{"id":2462,"date":"2021-03-02T13:07:06","date_gmt":"2021-03-02T12:07:06","guid":{"rendered":"https:\/\/www.igb.cnr.it\/?page_id=2462"},"modified":"2026-05-06T13:49:51","modified_gmt":"2026-05-06T11:49:51","slug":"alfredo-ciccodicola","status":"publish","type":"page","link":"https:\/\/www.igb.cnr.it\/index.php\/alfredo-ciccodicola\/","title":{"rendered":"Alfredo Ciccodicola"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2462\" class=\"elementor elementor-2462\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-29128a0d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"29128a0d\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-76f0535\" data-id=\"76f0535\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9508ce6 elementor-widget elementor-widget-bdt-member\" data-id=\"9508ce6\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;none&quot;}\" data-widget_type=\"bdt-member.bdt-phaedra\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"bdt-member skin-phaedra bdt-transition-toggle\">\n\t\t\t\n\t\t\t\t<div class=\"bdt-member-photo-wrapper\">\n\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"bdt-member-photo\">\n\t\t\t\t\t\t<div class=\"\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/10\/DSC_0382.jpg\" title=\"DSC_0382\" alt=\"DSC_0382\" loading=\"lazy\" \/>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t<\/div>\n\n\t\t\t\n\t\t\t<div class=\"bdt-member-overlay bdt-overlay-default bdt-position-cover bdt-transition-fade bdt-position-z-index\">\n\t\t\t\t<div class=\"bdt-member-desc bdt-position-center bdt-text-center\">\n\t\t\t\t\t<div class=\"bdt-member-content bdt-transition-slide-top-small\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-640f9836\" data-id=\"640f9836\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6c8223a0 elementor-widget elementor-widget-heading\" data-id=\"6c8223a0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Alfredo Ciccodicola<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-11fad301 elementor-widget elementor-widget-spacer\" data-id=\"11fad301\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bea71bc elementor-widget elementor-widget-text-editor\" data-id=\"bea71bc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3><strong><span style=\"color: #006293;\">Acting Director<\/span><\/strong><\/h3><div><p><img decoding=\"async\" class=\"alignnone wp-image-2318\" src=\"http:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona.png\" alt=\"\" width=\"17\" height=\"17\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona.png 512w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-300x300.png 300w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-150x150.png 150w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-270x250.png 270w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-510x510.png 510w\" sizes=\"(max-width: 17px) 100vw, 17px\" \/><strong>+39 081 6132259\u00a0 \u00a0<img decoding=\"async\" class=\"alignnone wp-image-2317\" src=\"http:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png\" alt=\"\" width=\"19\" height=\"19\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png 512w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-300x300.png 300w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-150x150.png 150w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-270x250.png 270w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-510x510.png 510w\" sizes=\"(max-width: 19px) 100vw, 19px\" \/> alfredo.ciccodicola@igb.cnr.it<\/strong><\/p><p class=\"elementor-heading-title elementor-size-default\"><strong>Genetics, Genomics and Epigenetics of Diseases<\/strong><\/p><p><strong>Keywords: <\/strong>Human diseases, Diabetic Retinopathy, Next Generation Sequencing, transcriptional regulation, epigenetic regulation, alternative splicing, computational analysis.