{"id":2452,"date":"2021-03-02T13:05:25","date_gmt":"2021-03-02T12:05:25","guid":{"rendered":"https:\/\/www.igb.cnr.it\/?page_id=2452"},"modified":"2023-09-20T13:15:14","modified_gmt":"2023-09-20T11:15:14","slug":"maria-giuseppina-miano","status":"publish","type":"page","link":"https:\/\/www.igb.cnr.it\/index.php\/maria-giuseppina-miano\/","title":{"rendered":"Maria Giuseppina Miano"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2452\" class=\"elementor elementor-2452\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1a291fe6 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1a291fe6\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-42414802\" data-id=\"42414802\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-10178b8d elementor-widget elementor-widget-bdt-member\" data-id=\"10178b8d\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;none&quot;}\" data-widget_type=\"bdt-member.bdt-phaedra\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"bdt-member skin-phaedra bdt-transition-toggle\">\n\t\t\t\n\t\t\t\t<div class=\"bdt-member-photo-wrapper\">\n\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"bdt-member-photo\">\n\t\t\t\t\t\t<div class=\"\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/10\/DSC_0238.jpg\" title=\"DSC_0238\" alt=\"DSC_0238\" loading=\"lazy\" \/>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t<\/div>\n\n\t\t\t\n\t\t\t<div class=\"bdt-member-overlay bdt-overlay-default bdt-position-cover bdt-transition-fade bdt-position-z-index\">\n\t\t\t\t<div class=\"bdt-member-desc bdt-position-center bdt-text-center\">\n\t\t\t\t\t<div class=\"bdt-member-content bdt-transition-slide-top-small\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-6c4bbc57\" data-id=\"6c4bbc57\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-28090e3 elementor-widget elementor-widget-heading\" data-id=\"28090e3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Maria Giuseppina Miano<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4f6aab50 elementor-widget elementor-widget-text-editor\" data-id=\"4f6aab50\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3><strong><span style=\"color: #006293;\">Senior Researcher<\/span><\/strong><\/h3><div><p><strong><img decoding=\"async\" class=\"alignnone wp-image-2318\" src=\"http:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona.png\" alt=\"\" width=\"17\" height=\"17\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona.png 512w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-300x300.png 300w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-150x150.png 150w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-270x250.png 270w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-510x510.png 510w\" sizes=\"(max-width: 17px) 100vw, 17px\" \/> +39 081 6132261-445 \u00a0 <img decoding=\"async\" class=\"alignnone wp-image-2317\" src=\"http:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png\" alt=\"\" width=\"19\" height=\"19\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png 512w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-300x300.png 300w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-150x150.png 150w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-270x250.png 270w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-510x510.png 510w\" sizes=\"(max-width: 19px) 100vw, 19px\" \/> mariag.miano@igb.cnr.it<\/strong><\/p><p class=\"elementor-heading-title elementor-size-default\"><strong>Neurobiology and Brain Functioning\/Genetics, Genomics and Epigenetics of Diseases<\/strong><\/p><p><strong>Keywords: <\/strong>Malformations of cortical development (MCDs), developmental epileptic encephalopathies (DEE), intellectual disability (ID) and autism spectrum disorders (ASD); ARX-KDM5C axis; animal models; omic-strategies; drug-discovery.