-widget-text-editor\" data-id=\"15ae93db\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3><strong><span style=\"color: #006293;\">Technologist<\/span><\/strong><\/h3><p><strong><img decoding=\"async\" class=\"alignnone wp-image-2318\" src=\"http:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona.png\" alt=\"\" width=\"17\" height=\"17\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona.png 512w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-300x300.png 300w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-150x150.png 150w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-270x250.png 270w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-510x510.png 510w\" sizes=\"(max-width: 17px) 100vw, 17px\" \/>\u00a0 +39 081 6132607 \u00a0\u00a0 <\/strong><strong><img decoding=\"async\" class=\"alignnone wp-image-2317\" src=\"http:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png\" alt=\"\" width=\"19\" height=\"19\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png 512w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-300x300.png 300w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-150x150.png 150w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-270x250.png 270w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-510x510.png 510w\" sizes=\"(max-width: 19px) 100vw, 19px\" \/>\u00a0 salvatore.fioriniello@igb.cnr.it<\/strong><\/p><div><p><strong>Genetics, Genomics and Epigenetics of Diseases<\/strong><\/p><p><strong>Keywords: <\/strong><strong><br \/><\/strong><\/p><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0b6e642 e-grid-align-left elementor-shape-rounded elementor-grid-0 elementor-widget elementor-widget-social-icons\" data-id=\"0b6e642\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"social-icons.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-social-icons-wrapper elementor-grid\" role=\"list\">\n\t\t\t\t\t\t\t<span class=\"elementor-grid-item\" role=\"listitem\">\n\t\t\t\t\t<a class=\"elementor-icon elementor-social-icon elementor-social-icon-github elementor-animation-grow-rotate elementor-repeater-item-771af57\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-screen-only\">Github<\/span>\n\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fab fa-github\"><\/i>\t\t\t\t\t<\/a>\n\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<span class=\"elementor-grid-item\" role=\"listitem\">\n\t\t\t\t\t<a class=\"elementor-icon elementor-social-icon elementor-social-icon-twitter elementor-animation-grow-rotate elementor-repeater-item-6344322\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-screen-only\">Twitter<\/span>\n\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fab fa-twitter\"><\/i>\t\t\t\t\t<\/a>\n\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<span class=\"elementor-grid-item\" role=\"listitem\">\n\t\t\t\t\t<a class=\"elementor-icon elementor-social-icon elementor-social-icon- elementor-animation-grow-rotate elementor-repeater-item-021f1e1\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-screen-only\"><\/span>\n\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" 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class=\"eael-tabs-nav\">\n                <ul class=\"\" role=\"tablist\">\n                                            <li id=\"research-interest\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"research-interest-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >Research Interest<\/span>                                                    <\/li>\n                                            <li id=\"selected-publications\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"selected-publications-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >Selected Publications<\/span>                                                    <\/li>\n                                            <li id=\"professional-experience\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"false\" data-tab=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"professional-experience-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >Professional Experience<\/span>                                                    <\/li>\n                                    <\/ul>\n            <\/div>\n            \n            <div class=\"eael-tabs-content\">\n\t\t        \n                    <div id=\"research-interest-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"research-interest-tab\">\n\t\t\t\t        <p>Dr. S. Fioriniello has experience in human genetic, epigenetic and epigenomic fields.<\/p><p>From 2014, he studied the molecular mechanisms altered in the Rett syndrome (RTT, OMIM 312750), employing genetic and epigenetic approaches taking advantage of both <em>in vitro<\/em> cellular systems and <em>in vivo <\/em>mouse models of the disease.