{"id":2357,"date":"2021-02-24T16:05:09","date_gmt":"2021-02-24T15:05:09","guid":{"rendered":"https:\/\/www.igb.cnr.it\/?page_id=2357"},"modified":"2023-09-20T13:03:17","modified_gmt":"2023-09-20T11:03:17","slug":"luca-di-giovannantonio","status":"publish","type":"page","link":"https:\/\/www.igb.cnr.it\/index.php\/luca-di-giovannantonio\/","title":{"rendered":"Luca Di Giovannantonio"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2357\" class=\"elementor elementor-2357\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6352aa9f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6352aa9f\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-6d47e912\" data-id=\"6d47e912\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6e53afc2 elementor-widget elementor-widget-bdt-member\" data-id=\"6e53afc2\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;none&quot;}\" data-widget_type=\"bdt-member.bdt-phaedra\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"bdt-member skin-phaedra bdt-transition-toggle\">\n\t\t\t\n\t\t\t\t<div class=\"bdt-member-photo-wrapper\">\n\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"bdt-member-photo\">\n\t\t\t\t\t\t<div class=\"\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/10\/DSC_0035.jpg\" title=\"DSC_0035\" alt=\"DSC_0035\" loading=\"lazy\" \/>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t<\/div>\n\n\t\t\t\n\t\t\t<div class=\"bdt-member-overlay bdt-overlay-default bdt-position-cover bdt-transition-fade bdt-position-z-index\">\n\t\t\t\t<div class=\"bdt-member-desc bdt-position-center bdt-text-center\">\n\t\t\t\t\t<div class=\"bdt-member-content bdt-transition-slide-top-small\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-52196921\" data-id=\"52196921\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1462bc31 elementor-widget elementor-widget-heading\" data-id=\"1462bc31\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Luca Di Giovannantonio<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-580e04a2 elementor-widget elementor-widget-spacer\" data-id=\"580e04a2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-53a4984f elementor-widget elementor-widget-text-editor\" data-id=\"53a4984f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3><strong><span style=\"color: #006293;\">Researcher<br \/><\/span><\/strong><\/h3><div><p><strong>\u00a0<img decoding=\"async\" class=\"alignnone wp-image-2318\" src=\"http:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona.png\" alt=\"\" width=\"17\" height=\"17\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona.png 512w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-300x300.png 300w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-150x150.png 150w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-270x250.png 270w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-510x510.png 510w\" sizes=\"(max-width: 17px) 100vw, 17px\" \/> +39 081 6132 443\u00a0 <img decoding=\"async\" class=\"alignnone wp-image-2317\" src=\"http:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png\" alt=\"\" width=\"19\" height=\"19\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png 512w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-300x300.png 300w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-150x150.png 150w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-270x250.png 270w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-510x510.png 510w\" sizes=\"(max-width: 19px) 100vw, 19px\" \/> luca.digiovannantonio@igb.cnr.it<\/strong><\/p><p class=\"elementor-heading-title elementor-size-default\"><span style=\"color: #000000;\"><strong><span class=\"cretive-button-text\">Embryonic Development and Biology of Stem Cells &#8211; Neurobiology and Brain Functioning<\/span><\/strong><\/span><\/p><p><strong>Keywords: <\/strong>Developmental Neurobiology, Parkinson Disease, gene targeting<\/p><p>\u00a0<\/p><\/div><div class=\"notranslate\" style=\"all: initial;\">\u00a0<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7c1af6a9 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7c1af6a9\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-46f3dbf1\" data-id=\"46f3dbf1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-71cf60ec elementor-widget elementor-widget-eael-adv-tabs\" data-id=\"71cf60ec\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"eael-adv-tabs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t        <div data-scroll-on-click=\"no\" data-scroll-speed=\"300\" id=\"eael-advance-tabs-71cf60ec\" class=\"eael-advance-tabs eael-tabs-horizontal eael-tab-auto-active \" data-tabid=\"71cf60ec\">\n            <div class=\"eael-tabs-nav\">\n                <ul class=\"\" role=\"tablist\">\n                                            <li id=\"research-interest\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"research-interest-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >Research Interest<\/span>                                                    <\/li>\n                                            <li id=\"selected-publications\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"selected-publications-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >Selected Publications<\/span>                                                    <\/li>\n                                            <li id=\"professional-experience\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"false\" data-tab=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"professional-experience-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >Professional Experience<\/span>                                                    <\/li>\n                                    <\/ul>\n            <\/div>\n            \n            <div class=\"eael-tabs-content\">\n\t\t        \n                    <div id=\"research-interest-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"research-interest-tab\">\n\t\t\t\t        <ul><li>Mechanisms underlying proliferation and differentiation of mesencephalic dopaminergic progenitors and specification of neuron subtype identity in Ventral Tegmental Area and Substantia Nigra pars compacta.