<\/p><\/div><div class=\"notranslate\" style=\"all: initial;\">\u00a0<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-18b921cb elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"18b921cb\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7acddfd8\" data-id=\"7acddfd8\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-58636fa2 elementor-widget elementor-widget-eael-adv-tabs\" data-id=\"58636fa2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"eael-adv-tabs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t        <div data-scroll-on-click=\"no\" data-scroll-speed=\"300\" id=\"eael-advance-tabs-58636fa2\" class=\"eael-advance-tabs eael-tabs-horizontal eael-tab-auto-active \" data-tabid=\"58636fa2\">\n            <div class=\"eael-tabs-nav\">\n                <ul class=\"\" role=\"tablist\">\n                                            <li id=\"research-interest\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"research-interest-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >Research Interest<\/span>                                                    <\/li>\n                                            <li id=\"selected-publications\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"selected-publications-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >Selected Publications<\/span>                                                    <\/li>\n                                            <li id=\"professional-experience\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"false\" data-tab=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"professional-experience-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >Professional Experience<\/span>                                                    <\/li>\n                                            <li id=\"research-group\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"false\" data-tab=\"4\" role=\"tab\" tabindex=\"-1\" aria-controls=\"research-group-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >Research Group<\/span>                                                    <\/li>\n                                    <\/ul>\n            <\/div>\n            \n            <div class=\"eael-tabs-content\">\n\t\t        \n                    <div id=\"research-interest-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"research-interest-tab\">\n\t\t\t\t        <p>The scientific interests of my research group are mainly aimed at studying the molecular mechanisms underlying complex human diseases such as: diabetes, obesity and cancer using &#8220;omic&#8221; approaches including the analysis of Next Generation Sequencing (NGS) data.<\/p><p>Furthermore, the studies are also aimed at understanding transcriptional regulation, epigenetic regulation and alternative splicing and their deregulation in human diseases.<\/p><p>A particular interest in recent years has been directed to the study of the molecular mechanisms underlying Diabetic Retinopathy (DR). Diabetic retinopathy is the main cause of blindness that arises with the aging of the retinal function in diabetic patients. Chronic hyperglycemia, to which the retinal endothelial cells of diabetic individuals are exposed, represents the main etiological factor of non-genetic blindness in old age. Our studies intend to understand, both from a molecular and phenotypic \/ functional point of view, what is the role of methylglyoxal (MG) &#8211; the main precursor of advanced glycation products &#8211; in damage to the retinal endothelium. In fact, MG mediates the pathological effects induced by hyperglycemia and determines oxidative stress, one of the main factors associated with aging and the onset of retinopathy. To this end, experiments are underway to verify the functional damage induced by MG in human retinal endothelial cells by means of functional assays, NGS and computational analysis.