<\/p><p>His current research interest is focused on the study of the mechanisms underlying neuronal deregulation of sphingolipid (SL) metabolism in RTT, and the identification of new therapeutic candidates capable to counteract SL metabolic imbalance and mitigate RTT symptoms, through the use of drug repurposing strategies.<\/p>                    <\/div>\n\t\t        \n                    <div id=\"selected-publications-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"selected-publications-tab\">\n\t\t\t\t        <p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40057542\/\">Green forage impacts on the DNA methylation in the ruminal wall of Italian mediterranean dairy buffaloes <\/a>Fioriniello S, Salzano A, Bifulco G, Aiese Cigliano R, Della Ragione F, Campanile G. Sci Rep. 2025 Mar 8;15(1):8074. doi: 10.1038\/s41598-025-91969-y.<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38456444\/\">Stroke Causes DNA Methylation at <em>Ncx1<\/em> Heart Promoter in the Brain Via DNMT1\/MeCP2\/REST Epigenetic Complex. \u00a0<\/a>Guida N, Serani A, Sanguigno L, Mascolo L, Cuomo O, Fioriniello S, Marano D, Ragione FD, Anzilotti S, Brancaccio P, Molinaro P, Pignataro G, Annunziato L, Formisano L. J Am Heart Assoc. 2024 Mar 19;13(6):e030460. doi: 10.1161\/JAHA.123.030460. Epub 2024 Mar 8.<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39040103\/\">A novel iPSC-based model of ICF syndrome subtype 2 recapitulates the molecular phenotype of ZBTB24 deficiency. <\/a>Lullo V, Cecere F, Batti S, Allegretti S, Morone B, Fioriniello S, Pisapia L, Genesio R, Della Ragione F, Giardino G, Pignata C, Riccio A, Matarazzo MR, Strazzullo M. Front Immunol. 2024 Jul 8;15:1419748. doi: 10.3389\/fimmu.2024.1419748.<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36941576\/\">Transcriptomic profiles of the ruminal wall in Italian Mediterranean dairy buffaloes fed green forage. <\/a>Salzano A, Fioriniello S, D&#8217;Onofrio N, Balestrieri ML, Aiese Cigliano R, Neglia G, Della Ragione F, Campanile G. BMC Genomics. 2023 Mar 20;24(1):133. doi: 10.1186\/s12864-023-09215-6.<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37513899\/\">The Carnitine Palmitoyltransferase 1A Inhibitor Teglicar Shows Promising Antitumour Activity against Canine Mammary Cancer Cells by Inducing Apoptosis. <\/a>Cacciola NA, Sepe F, Fioriniello S, Petillo O, Margarucci S, Scivicco M, Peluso G, Balestrieri A, Bifulco G, Restucci B, Severino L. Pharmaceuticals (Basel). 2023 Jul 10;16(7):987. doi: 10.3390\/ph16070987.<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37189354\/\">Blood-Brain Barrier Integrity Is Perturbed in a <em>Mecp2<\/em>-Null Mouse Model of Rett Syndrome. \u00a0<\/a>Pepe G, Fioriniello S, Marracino F, Capocci L, Maglione V, D&#8217;Esposito M, Di Pardo A, Della Ragione F. Biomolecules. 2023 Mar 28;13(4):606. doi: 10.3390\/biom13040606.<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36828588\/\">The aberrant epigenome of <em>DNMT3B<\/em>-mutated ICF1 patient iPSCs is amenable to correction, with the exception of a subset of regions with H3K4me3- and\/or CTCF-based epigenetic memory. \u00a0<\/a>Poondi Krishnan V, Morone B, Toubiana S, Krzak M, Fioriniello S, Della Ragione F, Strazzullo M, Angelini C, Selig S, Matarazzo MR. Genome Res. 2023 Feb;33(2):169-183. doi: 10.1101\/gr.276986.122.<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35998113\/\">NPPA\/atrial natriuretic peptide is an extracellular modulator of autophagy in the heart. <\/a>Forte M, Marchitti S, Di Nonno F, Stanzione R, Schirone L, Cotugno M, Bianchi F, Schiavon S, Raffa S, Ranieri D, Fioriniello S, Della Ragione F, Torrisi MR, Carnevale R, Valenti V, Versaci F, Frati G, Vecchione C, Volpe M, Rubattu S, Sciarretta S. Autophagy. 2023 Apr;19(4):1087-1099. doi: 10.1080\/15548627.2022.2115675. Epub 2022 Sep 6.\u00a0<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34226608\/\">Zfp57 inactivation illustrates the role of ICR methylation in imprinted gene expression during neural differentiation of mouse ESCs. <\/a>Acurzio B, Verma A, Polito A, Giaccari C, Cecere F, Fioriniello S, Della Ragione F, Fico A, Cerrato F, Angelini C, Feil R, Riccio A. Sci Rep. 2021 Jul 5;11(1):13802. doi: 10.1038\/s41598-021-93297-3.<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34209228\/\">Transcriptomic and Epigenomic Landscape in Rett Syndrome<\/a>. Marano D, Fioriniello S, D\u2019Esposito M, Della Ragione F. Biomolecules. 2021 Jun 30;11(7):967. DOI: 10.3390\/biom11070967. (Cover page).<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33296675\/\">MeCP2 and Major Satellite Forward RNA Cooperate for Pericentric Heterochromatin Organization<\/a>. Fioriniello S, Csukonyi E, Marano D, Brancaccio A, Madonna M, Zarrillo C, Romano A, Marracino F, Matarazzo MR, D\u2019Esposito M and Della Ragione F. Stem Cell Reports. 