{"id":2404,"date":"2021-02-25T11:23:38","date_gmt":"2021-02-25T10:23:38","guid":{"rendered":"https:\/\/www.igb.cnr.it\/?page_id=2404"},"modified":"2025-10-16T17:43:38","modified_gmt":"2025-10-16T15:43:38","slug":"gabriella-lania","status":"publish","type":"page","link":"https:\/\/www.igb.cnr.it\/index.php\/gabriella-lania\/","title":{"rendered":"Gabriella Lania"},"content":{"rendered":"\t\t
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Gabriella Lania<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Technologist<\/span><\/strong><\/h3>

\"\" + 39 081 6132230 \"\" gabriella.lania@igb.cnr.it<\/strong><\/p>

Embryonic Development and Biology of Stem Cells<\/span><\/strong><\/span><\/p>

Keywords:\u00a0<\/strong><\/p><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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  • \n \n \n \n Research Interest<\/span> <\/li>\n
  • \n \n \n \n Selected Publications<\/span> <\/li>\n
  • \n \n \n \n Professional Experience<\/span> <\/li>\n
  • \n \n \n \n Associated People<\/span> <\/li>\n <\/ul>\n <\/div>\n \n
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    My research focuses on the molecular mechanisms underlying embryonic development, with particular emphasis on the transcription factor TBX1 and its role embryo development and 22q11.2 deletion syndrome. Using Tbx1 mutant mouse models and stem-cell\u2013based systems, I have demonstrated that TBX1 regulates cardiovascular differentiation by modulating multiple signaling pathways, including FGF8 response, Vegfr2 repression, and tissue regionalization. More recently, I identified vitamin B12 as a potential therapeutic agent capable of partially rescuing developmental and metabolic defects in Tbx1 mutants, restoring brain metabolomic balance and correcting associated behavioral phenotypes. These findings highlight a novel link between TBX1 dosage, metabolism, and gut development. Currently my research is aimed to: (1) identify the signals regulating tissue regionalisation during gut embryogenesis in Tbx1 mutant; (2) define how these cues shape the gut environment, with the ultimate goal of uncovering new therapeutic strategies for congenital disorders.<\/p>

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    <\/span>
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    Ilaria<\/span> Aurigemma<\/span><\/div>
    PhD student<\/div>

    \"\"<\/strong>+390816132 226 \"\" ilaria.aurigemma@igb.cnr.it<\/p>

    Dottorato di Ricerca in Medicina Molecolare e Biotecnologie Mediche Universit\u00e0 Federico II<\/p>

    Project Title:<\/strong> Identifying critical regulatory factors during cardiopharyngeal mesoderm differentiation into endothelial cells.<\/em>
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    Gabriella Lania Technologist + 39 081 6132230 gabriella.lania@igb.cnr.it Embryonic Development and Biology of Stem Cells Keywords:\u00a0 Research Interest Selected Publications Professional Experience Associated People My research focuses on the molecular mechanisms underlying embryonic development, with particular emphasis on the transcription factor TBX1 and its role embryo development and 22q11.2 deletion syndrome. Using Tbx1 mutant mouse […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"class_list":["post-2404","page","type-page","status-publish","czr-hentry"],"_links":{"self":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages\/2404","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/comments?post=2404"}],"version-history":[{"count":26,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages\/2404\/revisions"}],"predecessor-version":[{"id":18933,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages\/2404\/revisions\/18933"}],"wp:attachment":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/media?parent=2404"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}