{"id":2459,"date":"2021-03-02T13:06:44","date_gmt":"2021-03-02T12:06:44","guid":{"rendered":"https:\/\/www.igb.cnr.it\/?page_id=2459"},"modified":"2025-03-27T11:18:31","modified_gmt":"2025-03-27T10:18:31","slug":"antonella-prisco","status":"publish","type":"page","link":"https:\/\/www.igb.cnr.it\/index.php\/antonella-prisco\/","title":{"rendered":"Antonella Prisco"},"content":{"rendered":"\t\t
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\n\t\t\t\t\t\t\t\"DSC_0176\"\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t<\/div>\n\n\t\t\t\n\t\t\t
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Antonella Prisco<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Senior Researcher<\/span><\/strong><\/h3>

\"\" +39 081 6132316-446 \u00a0 \u00a0\"\" antonella.prisco@igb.cnr.it<\/strong><\/p>

Organogenesys and Tissue Differentiation<\/strong><\/p><\/div><\/div>

Keywords: <\/strong>Immune response, Immunological memory, Antibody, Lymphocytes, Vaccine, In silico<\/em> modeling, Polymer Models of Chromatin<\/p><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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  • \n \n \n \n Research Interest<\/span> <\/li>\n
  • \n \n \n \n Selected Publications<\/span> <\/li>\n
  • \n \n \n \n Professional Experience<\/span> <\/li>\n
  • \n \n \n \n Research Group<\/span> <\/li>\n <\/ul>\n <\/div>\n \n
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    The main current topic of my research is the identification of correlates of the magnitude and duration of immunological memory, with a special focus on inter-individual differences. My approach involves mouse experiments, the analysis of human clinical data, and computational simulations. My group developed prototype vaccines consisting of an immunodominant B cell epitope, displayed either on a multimeric protein, or on the capside of a filamentous bacteriophage.\u00a0 We analyzed of the effect of the dosing protocol, in silico and in mouse experiments, and\u00a0 we contributed to the understanding of the time scale of development of immunological memory, and the effect of the interval between doses on vaccination.<\/p>

    In collaboration with physicist Mario Nicodemi, I\u00a0 developed the strings and binders model of the three-dimensional architecture of the mammalian genome, and statistical mechanics models of regulatory genetic mechanisms (choice in X inactivation, pairing of homologous chromosomes at meiosis)\u00a0 which have been investigated by computer simulations and checked against experimental data.<\/p> <\/div>\n\t\t \n

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    -Vaccination with (1\u201311) E2 in alum efficiently induces an antibody response to \u03b2-amyloid without affecting brain \u03b2-amyloid load and microglia activation in 3xTg mice<\/p>

    F Mantile, A Capasso, N Villacampa, M Donnini, GL Liguori, G Constantin, P De Berardinis, MT Heneka, A Prisco<\/p>

    Aging Clinical and Experimental Research\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 2021<\/p>

    \u00a0<\/p>

    – Comparison of the Hi-C, GAM and SPRITE methods using polymer models of chromatin<\/p>

    L Fiorillo, et al.<\/p>

    Nature methods\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 2021<\/p>

    \u00a0<\/p>

    – Vaccination against \u03b2-Amyloid as a Strategy for the Prevention of Alzheimer\u2019s Disease<\/p>

    F Mantile, A Prisco<\/p>

    Biology \u00a02020<\/p>

    \u00a0<\/p>

    – A dynamic folded hairpin conformation is associated with \u03b1-globin activation in erythroid cells<\/p>

    AM Chiariello, et al.<\/p>

    Cell Reports\u00a0 2020<\/p>

    \u00a0<\/p>

    – Modeling single-molecule conformations of the HoxD region in mouse embryonic stem and cortical neuronal cells<\/p>

    S Bianco, et al.<\/p>

    Cell Reports\u00a0 2019<\/p>

    \u00a0<\/p>

    – Identification of a consolidation phase in immunological memory<\/p>

    F Mantile, A Capasso, P De Berardinis, A Prisco<\/p>

    Frontiers in Immunology\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 2019<\/p>