<\/p><p>\u00a0<\/p><p><strong><span style=\"color: #800000;\">PERSONAL INFORMATION<\/span><\/strong><\/p><p><strong><span style=\"color: #000000;\">Contact:<\/span> <\/strong>CNR, Institute of Genetics and Biophysics &#8220;Adriano Buzzati Traverso&#8221;, Via P. Castellino, 111 &#8211; 80131 Naples<\/p><p>Department of Science and Technology, University of Naples &#8220;Parthenope&#8221;, Centro Direzionale, Isola C4 &#8211; Naples;<\/p><p><strong>Phone:<\/strong> +390815476551;<\/p><p><strong>e-mail:<\/strong> alfredo.ciccodicola@uniparthenope.it<\/p>                    <\/div>\n\t\t        \n                    <div id=\"selected-publications-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"selected-publications-tab\">\n\t\t\t\t        <ul><li>Cataldi S, Aprile M, Melillo D, Mucel I, Giorgetti-Peraldi S, Cormont M, Italiani P, Bl\u00fcher M, Tanti JF, Ciccodicola A, Costa V. TNF\u03b1 Mediates Inflammation-Induced Effects on PPARG Splicing in Adipose Tissue and Mesenchymal Precursor Cells. Cells. 2021 Dec 24;11(1):42. doi: 10.3390\/cells11010042.<\/li><li>Cataldi S, Costa V, Ciccodicola A, Aprile M. PPAR\u03b3 and Diabetes: Beyond the Genome and Towards Personalized Medicine. Curr Diab Rep. 2021 Apr 18;21(6):18. doi: 10.1007\/s11892-021-01385-5.<\/li><li>Aprile M, Cataldi S, Perfetto C, Ambrosio MR, Italiani P, Tat\u00e8 R, Bl\u00fcher M, Ciccodicola A, Costa V. In-Vitro-Generated Hypertrophic-Like Adipocytes Displaying PPARG Isoforms Unbalance Recapitulate Adipocyte Dysfunctions In Vivo. Cells. 2020 May 21;9(5):1284. doi: 10.3390\/cells9051284.<\/li><li>Casamassimi A, Ciccodicola A. Transcriptional Regulation: Molecules, Involved Mechanisms, and Misregulation. Int J Mol Sci. 2019 Mar 14;20(6):1281. doi: 10.3390\/ijms20061281.<\/li><li>Esposito R, Esposito D, Pallante P, Fusco A, Ciccodicola A, Costa V. Oncogenic Properties of the Antisense lncRNA COMET in BRAF- and RET-Driven Papillary Thyroid Carcinomas. Cancer Res. 2019 May 1;79(9):2124-2135. doi: 10.1158\/0008-5472.CAN-18-2520.<\/li><li>Aprile M, Cataldi S, Ambrosio MR, D&#8217;Esposito V, Lim K, Dietrich A, Bl\u00fcher M, Savage DB, Formisano P, Ciccodicola A, Costa V. PPAR\u03b3\u03945, a Naturally Occurring Dominant-Negative Splice Isoform, Impairs PPAR\u03b3 Function and Adipocyte Differentiation. Cell Rep. 2018 Nov 6;25(6):1577-1592.e6. doi: 10.1016\/j.celrep.2018.10.035.<\/li><li>Sorrentino A, Federico A, Rienzo M, Gazzerro P, Bifulco M, Ciccodicola A, Casamassimi A, Abbondanza C. PR\/SET Domain Family and Cancer: Novel Insights from the Cancer Genome Atlas. Int J Mol Sci. 2018 Oct 19;19(10):3250. doi: 10.3390\/ijms19103250.<\/li><li>Li J, Deng SP, Vieira J, Thomas J, Costa V, Tseng CS, Ivankovic F, Ciccodicola A, Yu P. RBPMetaDB: a comprehensive annotation of mouse RNA-Seq datasets with perturbations of RNA-binding proteins. Database (Oxford). 2018 Jan 1;2018:bay054. doi: 10.1093\/database\/bay054.<\/li><li>Sorrentino A, Rienzo M, Ciccodicola A, Casamassimi A, Abbondanza C. Human PRDM2: Structure, function and pathophysiology. Biochim Biophys Acta Gene Regul Mech. 2018 Jun 6:S1874-9399(18)30071-3. doi: 10.1016\/j.bbagrm.2018.06.002.