<\/p><p><strong>\u00a0\u00a0\u00a0 <a href=\"https:\/\/www.facebook.com\/mariapia.miano\/\"><img decoding=\"async\" class=\"alignnone wp-image-13911\" src=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/01\/images-1.png\" alt=\"\" width=\"27\" height=\"27\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/01\/images-1.png 225w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/01\/images-1-150x150.png 150w\" sizes=\"(max-width: 27px) 100vw, 27px\" \/><\/a>\u00a0 <img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-12429\" src=\"http:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/01\/20160903181541Twitter_bird_logo-150x150.png\" alt=\"\" width=\"27\" height=\"27\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/01\/20160903181541Twitter_bird_logo-150x150.png 150w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/01\/20160903181541Twitter_bird_logo-300x300.png 300w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/01\/20160903181541Twitter_bird_logo-1024x1024.png 1024w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/01\/20160903181541Twitter_bird_logo-768x768.png 768w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/01\/20160903181541Twitter_bird_logo-1536x1536.png 1536w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/01\/20160903181541Twitter_bird_logo-2048x2048.png 2048w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/01\/20160903181541Twitter_bird_logo-700x700.png 700w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/01\/20160903181541Twitter_bird_logo-510x510.png 510w\" sizes=\"(max-width: 27px) 100vw, 27px\" \/> Twitter:<\/strong>\u00a0 <a href=\"https:\/\/twitter.com\/mariapiashiva\">Personal<\/a> &#8211; <a href=\"https:\/\/twitter.com\/Mianolab\">Lab<\/a><\/p><\/div><div id=\"drum-screenshare-extension\" style=\"display: none;\">1.0.0.20<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-119b2260 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"119b2260\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-214077f8\" data-id=\"214077f8\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2d87f31a elementor-widget elementor-widget-eael-adv-tabs\" data-id=\"2d87f31a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"eael-adv-tabs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t        <div data-scroll-on-click=\"no\" data-scroll-speed=\"300\" id=\"eael-advance-tabs-2d87f31a\" class=\"eael-advance-tabs eael-tabs-horizontal eael-tab-auto-active \" data-tabid=\"2d87f31a\">\n            <div class=\"eael-tabs-nav\">\n                <ul class=\"\" role=\"tablist\">\n                                            <li id=\"research-interest\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"research-interest-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >Research Interest<\/span>                                                    <\/li>\n                                            <li id=\"selected-publications\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"selected-publications-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >Selected Publications<\/span>                                                    <\/li>\n                                            <li id=\"professional-experience\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"false\" data-tab=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"professional-experience-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >Professional Experience<\/span>                                                    <\/li>\n                                            <li id=\"research-group\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"false\" data-tab=\"4\" role=\"tab\" tabindex=\"-1\" aria-controls=\"research-group-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >Research Group<\/span>                                                    <\/li>\n                                    <\/ul>\n            <\/div>\n            \n            <div class=\"eael-tabs-content\">\n\t\t        \n                    <div id=\"research-interest-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"research-interest-tab\">\n\t\t\t\t        <p><strong>Disease-related pathways in NDD disorders<\/strong><\/p><p>A disproportional large number of neurodevelopmental disorders (NDDs) including malformations of cortical development (MCD), developmental epileptic encephalopathies (DEE), intellectual disability (ID) and autism spectrum disorders (ASD) is caused by mutations in genes encoding transcription factors and chromatin modifiers. Our laboratory focuses on the genetic and molecular aspects of a group of X-chromosome genes proved that they belong to an interconnected transcriptional axes underpinning multiple NDDs with clinical overlap.