<\/li><li>Possible role of Otx1 gene in the onset and progression of desmoplastic medulloblastomas.<\/li><li>Study of mechanism that determines epiblast contribution to germline and somatic lineage.<\/li><li>Generation and characterization of humanized mouse models reproducing genetic variants found in families affected by late onset Parkinson\u2019s disease.<\/li><\/ul>                    <\/div>\n\t\t        \n                    <div id=\"selected-publications-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"selected-publications-tab\">\n\t\t\t\t        <p>Gialluisi A, Reccia MG, Modugno N, Nutile T, Lombardi A, <strong>Di Giovannantonio LG<\/strong>, Pietracupa S, Ruggiero D, Scala S, Gambardella S; International Parkinson\u2019s Disease Genomics Consortium (IPDGC), Iacoviello L, Gianfrancesco F, Acampora D, D&#8217;Esposito M, Simeone A, Ciullo M, Esposito T. <em>Identification of sixteen novel candidate genes for late onset Parkinson\u2019s disease.<\/em> <strong>Molecular Neurodegeneration<\/strong>, 16(1):35 (<strong>2021<\/strong>).<\/p><p><strong>Di Giovannantonio LG<\/strong>, Acampora D, Omodei D, Nigro V, Barba P, Barbieri E, Chambers I, Simeone A. <em>Direct repression of Nanog and Oct4 by OTX2 modulates the contribution of epiblast-derived cells to germline and somatic lineage<\/em>. <strong>Development<\/strong>, 15;148(10) (<strong>2021<\/strong>)<\/p><p>Di Malta C, Siciliano D, Calcagni A, Monfregola J, Punzi S, Pastore N, Eastes AN, Davis O, De Cegli R, Zampelli A, <strong>Di Giovannantonio LG<\/strong>, Nusco E, Platt N, Guida A, Ogmundsdottir MH, Lanfrancone L, Perera RM, Zoncu R, Pelicci PG, Settembre C, Ballabio A. <em>Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth<\/em>. <strong>Science,<\/strong> 356(6343), 1188-1192 (<strong>2017<\/strong>).<\/p><p><strong>Di Giovannantonio LG, <\/strong>Di Salvio M, Omodei D, Prakash N, Wolfgang W, Pierani\u00a0 A, Acampora D, Simeone A. <em>Otx2 cell-autonomously determines dorsal mesencephalon versus cerebellum fate independently of the\u00a0 isthmic organizing activity<\/em>. <strong>Development<\/strong> 141(2), 377-88 (<strong>2014<\/strong>).<\/p><p><strong>Di Giovannantonio LG<\/strong>, Di Salvio M, Acampora D, Prakash N, Wolfgang W, Simeone A. <em>Otx2 selectively controls the neurogenesis of specific neuronal subtypes of the ventral tegmental area and compensates En1-dependent neuronal loss and MPTP vulnerability<\/em>. <strong>Dev Biol<\/strong><strong>.<\/strong>\u00a0 373, 176-183 (<strong>2013<\/strong>).<\/p><p>Garc\u00eca-Moreno F, Pedraza M, <strong>Di Giovannantonio LG<\/strong>, Di Salvio M, L\u00f2pez-Mascaraque L, Simeone A, &amp; De Carlos JA. <em>A neuronal migratory pathway crossing from diencephalon to telencephalon populates amygdala nuclei<\/em>.<strong>Nat Neurosci.<\/strong> 13, 680-689 (<strong>2010<\/strong>)<\/p><p>*Di Salvio M, *<strong>Di Giovannantonio LG<\/strong>, Acampora D, Prosperi R, Omodei D, Prakash N, Wurst W, Simeone A. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21057506\"><em>Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP<\/em>.<\/a> <strong>Nat Neurosci.<\/strong> 13, 1481-1488 (<strong>2010<\/strong>) * Co-first authors<\/p>                    <\/div>\n\t\t        \n                    <div id=\"professional-experience-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"professional-experience-tab\">\n\t\t\t\t        <p>2019 to present: IGB-CNR Researcher<\/p><p>2015 to present: IGB Mouse Modeling Facility staff<\/p><p>2015-2018: IGB-CNR Technologist<\/p><p>2014-2015: Telethon Institute Of Genetics And Medicine research fellow<\/p><p>2005-2013: CEINGE Biotecnologie Avanzate research fellow<\/p>                    <\/div>\n\t\t                    <\/div>\n        <\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Luca Di Giovannantonio Researcher \u00a0 +39 081 6132 443\u00a0 luca.digiovannantonio@igb.cnr.it Embryonic Development and Biology of Stem Cells &#8211; Neurobiology and Brain Functioning Keywords: Developmental Neurobiology, Parkinson Disease, gene targeting \u00a0 \u00a0 Research Interest Selected Publications Professional Experience Mechanisms underlying proliferation and differentiation of mesencephalic dopaminergic progenitors and specification of neuron subtype identity in Ventral Tegmental [&hellip;]<\/p>\n","protected":false},"author":69,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"class_list":["post-2357","page","type-page","status-publish","czr-hentry"],"_links":{"self":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages\/2357","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/users\/69"}],"replies":[{"embeddable":true,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/comments?post=2357"}],"version-history":[{"count":28,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages\/2357\/revisions"}],"predecessor-version":[{"id":15944,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages\/2357\/revisions\/15944"}],"wp:attachment":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/media?parent=2357"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}