<\/li><li>Ambrosio MR, D&#8217;Esposito V, Costa V, Liguoro D, Collina F, Cantile M, Prevete N, Passaro C, Mosca G, De Laurentiis M, Di Bonito M, Botti G, Franco R, Beguinot F, Ciccodicola A, Formisano P. Glucose impairs tamoxifen responsiveness modulating connective tissue growth factor in breast cancer cells. 2017 Nov 20;8(65):109000-109017. doi: 10.18632\/oncotarget.22552.<\/li><li>Li J, Tseng CS, Federico A, Ivankovic F, Huang YS, Ciccodicola A, Swanson MS, Yu P. SFMetaDB: a comprehensive annotation of mouse RNA splicing factor RNA-Seq datasets. Database (Oxford). 2017 Jan 1;2017:bax071. doi: 10.1093\/database\/bax071.<\/li><li>Casamassimi A, Federico A, Rienzo M, Esposito S, Ciccodicola A. Transcriptome Profiling in Human Diseases: New Advances and Perspectives. Int J Mol Sci. 2017 Jul 29;18(8):1652. doi: 10.3390\/ijms18081652.<\/li><li>Schiano C, Costa V, Aprile M, Grimaldi V, Maiello C, Esposito R, Soricelli A, Colantuoni V, Donatelli F, Ciccodicola A, Napoli C. Heart failure: Pilot transcriptomic analysis of cardiac tissue by RNA-sequencing. Cardiol J. 2017;24(5):539-553. doi: 10.5603\/CJ.a2017.0052.<\/li><li>Federico A, Rienzo M, Abbondanza C, Costa V, Ciccodicola A, Casamassimi A. Pan-Cancer Mutational and Transcriptional Analysis of the Integrator Complex. Int J Mol Sci. 2017 Apr 29;18(5):936. doi: 10.3390\/ijms18050936.<\/li><li>Trovato M, Maurano F, D&#8217;Apice L, Costa V, Sartorius R, Cuccaro F, McBurney SP, Krebs SJ, Prisco A, Ciccodicola A, Rossi M, Haigwood NL, De Berardinis P. E2 multimeric scaffold for vaccine formulation: immune response by intranasal delivery and transcriptome profile of E2-pulsed dendritic cells. BMC Microbiol. 2016 Jul 16;16(1):152. doi: 10.1186\/s12866-016-0772-x.<\/li><li>Costa V, Federico A, Pollastro C, Ziviello C, Cataldi S, Formisano P, Ciccodicola A. Computational Analysis of Single Nucleotide Polymorphisms Associated with Altered Drug Responsiveness in Type 2 Diabetes. Int J Mol Sci. 2016 Jun 25;17(7):1008. doi: 10.3390\/ijms17071008.<\/li><li>Parrillo L, Costa V, Raciti GA, Longo M, Spinelli R, Esposito R, Nigro C, Vastolo V, Desiderio A, Zatterale F, Ciccodicola A, Formisano P, Miele C, Beguinot F. Hoxa5 undergoes dynamic DNA methylation and transcriptional repression in the adipose tissue of mice exposed to high-fat diet. Int J Obes (Lond). 2016 Jun;40(6):929-37. doi: 10.1038\/ijo.2016.36.<\/li><li>Aversa R, Sorrentino A, Esposito R, Ambrosio MR, Amato A, Zambelli A, Ciccodicola A, D&#8217;Apice L, Costa V. Alternative Splicing in Adhesion- and Motility-Related Genes in Breast Cancer. Int J Mol Sci. 2016 Jan 16;17(1):121. doi: 10.3390\/ijms17010121.<\/li><li>Pollastro C, Ziviello C, Costa V, Ciccodicola A. Pharmacogenomics of Drug Response in Type 2 Diabetes: Toward the Definition of Tailored Therapies? PPAR Res. 2015;2015:415149. doi: 10.1155\/2015\/415149.<\/li><li>Costa V, Esposito R, Pallante P, Ciccodicola A, Fusco A. The &#8220;next-generation&#8221; knowledge of papillary thyroid carcinoma. Cell Cycle. 2015;14(13):2018-21. doi: 10.1080\/15384101.2015.1049786.<\/li><li>Sartorius R, D&#8217;Apice L, Trovato M, Cuccaro F, Costa V, De Leo MG, Marzullo VM, Biondo C, D&#8217;Auria S, De Matteis MA, Ciccodicola A, De Berardinis P. Antigen delivery by filamentous bacteriophage fd displaying an anti-DEC-205 single-chain variable fragment confers adjuvanticity by triggering a TLR9-mediated immune response. EMBO Mol Med. 2015 Apr 17;7(7):973-88. doi: 10.15252\/emmm.201404525.<\/li><li>Costa V, Esposito R, Ziviello C, Sepe R, Bim LV, Cacciola NA, Decaussin-Petrucci M, Pallante P, Fusco A, Ciccodicola A. New somatic mutations and WNK1-B4GALNT3 gene fusion in papillary thyroid carcinoma. Oncotarget. 