<\/p><p>On the basis of our previous work on rare X-linked NDDs, we apply <em>in vivo<\/em> and <em>in vitro<\/em> approaches and omics technologies to address the following questions:<\/p><ul><li>why different mutations in <em>ARX<\/em> and <em>KDM5C<\/em> cause diverse neuronal phenotypes with shared phenotypic spectra;<\/li><li>which is the pathological role of gene targets of ARX and KDM5C involved in other NDDs.<\/li><\/ul><p><strong>New therapies for <em>ARX<\/em>-related epilepsy<\/strong><\/p><p>Developmental epileptic encephalopathy type 1 (DDE1) associated with <em>ARX<\/em> polyalanine expansions is largely pharmaco-resistant. We are currently investigating the impact of <em>ARX<\/em> polyalanine expansions in the epileptogenesis and how this knowledge could help the discovery of molecular-targeted therapies. We are evaluating a number of small molecules including epi-drugs and biomolecules that allow simultaneous to counteract defects in ARX-dependent paths and stop and\/or ameliorate behavioral epileptic phenotype in <em>Arx<\/em>-polyalanine mice.<\/p><p><strong>Scientific committee:<\/strong><\/p><ul><li><a href=\"http:\/\/www.igb.cnr.it\/19thxlid\/\">http:\/\/www.igb.cnr.it\/19thxlid\/<\/a><\/li><li><a href=\"http:\/\/www.neapolitanbraingroup.it\/\">http:\/\/www.neapolitanbraingroup.it\/<\/a><\/li><li><a href=\"https:\/\/scn2a-italia.it\/\">https:\/\/scn2a-italia.it\/<\/a><\/li><\/ul><p><strong>Guest editor:<\/strong><\/p><p><a href=\"https:\/\/www.frontiersin.org\/research-topics\/22727\/the-rna-world-non-coding-rnas-and-innovative-therapies-in-neurological-disorders\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-12412\" src=\"http:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/01\/The-RNA-World_-Non-Coding-RNAs-and-Innovative-Therapies-in-Neurological-Disorders.png\" alt=\"\" width=\"453\" height=\"132\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/01\/The-RNA-World_-Non-Coding-RNAs-and-Innovative-Therapies-in-Neurological-Disorders.png 620w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/01\/The-RNA-World_-Non-Coding-RNAs-and-Innovative-Therapies-in-Neurological-Disorders-300x87.png 300w\" sizes=\"(max-width: 453px) 100vw, 453px\" \/><\/a><\/p><p><a href=\"https:\/\/www.mdpi.com\/journal\/biomolecules\/special_issues\/neurodevelopmental_ disorders_genetics_epigenetics\" data-wplink-url-error=\"true\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-12416\" src=\"http:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/01\/neurodevelopmental_disorders_genetics_epigenetics_horizontal_dark.png\" alt=\"\" width=\"453\" height=\"260\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/01\/neurodevelopmental_disorders_genetics_epigenetics_horizontal_dark.png 800w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/01\/neurodevelopmental_disorders_genetics_epigenetics_horizontal_dark-300x172.png 300w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/01\/neurodevelopmental_disorders_genetics_epigenetics_horizontal_dark-768x440.png 768w\" sizes=\"(max-width: 453px) 100vw, 453px\" \/><\/a><\/p><div id=\"drum-screenshare-extension\" style=\"display: none\">1.0.0.20<\/div>                    <\/div>\n\t\t        \n                    <div id=\"selected-publications-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"selected-publications-tab\">\n\t\t\t\t        <p>Poeta L, Malacarne M, Padula A, Drongitis D, Verrillo L, Chiariello AM, Nicodemi M, Lioi MB, Piccione M, Coviello D, <strong>Miano MG<\/strong>. Further Delineation of Duplications of <em>ARX <\/em>Locus Detected in Male Patients with Varying Degrees of Intellectual Disability. <em>Int J Mol Sci<\/em>. 2022 Mar 13;23(6):3084<\/p><p>Drongitis D, Caterino M, Verrillo L, Santonicola P, Costanzo M, Poeta L, Attianese B, Barra A, Terrone G, Lioi MB, Paladino S, Di Schiavi E, Costa V, Ruoppolo M, <strong>Miano M. G. <\/strong>Deregulation of microtubule organization and RNA metabolism in <em>Arx<\/em> models for Lissencephaly and Developmental epileptic encephalopathy. <em>Hum Mol Genet. <\/em>2022 Jan 31:ddac028. doi: 10.1093\/hmg\/ddac028.