2020 Dec 8;15(6):1317-1332. doi: 10.1016\/j.stemcr.2020.11.006.<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32481609\/\">Epigenetic Factors That Control Pericentric Heterochromatin Organization in Mammals<\/a>. Fioriniello S, Marano D, Fiorillo F, D\u2019Esposito M, <strong>Della Ragione F<\/strong><strong>. <\/strong>Genes. 2020 May 28;11(6):E595. DOI: 10.3390\/genes11060595.<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31671722\/\">ATRX contributes to MeCP2-mediated pericentric heterochromatin organization during neural differentiation<\/a>. Marano D, Fioriniello S, Fiorillo F, Gibbons R, D\u2019Esposito M and <strong>Della Ragione F<\/strong><strong>. <\/strong>Int J Mol Sci. 2019 Oct 29;20(21). DOI: 10.3390\/ijms20215371. <strong>(Cover page).<\/strong><\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29282205\/\">Glycosphingolipid metabolic reprogramming drives neural differentiation<\/a>. Russo D<strong>, Della Ragione F,<\/strong> Rizzo R, Sugiyama E, Scalabr\u00ec F, Hori K, Capasso S, Sticco L, Fioriniello S, De Gregorio R, Granata I, Guarracino MR, Maglione V, Johannes L, Bellenchi GC, Hoshino M, Setou M, D\u2019Esposito M, Luini A, D\u2019Angelo G. EMBO J. 2017 Dec 27. ii: e97674. DOI: 10.15252\/embj.201797674<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28640254\/\">Reduced brain UCP2 expression mediated by microRNA-503 contributes to increased stroke susceptibility in the high-salt fed stroke-prone spontaneously hypertensive rat. <\/a>Rubattu S, Stanzione R, Bianchi F, Cotugno M, Forte M, Della Ragione F, Fioriniello S, D&#8217;Esposito M, Marchitti S, Madonna M, Baima S, Morelli G, Sciarretta S, Sironi L, Gelosa P, Volpe M. Cell Death Dis. 2017 Jun 22;8(6):e2891. doi: 10.1038\/cddis.2017.278.\u00a0<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27296483\/\">MECP2 a multi-talented modulator of chromatin architecture<\/a>.<strong>Della Ragione, F<\/strong><strong>.,<\/strong> Vacca, M., Fioriniello, S., Pepe, G. and D\u2019Esposito, M.Brief Funct Genomics. 2016 Nov;15(6):420-431. Epub 2016 Jun 12. DOI: 10.1093\/bfgp\/elw023<\/p><p>\u00a0<\/p>                    <\/div>\n\t\t        \n                    <div id=\"professional-experience-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"professional-experience-tab\">\n\t\t\t\t        <p><strong><span style=\"color: #800000;\">Current Position<\/span><\/strong><\/p><p>May 2025 \u2013 Technologist , IGB-ABT, CNR, Naples, Italy.<\/p><p><span style=\"color: #800000;\"><strong>Education<\/strong><\/span><\/p><p>December 2019 \u2013 Ph.D. in Molecular Life Science, Universit\u00e0 degli Studi della Campania \u201c<em>Luigi Vanvitelli<\/em>\u201d, Caserta (Italy).<\/p><p>March 2016 \u2013 MSc degree &#8220;<em>summa cum laude<\/em>&#8221; in Biological Sciences, University of Naples <em>&#8220;Federico II&#8221;<\/em>.<\/p><p><span style=\"color: #800000;\"><strong>Research Appointments<\/strong><\/span><\/p><p>October 2023 \u2013 May 2025. Laboratory manager, Department of <em>\u201cChimica e Biologia A. Zambelli\u201d<\/em>, University of Salerno (Italy).<\/p><p>November 2019 \u2013 October 2023. Post-doctoral fellow, IGB-ABT, CNR, Naples.<\/p><p>November 2016 \u2013 October 2019. PhD student, IGB-ABT, CNR, Naples.<\/p><p>March 2016 \u2013 October 2016. research fellow at IGB-ABT, Naples, Italy.<\/p><p>November 2014 \u2013 March 2016. Undergraduate student, IGB-ABT, CNR, Naples.<\/p>                    <\/div>\n\t\t                    <\/div>\n        <\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Salvatore Fioriniello Technologist \u00a0 +39 081 6132607 \u00a0\u00a0 \u00a0 salvatore.fioriniello@igb.cnr.it Genetics, Genomics and Epigenetics of Diseases Keywords: Github Twitter Orcid Research Interest Selected Publications Professional Experience Dr. S. Fioriniello has experience in human genetic, epigenetic and epigenomic fields. From 2014, he studied the molecular mechanisms altered in the Rett syndrome (RTT, OMIM 312750), employing genetic [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"class_list":["post-18327","page","type-page","status-publish","czr-hentry"],"_links":{"self":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages\/18327","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/comments?post=18327"}],"version-history":[{"count":13,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages\/18327\/revisions"}],"predecessor-version":[{"id":18921,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages\/18327\/revisions\/18921"}],"wp:attachment":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/media?parent=18327"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}