2015 May 10;6(13):11242-51. doi: 10.18632\/oncotarget.3593.<\/li><li>Scarpato M, Federico A, Ciccodicola A, Costa V. Novel transcription factor variants through RNA-sequencing: the importance of being &#8220;alternative&#8221;. Int J Mol Sci. 2015 Jan 13;16(1):1755-71. doi: 10.3390\/ijms16011755.<\/li><li>Rienzo M, Costa V, Scarpato M, Schiano C, Casamassimi A, Grimaldi V, Ciccodicola A, Napoli C. RNA-Seq for the identification of novel Mediator transcripts in endothelial progenitor cells. Gene. 2014 Aug 15;547(1):98-105. doi: 10.1016\/j.gene.2014.06.034.<\/li><li>Aprile M, Ambrosio MR, D&#8217;Esposito V, Beguinot F, Formisano P, Costa V, Ciccodicola A. PPARG in Human Adipogenesis: Differential Contribution of Canonical Transcripts and Dominant Negative Isoforms. PPAR Res. 2014;2014:537865. doi: 10.1155\/2014\/537865.<\/li><li>Scarpato M, Esposito R, Evangelista D, Aprile M, Ambrosio MR, Angelini C, Ciccodicola A, Costa V. AnaLysis of Expression on human chromosome 21, ALE-HSA21: a pilot integrated web resource. Database (Oxford). 2014 Feb 25;2014:bau009. doi: 10.1093\/database\/bau009.<\/li><li>D&#8217;Apice L, Costa V, Valente C, Trovato M, Pagani A, Manera S, Regolo L, Zambelli A, Ciccodicola A, De Berardinis P. Analysis of SEMA6B gene expression in breast cancer: identification of a new isoform. Biochim Biophys Acta. 2013 Oct;1830(10):4543-53. doi: 10.1016\/j.bbagen.2013.05.003.<\/li><li>Costa V, Esposito R, Aprile M, Ciccodicola A. Non-coding RNA and pseudogenes in neurodegenerative diseases: &#8220;The (un)Usual Suspects&#8221;. Front Genet. 2012 Oct 31;3:231. doi: 10.3389\/fgene.2012.00231.<\/li><li>Costa V, Aprile M, Esposito R, Ciccodicola A. RNA-Seq and human complex diseases: recent accomplishments and future perspectives. Eur J Hum Genet. 2013 Feb;21(2):134-42. doi: 10.1038\/ejhg.2012.129.<\/li><\/ul>                    <\/div>\n\t\t        \n                    <div id=\"professional-experience-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"professional-experience-tab\">\n\t\t\t\t        <p><strong><span style=\"color: #800000;\">EXPERIENCE AND POSITIONS<\/span><\/strong><\/p><p>2020 to present: Component of GEV05 &#8211; BIO\/18 &#8211; ANVUR VQR 2015\/2019<\/p><p>2016\/2020: Component of IGB Advisory Committee<\/p><p>2014: Award of the National Scientific Qualification (Abilitazione Scientifica Nazionale) as Full Professor in General Pathology and Clinical Pathology (06\/A2)<\/p><p>2011\/2013: Component of GEV05 &#8211; BIO\/18 &#8211; ANVUR VQR 2004\/2010<\/p><p>2011\/2012 to present: Professor of Molecular Biology, University of Naples &#8220;Parthenope&#8221;<\/p><p>2011\/2012 to present: Member of the Doctorate Board &#8220;Environment, Resources and Sustainable Development&#8221;, University of Naples &#8220;Parthenope&#8221;<\/p><p>2010\/2011 to 2018\/2019: Professor of Genetics, University of Naples &#8220;Parthenope&#8221;<\/p><p>2010 to present: CNR Researcher Director, Institute of Genetics and Biophysics &#8220;Adriano Buzzati-Traverso&#8221;, Naples<\/p><p>2009-2015: Teaching Assistant in Genetics, University of Naples &#8220;Federico II&#8221;<\/p><p>2007-2009: Professor of Genetics, University of Naples &#8220;Parthenope&#8221;<\/p><p>2006-2014: Head of Commessa CNR, Department of Life Sciences (since 2012 Biomedicine Department)<\/p><p>2001 to 2010: CNR Senior Researcher, Institute of Genetics and Biophysics &#8220;Adriano Buzzati-Traverso&#8221;, Naples<\/p><p>2001 to present: Head of the Laboratory of Human Genetic Diseases at IGB-CNR<\/p><p>1999-2004: Head of Infrastructure Activity &#8220;DNA Sequencing Service&#8221; at IGB-CNR<\/p><p>1996-2001: CNR