<\/p><p>Poeta L, Padula A, Lioi MB, van Bokhoven H, <strong>Miano MG<\/strong>. Analysis of a Set of KDM5C Regulatory Genes Mutated in Neurodevelopmental Disorders Identifies Temporal Coexpression Brain Signatures. <em>Genes.<\/em> 2021 Jul 18;12(7):1088. doi: 10.3390\/genes12071088.<\/p><p>Verrillo L, Mangano E, Drongitis D, Merelli I, Pischedda F, Piccoli G, Consolandi C, Bordoni R, <strong>Miano MG<\/strong>. A reliable strategy for single-cell RNA sequencing analysis using cryoconserved primary cortical cells. <em>J Neurosci Methods.<\/em> 2021 Jan 1;347:108960. doi: 10.1016\/j.jneumeth.2020.108960.<\/p><p>Petrone P, Giordano G, Vezzoli E, Pensa A, Castaldo G, Graziano V, Sirano F, Capasso E, Quaremba G, Vona A, <strong>Miano MG<\/strong>, Savino S, Niola M. Preservation of neurons in an AD 79 vitrified human brain. <em>PLoS One.<\/em> 2020 Oct 6;15(10):e0240017. doi: 10.1371\/journal.pone.0240017.<\/p><p>Poeta L, Padula A, Attianese B, Valentino M, Verrillo L, Filosa S, Shoubridge C, Barra A, Schwartz CE, Christensen J, van Bokhoven H, Helin K, Lioi MB, Collombat P, Gecz J, Altucci L, Di Schiavi E, <strong>Miano MG<\/strong>. Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders. <em>Hum Mol Genet. <\/em>2019 Dec 15;28(24):4089-4102. doi: 10.1093\/hmg\/ddz254.<\/p><p>Poeta L, Fusco F, Drongitis D, Shoubridge C, Manganelli G, Filosa S, Paciolla M, Courtney M, Collombat P, Lioi MB, Gecz J, Ursini MV, <strong>Miano MG<\/strong>. A regulatory path associated with X-linked intellectual disability and epilepsy links KDM5C to the polyalanine expansions in ARX. <em>Am J Hum Genet.<\/em> 2013 Jan 10;92(1):114-25. doi: 10.1016\/j.ajhg.2012.11.008.<\/p><p>Paciolla M, Boni R, Fusco F, Pescatore A, Poeta L, Ursini MV, Lioi MB, <strong>Miano MG.<\/strong> Nuclear factor-kappa-B-inhibitor alpha (NFKBIA) is a developmental marker of NF-\u03baB\/p65 activation during in vitro oocyte maturation and early embryogenesis. <em>Hum Reprod.<\/em> 2011 May;26(5):1191-201. doi: 10.1093\/humrep\/der040.<\/p><p>Laperuta C, Spizzichino L, D&#8217;Adamo P, Monfregola J, Maiorino A, D&#8217;Eustacchio A, Ventruto V, Neri G, D&#8217;Urso M, Chiurazzi P, Ursini MV, <strong>Miano MG.<\/strong> MRX87 family with Aristaless X dup24bp mutation and implication for polyAlanine expansions. <em>BMC Med Genet.<\/em> 2007 May 4;8:25. doi: 10.1186\/1471-2350-8-25.<\/p><p>Annunziata I, Lanzara C, Conte I, Zullo A, Ventruto V, Rinaldi MM, D&#8217;Urso M, Casari G, Ciccodicola A, <strong>Miano MG.<\/strong> Mapping of MRX81 in Xp11.2-Xq12 suggests the presence of a new gene involved in nonspecific X-linked mental retardation. <em>Am J Med Genet A.<\/em> 2003 Apr 30;118A(3):217-22. doi: 10.1002\/ajmg.a.10144.<\/p><p>Ciccodicola A, D&#8217;Esposito M, Esposito T, Gianfrancesco F, Migliaccio C, <strong>Miano MG<\/strong>, Matarazzo MR, Vacca M, Franz\u00e8 A, Cuccurese M, Cocchia M, Curci A, Terracciano A, Torino A, Cocchia S, Mercadante G, Pannone E, Archidiacono N, Rocchi M, Schlessinger D, D&#8217;Urso M. Differentially regulated and evolved genes in the fully sequenced Xq\/Yq pseudoautosomal region. <em>Hum Mol Genet.<\/em> 2000 Feb 12;9(3):395-401. doi: 10.1093\/hmg\/9.3.395.<\/p><p>Vervoort R, Lennon A, Bird AC, Tulloch B, Axton R, <strong>Miano MG,<\/strong> Meindl A, Meitinger T, Ciccodicola A, Wright AF. Mutational hot spot within a new RPGR exon in X-linked retinitis pigmentosa. <em>Nat Genet.<\/em> 2000 Aug;25(4):462-6. doi: 10.1038\/78182. PMID: 10932196<\/p><div id=\"drum-screenshare-extension\" style=\"display: none\">1.0.0.20<\/div><div id=\"drum-screenshare-extension\" style=\"display: none\">1.0.0.20<\/div><div id=\"drum-screenshare-extension\" style=\"display: none\">1.0.0.20<\/div>                    <\/div>\n\t\t        \n                    <div id=\"professional-experience-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"professional-experience-tab\">\n\t\t\t\t        <p><strong><u>Education<\/u><\/strong><\/p><p>PhD in Systematic Biology, Faculty of Biological Sciences, University of Naples Federico II, Naples, 2003.<\/p><p>Master of Science in Statistical Genetics, Faculty of Medicine, University of Pavia, European Schools for Advanced Studies in Molecular Medicine and Genetic Epidemiology, Pavia, 2000.