    \u00a0<\/p>

    – Structure of the human chromosome interaction network<\/p>

    S Sarnataro, AM Chiariello, A Esposito, A Prisco, M Nicodemi<\/p>

    PLoS One \u00a0\u00a0\u00a0 2017<\/p>

    \u00a0<\/p>

    – Alum and Squalene-Oil-in-Water Emulsion Enhance the Titer and Avidity of Anti-A\u03b2 Antibodies Induced by Multimeric Protein Antigen (1\u201311) E2, Preserving the Igg1-Skewed Isotype \u2026<\/p>

    F Mantile, M Trovato, A Santoni, P Barba, S Ottonello, P De Berardinis, A Prisco<\/p>

    PLoS One \u00a0\u00a0\u00a0 2014<\/p>



    – How the interval between prime and boost injection affects the immune response in a computational model of the immune system<\/p>

    F Castiglione, F Mantile, P De Berardinis, A Prisco<\/p>

    Computational and mathematical methods in medicine \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 2012<\/p>

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    – Thermodynamic pathways to genome spatial organization in the cell nucleus<\/p>

    M Nicodemi, A Prisco<\/p>

    Biophysical journal\u00a0\u00a0\u00a0\u00a0\u00a0 2009<\/p>

    \u00a0<\/p>

    – A thermodynamic switch for chromosome colocalization<\/p>

    M Nicodemi, B Panning, A Prisco<\/p>

    Genetics\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 2008<\/p>

    \u00a0<\/p>

    – Self-assembly and DNA binding of the blocking factor in X chromosome inactivation<\/p>

    M Nicodemi, A Prisco<\/p>

    PLoS computational biology \u00a0\u00a0\u00a0\u00a0 2007<\/p>

    \u00a0<\/p>

    – Symmetry-breaking model for X-chromosome inactivation<\/p>

    M Nicodemi, A Prisco<\/p>

    Physical review letters 2007<\/p>

    \u00a0<\/p>

    – Lineage-specific requirement for the PH domain of Vav1 in the activation of CD4+ but not CD8+ T cells<\/p>

    A Prisco, L Vanes, S Ruf, C Trigueros, VLJ Tybulewicz<\/p>

    Immunity \u00a0\u00a0\u00a0\u00a0 2005<\/p>

    \u00a0<\/p>

    – The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-\u03baB pathways<\/p>

    PS Costello et al.<\/p>

    Proceedings of the National Academy of Sciences 1999<\/p>

    \u00a0<\/p> <\/div>\n\t\t \n

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    Researcher at IGB since 2001.\u00a0 Previously, Research Associate at Medical Research Council, London.<\/p>

    Coordinator, and PI of a Research Unit, of ADVACCINE Pre-clinical testing of Alzheimer’s Disease vaccine (1-11)E2, supported by the Aging project of CNR.\u00a0<\/p>

    Teaching activities at Universit\u00e0 Vanvitelli since 2014. Adjunct Professor of Molecular biotechnology, since 2018.<\/p>

    Editorial roles for Frontiers in Immunology, Biology MPDI, PeerJ.<\/p>

    Grant Reviewer for Ministero dell’Universit\u00e0 e della Ricerca , Ministero della Salute, University of Pavia, Agence Nationale de la Recherche.<\/p>

    Chair of\u00a0 several Science and Society events at CNR, including The Science Caf\u00e8\u00a0 and DNA in suono.<\/p>

    Member of SIICA and CNR Immunology Network (CIN).<\/p> <\/div>\n\t\t \n

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    <\/div><\/div><\/div><\/p> <\/div>\n\t\t <\/div>\n <\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

    Antonella Prisco Senior Researcher +39 081 6132316-446 \u00a0 \u00a0 antonella.prisco@igb.cnr.it Organogenesys and Tissue Differentiation Keywords: Immune response, Immunological memory, Antibody, Lymphocytes, Vaccine, In silico modeling, Polymer Models of Chromatin Research Interest Selected Publications Professional Experience Research Group The main current topic of my research is the identification of correlates of the magnitude and duration of […]<\/p>\n","protected":false},"author":59,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"class_list":["post-2459","page","type-page","status-publish","czr-hentry"],"_links":{"self":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages\/2459","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/users\/59"}],"replies":[{"embeddable":true,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/comments?post=2459"}],"version-history":[{"count":28,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages\/2459\/revisions"}],"predecessor-version":[{"id":18255,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages\/2459\/revisions\/18255"}],"wp:attachment":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/media?parent=2459"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}