Researcher at the International Institute of Genetics and Biophysics, Naples<\/p><p>1992-1993: Visiting Scientist at Applied Biosystems Inc., Foster City, Ca., USA<\/p><p>1991: Visiting Scientist Specialist at Genentech Inc., South San Francisco, Ca., USA<\/p><p>1989: Research Associate at the School of Medicine, Washington University, St. Louis, Mo., USA<\/p><p>1987: Visiting Scientist at the Human Genetic Branch of NICHHDD, NIH, Bethesda, Md., USA<\/p><p>\u00a0<\/p><p><span style=\"color: #800000;\"><strong>EDUCATION AND TRAINING<\/strong><\/span><\/p><p>1993-1993: AIRC annual foreign fellowship<\/p><p>1991-1992: CNR Project &#8220;Genetic Engineering&#8221; annual fellowship<\/p><p>1989-1990: CNR Strategic Project &#8220;Mapping and sequencing the human genome&#8221; annual fellowships<\/p><p>1988-1989: CNR Strategic Project &#8220;Mapping and sequencing the human genome&#8221; annual fellowship.<\/p><p>July 1987: Degree in Biological Sciences with 110\/110 cum laude, from the University &#8220;Federico II&#8221; of Naples<\/p><p>1981: High school diploma (classical studies)<\/p><p>\u00a0<\/p><p><span style=\"color: #800000;\"><strong>AWARDS<\/strong><\/span><\/p><p>2019: \u201cPaul Harris Fellow\u201d of Rotary International (September 2021; July 2021; 2019; 2018; 2017)<\/p><p>1989: Gold Medal of the City of Naples, for the achievements on the human genome project<\/p><p>\u00a0<\/p><p><strong><span style=\"color: #800000;\">NATIONAL AND INTERNATIONAL GRANTED PROJECTS<\/span><\/strong><\/p><p>1996-1999: CEE BMH4-CT-961134: Sequence analysis of human Xq28<\/p><p>1997-1999: TELETHON_E546: X-linked retinitis pigmentosa (RP3): Screening for new mutations and promoter analysis of RPGR gene<\/p><p>1997-1999: CEE BMH4-CT-960338: Construction of an integrated transcriptional map of the human X Chromosome<\/p><p>1999: LR.31\/12\/94 Campania: Diagnosi molecolare di malattie genetiche associate al cromosoma X ed identificazione di nuove malattie genetiche<\/p><p>1999-2001: TELETHON_E1093: X-linked retinitis pigmentosa (RP3): Screening for new mutations and promoter analysis of RPGR gene<\/p><p>2000-2003: TELETHON-TIGEM_04: Systematic identification and charcterization of eye-expressed transcripts: novel candidate genes for eye diseases<\/p><p>2000-2003: TELETHON-TIGEM _9: TIGEM-IGB Sequencing core<\/p><p>2000-2003: MIUR-BIOGEM: Genetica molecolare di patologie associate ai cromosomi sessuali<\/p><p>2001-2004: MURST-CNR Legge 488\/92: Study of homologs of mammalian genes in C. elegans and D. melanogaster<\/p><p>2003-2006: POR2000\/2006 Campania: GEAR<\/p><p>2003-2004: Ricerca Finalizzata Ministero Salute FSN: Analisi mutazionale e trascrizionale del gene PPARG nella diagnostica precoce e nel trattamento dei tumori del colon-retto<\/p><p>2005: Legge 5\/2002 Campania: Analisi di nuovi polimorfismi del recettore nucleare PPAR-gamma in soggetti obesi<\/p><p>2012-2014: COST Action BM1006: Next Generation Sequencing Data Analysis Network<\/p><p>2012-2014: INTEROMICS PB05: Approcci omici per l\u2019identificazione di target molecolari nel processo dell\u2019angiogenesi mediante analisi di popolazioni e utilizzo di piattaforme di NGS<\/p><p>2012-2015: MIUR-PON01_02460: DIAGEN-SC<\/p><p>2013-2015: PO FESR 2007\/2013 Campania: TIMING<\/p><p>2014-2016 AIRC IG2013-14689: RNA-Seq for the identification of new biomarkers in papillary thyroid carcinoma progression: a pilot study<\/p><p>2017: II\u00b0INTEROMICS: ASPIRE<\/p><p>2019-2021: EFSD\/Boehringer Ingelheim European Research Programme: Molecular and functional effects of methylglyoxal on human microvascular retinal cells<\/p><p>\u00a0<\/p><p>Alfredo Ciccodicola is author of 111 papers published on international journals &#8220;peer reviewed&#8221;. Total citations: 8228 and H-index: 43 (to January 2022 source: Google Scholar); Scopus: Total citations: 5690, H-index: 37; ISI-Web: Total citations: 5383, H-index: 36.