<\/p><p>Specialist Degree summa cum laude in Medical Genetics, Faculty of Medicine at the University of Rome La Sapienza, Rome, 1997.<\/p><p>Degree summa cum laude in Biology, Faculty of Biological Sciences at the University of Naples Federico II, Naples, 1990.<\/p><p><strong><u>Research Experience<\/u><\/strong><\/p><p>CNR Senior Researcher at Institute of Genetics and Biophysics \u201cAdriano Buzzati Traverso\u201d, Naples, 2021 &#8211; Present.<\/p><p>CNR-Short Term Fellow visiting the University of Adelaide. Australia. 2013.<\/p><p>Group Leader in Human Molecular Neurogenetics, 2006 &#8211; Present.<\/p><p>CNR Researcher at Institute of Genetics and Biophysics \u201cAdriano Buzzati Traverso\u201d, Naples, 2001<\/p><p>International Institute of Genetics and Biophysics, Naples, Telethon and MIUR Fellowship, 1998 &#8211; 2000.<\/p><p>Medical Research Council Fellow visiting the Human Genetic Unit\u2212MRC, Edinburgh, UK.1999.<\/p><p>EMBO short-term Fellow visiting the Human Genetic Unit at Medical Research Council (MRC), Edinburgh, UK,1998.<\/p><p>International Institute of Genetics and Biophysics, Naples, CNR Fellowship, 1996.<\/p><p>National Cancer Institute, Naples, 1995. Fellowship.<\/p><p>University of Naples \u201cFederico II\u201d, Faculty of Medicine, Cytogenetic and Prenatal Diagnosis. Naples, 1992 -1994.<\/p><p>International Institute of Genetics and Biophysics-CNR, Naples, Post\u2212degree Training, 1991-1992.<\/p><div id=\"drum-screenshare-extension\" style=\"display: none\">1.0.0.20<\/div>                    <\/div>\n\t\t        \n                    <div id=\"research-group-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"research-group-tab\">\n\t\t\t\t        <p><div class=\"tmm tmm_research-group-miano\"><div class=\"tmm_2_columns tmm_wrap tmm_plugin_f\"><span class=\"tmm_two_containers_tablet\"><\/span><div class=\"tmm_container\"><div class=\"tmm_member\" style=\"border-top:#006293 solid 5px;\"><div class=\"tmm_photo tmm_pic_research-group-miano_0\" style=\"background: url(https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/01\/Drongitis_Denise.jpg); margin-left: auto; margin-right:auto; background-size:cover !important;\"><\/div><div class=\"tmm_textblock\"><div class=\"tmm_names\"><span class=\"tmm_fname\">Denise<\/span> <span class=\"tmm_lname\">Drongitis<\/span><\/div><div class=\"tmm_job\">Post-doc<\/div><div class=\"tmm_desc\" style=\"text-align:\"><p><strong><img decoding=\"async\" class=\"alignnone wp-image-2317\" src=\"http:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png\" alt=\"\" width=\"19\" height=\"19\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png 512w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-300x300.png 300w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-150x150.png 150w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-270x250.png 270w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-510x510.png 510w\" sizes=\"(max-width: 19px) 100vw, 19px\" \/><\/strong> denise.drongitis@igb.cnr.it<\/p><p><strong>Twitter:<\/strong> @DrongitisD<\/p><p><strong>Project Title:<\/strong> Neuroproteomics in <em>Arx <\/em>mice models and functional analysis of deregulated molecular pathways<\/p><\/div><div class=\"tmm_scblock\"><\/div><\/div><\/div><div class=\"tmm_member\" style=\"border-top:#006293 solid 5px;\"><div class=\"tmm_photo tmm_pic_research-group-miano_1\" style=\"background: url(https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/01\/Verrillo_Lucia.jpg); margin-left: auto; margin-right:auto; background-size:cover !important;\"><\/div><div class=\"tmm_textblock\"><div class=\"tmm_names\"><span class=\"tmm_fname\">Lucia<\/span> <span class=\"tmm_lname\">Verillo<\/span><\/div><div class=\"tmm_job\">Post-doc<\/div><div class=\"tmm_desc\" style=\"text-align:\"><p><strong><img decoding=\"async\" class=\"alignnone wp-image-2317\" src=\"http:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png\" alt=\"\" width=\"19\" height=\"19\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png 512w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-300x300.png 300w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-150x150.png 150w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-270x250.png 