<\/p>                    <\/div>\n\t\t        \n                    <div id=\"research-group-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"research-group-tab\">\n\t\t\t\t        <div class=\"tmm tmm_research-group-ciccodicola\"><div class=\"tmm_2_columns tmm_wrap tmm_plugin_f\"><span class=\"tmm_two_containers_tablet\"><\/span><div class=\"tmm_container\"><div class=\"tmm_member\" style=\"border-top:#006293 solid 5px;\"><a target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.igb.cnr.it\/index.php\/valerio-costa\/\" title=\"Valerio Costa\"><div class=\"tmm_photo tmm_pic_research-group-ciccodicola_0\" style=\"background: url(https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/10\/DSC_0434.jpg); margin-left: auto; margin-right:auto; background-size:cover !important;\"><\/div><\/a><div class=\"tmm_textblock\"><div class=\"tmm_names\"><span class=\"tmm_fname\">Valerio<\/span> <span class=\"tmm_lname\">Costa<\/span><\/div><div class=\"tmm_job\">Senior Researcher<\/div><div class=\"tmm_desc\" style=\"text-align:\"><p><strong>Tel:<\/strong> +39081-6132617 \u00a0 \u00a0<\/p><p><strong>e-mail:<\/strong> <a href=\"mailto:valerio.costa@igb.cnr.it\">valerio.costa@igb.cnr.it\u00a0\u00a0<\/a><\/p><p><strong> Genetics, Genomics and Epigenetics of Diseases &#8211; Molecular Oncology<\/strong><\/p><p><strong>Keywords:<\/strong> Molecular Oncology; metabolism; obesity; computational biology<\/p><\/div><div class=\"tmm_scblock\"><\/div><\/div><\/div><div class=\"tmm_member\" style=\"border-top:#006293 solid 5px;\"><a target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.igb.cnr.it\/index.php\/marianna-aprile\/\" title=\"Marianna Aprile\"><div class=\"tmm_photo tmm_pic_research-group-ciccodicola_1\" style=\"background: url(https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/01\/DSC_0393.jpg); margin-left: auto; margin-right:auto; background-size:cover !important;\"><\/div><\/a><div class=\"tmm_textblock\"><div class=\"tmm_names\"><span class=\"tmm_fname\">Marianna<\/span> <span class=\"tmm_lname\">Aprile<\/span><\/div><div class=\"tmm_job\">CNR Researcher (AIRC funded)<\/div><div class=\"tmm_desc\" style=\"text-align:\"><p><strong>e-mail:<\/strong> <a href=\"mailto:marianna.aprile@igb.cnr.it\">marianna.aprile@igb.cnr.it<\/a><\/p><p><strong>Genetics, Genomics and Epigenetics of Diseases<\/strong><\/p><p><strong>Project Title:<\/strong> Assessing COMET Silencing as new Therapeutic Option in Braf-Mutated Thyroid Carcinomas<\/p><\/div><div class=\"tmm_scblock\"><\/div><\/div><\/div><span class=\"tmm_two_containers_tablet\"><\/span><\/div><span class=\"tmm_columns_containers_desktop\"><\/span><div class=\"tmm_container\"><div class=\"tmm_member\" style=\"border-top:#006293 solid 5px;\"><div class=\"tmm_photo tmm_pic_research-group-ciccodicola_2\" style=\"background: url(https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/12\/DSC_0386.jpg); margin-left: auto; margin-right:auto; background-size:cover !important;\"><\/div><div class=\"tmm_textblock\"><div class=\"tmm_names\"><span class=\"tmm_fname\">Mariagiovanna<\/span> <span class=\"tmm_lname\">Tramontano<\/span><\/div><div class=\"tmm_job\">PhD student in Traslational Medicine (Unicampania \u201cL.Vanvitelli\u201d)<\/div><div class=\"tmm_desc\" style=\"text-align:\"><p><strong>Tel:<\/strong> +39081-6132259 \u00a0<\/p><p><strong>e-mail:<\/strong> <a