270w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-510x510.png 510w\" sizes=\"(max-width: 19px) 100vw, 19px\" \/><\/strong> lucia.verrillo@igb.cnr.it<\/p><p><strong>Twitter:<\/strong> @lucia_vrl<\/p><p><strong>Project Title:<\/strong> Identification of new therapeutical compounds for Infantile spams caused by polyalanine elongations in ARX<\/p><\/div><div class=\"tmm_scblock\"><\/div><\/div><\/div><span class=\"tmm_two_containers_tablet\"><\/span><\/div><span class=\"tmm_columns_containers_desktop\"><\/span><div class=\"tmm_container\"><div class=\"tmm_member\" style=\"border-top:#006293 solid 5px;\"><div class=\"tmm_photo tmm_pic_research-group-miano_2\" style=\"background: url(https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/01\/Lepre_Miriana.jpg); margin-left: auto; margin-right:auto; background-size:cover !important;\"><\/div><div class=\"tmm_textblock\"><div class=\"tmm_names\"><span class=\"tmm_fname\">Miriana<\/span> <span class=\"tmm_lname\">Lepre<\/span><\/div><div class=\"tmm_job\">Ungraduated student<\/div><div class=\"tmm_desc\" style=\"text-align:\"><p><strong><img decoding=\"async\" class=\"alignnone wp-image-2317\" src=\"http:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png\" alt=\"\" width=\"19\" height=\"19\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png 512w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-300x300.png 300w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-150x150.png 150w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-270x250.png 270w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-510x510.png 510w\" sizes=\"(max-width: 19px) 100vw, 19px\" \/><\/strong> miriana.lepre@igb.cnr.it<\/p><p><strong>Facebook:<\/strong> <a href=\"https:\/\/www.facebook.com\/miriana.lepre\">https:\/\/www.facebook.com\/miriana.lepre<\/a><\/p><p><strong>Project Title:<\/strong> Analysis of microtubule organization and synaptogenesis in <em>Arx<\/em>-polyalanine mice<\/p><p><strong>&nbsp;<\/strong><\/p><\/div><div class=\"tmm_scblock\"><\/div><\/div><\/div><div style=\"clear:both;\"><\/div><\/div><\/div><\/div><\/p><p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-12390\" src=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/01\/Miano_Group-1.jpg\" alt=\"\" width=\"1968\" height=\"1517\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/01\/Miano_Group-1.jpg 1968w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/01\/Miano_Group-1-300x231.jpg 300w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/01\/Miano_Group-1-1024x789.jpg 1024w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/01\/Miano_Group-1-768x592.jpg 768w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/01\/Miano_Group-1-1536x1184.jpg 1536w\" sizes=\"(max-width: 1968px) 100vw, 1968px\" \/><\/p>                    <\/div>\n\t\t                    <\/div>\n        <\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Maria Giuseppina Miano Senior Researcher +39 081 6132261-445 \u00a0 mariag.miano@igb.cnr.it Neurobiology and Brain Functioning\/Genetics, Genomics and Epigenetics of Diseases Keywords: Malformations of cortical development (MCDs), developmental epileptic encephalopathies (DEE), intellectual disability (ID) and autism spectrum disorders (ASD); ARX-KDM5C axis; animal models; omic-strategies; drug-discovery. \u00a0\u00a0\u00a0 \u00a0 Twitter:\u00a0 Personal &#8211; Lab 1.0.0.20 Research Interest Selected Publications Professional [&hellip;]<\/p>\n","protected":false},"author":75,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"class_list":["post-2452","page","type-page","status-publish","czr-hentry"],"_links":{"self":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages\/2452","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/users\/75"}],"replies":[{"embeddable":true,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/comments?post=2452"}],"version-history":[{"count":100,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages\/2452\/revisions"}],"predecessor-version":[{"id":15981,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages\/2452\/revisions\/15981"}],"wp:attachment":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/media?parent=2452"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}