href=\"mailto:mariagiovanna.tramontano@igb.cnr.it\">mariagiovanna.tramontano@igb.cnr.it<\/a><\/p><p><strong>Project Title:<\/strong> Development of biomarkers using innovative computational analysis approaches for the diagnosis and treatment of diabetes complications<\/p><\/div><div class=\"tmm_scblock\"><\/div><\/div><\/div><div class=\"tmm_member\" style=\"border-top:#006293 solid 5px;\"><div class=\"tmm_photo tmm_pic_research-group-ciccodicola_3\" style=\"background: url(https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/01\/DSC_0391.jpg); margin-left: auto; margin-right:auto; background-size:cover !important;\"><\/div><div class=\"tmm_textblock\"><div class=\"tmm_names\"><span class=\"tmm_fname\">Caterina<\/span> <span class=\"tmm_lname\">Perfetto<\/span><\/div><div class=\"tmm_job\">Phd Student<\/div><div class=\"tmm_desc\" style=\"text-align:\"><p><strong>e-mail:<\/strong> <a href=\"mailto:caterina.perfetto@igb.cnr.it\">caterina.perfetto@igb.cnr.it<\/a><\/p><p><strong>Project Title:<\/strong> Studio dell&#8217;adattamento metabolico in cellule di carcinoma tiroideo indotte da mutazioni del gene BRAF<\/p><\/div><div class=\"tmm_scblock\"><\/div><\/div><\/div><span class=\"tmm_two_containers_tablet\"><\/span><\/div><span class=\"tmm_columns_containers_desktop\"><\/span><div class=\"tmm_container\"><div class=\"tmm_member\" style=\"border-top:#006293 solid 5px;\"><div class=\"tmm_photo tmm_pic_research-group-ciccodicola_4\" style=\"background: url(https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/01\/DSC_0388.jpg); margin-left: auto; margin-right:auto; background-size:cover !important;\"><\/div><div class=\"tmm_textblock\"><div class=\"tmm_names\"><span class=\"tmm_fname\">Simona<\/span> <span class=\"tmm_lname\">Cataldi<\/span><\/div><div class=\"tmm_job\">Junior Postdoc (AIRC funded)<\/div><div class=\"tmm_desc\" style=\"text-align:\"><p><strong>e-mail:<\/strong> <a href=\"mailto:simona.cataldi@igb.cnr.it\">simona.cataldi@igb.cnr.it<\/a><\/p><p><strong>Project Title<\/strong>: Assessing COMET Silencing as new Therapeutic Option in Braf-Mutated Thyroid Carcinomas<\/p><\/div><div class=\"tmm_scblock\"><\/div><\/div><\/div><div style=\"clear:both;\"><\/div><\/div><\/div><\/div>                    <\/div>\n\t\t                    <\/div>\n        <\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Alfredo Ciccodicola Acting Director +39 081 6132259\u00a0 \u00a0 alfredo.ciccodicola@igb.cnr.it Genetics, Genomics and Epigenetics of Diseases Keywords: Human diseases, Diabetic Retinopathy, Next Generation Sequencing, transcriptional regulation, epigenetic regulation, alternative splicing, computational analysis. \u00a0 Research Interest Selected Publications Professional Experience Research Group The scientific interests of my research group are mainly aimed at studying the molecular mechanisms [&hellip;]<\/p>\n","protected":false},"author":56,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"class_list":["post-2462","page","type-page","status-publish","czr-hentry"],"_links":{"self":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages\/2462","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/users\/56"}],"replies":[{"embeddable":true,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/comments?post=2462"}],"version-history":[{"count":74,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages\/2462\/revisions"}],"predecessor-version":[{"id":19436,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages\/2462\/revisions\/19436"}],"wp:attachment":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/media?parent=2462"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}