{"id":2464,"date":"2021-03-02T13:07:11","date_gmt":"2021-03-02T12:07:11","guid":{"rendered":"https:\/\/www.igb.cnr.it\/?page_id=2464"},"modified":"2024-07-17T14:47:40","modified_gmt":"2024-07-17T12:47:40","slug":"valerio-costa","status":"publish","type":"page","link":"https:\/\/www.igb.cnr.it\/index.php\/valerio-costa\/","title":{"rendered":"Valerio Costa"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2464\" class=\"elementor elementor-2464\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-43037f4b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"43037f4b\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-49ed1913\" data-id=\"49ed1913\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5c7f825b elementor-widget elementor-widget-bdt-member\" data-id=\"5c7f825b\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;none&quot;}\" data-widget_type=\"bdt-member.bdt-phaedra\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"bdt-member skin-phaedra bdt-transition-toggle\">\n\t\t\t\n\t\t\t\t<div class=\"bdt-member-photo-wrapper\">\n\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"bdt-member-photo\">\n\t\t\t\t\t\t<div class=\"\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/10\/DSC_0434.jpg\" title=\"DSC_0434\" alt=\"DSC_0434\" loading=\"lazy\" \/>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t<\/div>\n\n\t\t\t\n\t\t\t<div class=\"bdt-member-overlay bdt-overlay-default bdt-position-cover bdt-transition-fade bdt-position-z-index\">\n\t\t\t\t<div class=\"bdt-member-desc bdt-position-center bdt-text-center\">\n\t\t\t\t\t<div class=\"bdt-member-content bdt-transition-slide-top-small\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-3ba781bc\" data-id=\"3ba781bc\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-739f77da elementor-widget elementor-widget-heading\" data-id=\"739f77da\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Valerio Costa<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-676302ba elementor-widget elementor-widget-text-editor\" data-id=\"676302ba\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3><strong><span style=\"color: #006293\">Senior Researcher<\/span><\/strong><\/h3><div><p><strong><img decoding=\"async\" class=\"alignnone wp-image-2318\" src=\"http:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona.png\" alt=\"\" width=\"17\" height=\"17\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona.png 512w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-300x300.png 300w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-150x150.png 150w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-270x250.png 270w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-510x510.png 510w\" sizes=\"(max-width: 17px) 100vw, 17px\" \/> +39 081 6132 617 \u00a0 \u00a0<img decoding=\"async\" class=\"alignnone wp-image-2317\" src=\"http:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png\" alt=\"\" width=\"19\" height=\"19\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png 512w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-300x300.png 300w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-150x150.png 150w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-270x250.png 270w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-510x510.png 510w\" sizes=\"(max-width: 19px) 100vw, 19px\" \/> valerio.costa@igb.cnr.it<\/strong><\/p><p><strong>Genetics, Genomics and Epigenetics of Diseases<\/strong><\/p><p><strong>Molecular Oncology<\/strong><\/p><p><strong>Keywords: <\/strong>Molecular Oncology; metabolism; obesity; computational biology<\/p><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0247bd2 e-grid-align-left elementor-shape-rounded elementor-grid-0 elementor-widget elementor-widget-social-icons\" data-id=\"0247bd2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"social-icons.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-social-icons-wrapper elementor-grid\">\n\t\t\t\t\t\t\t<span class=\"elementor-grid-item\">\n\t\t\t\t\t<a class=\"elementor-icon elementor-social-icon elementor-social-icon- elementor-animation-grow-rotate elementor-repeater-item-021f1e1\" href=\"https:\/\/scholar.google.com\/citations?user=Im7fqEEAAAAJ&#038;hl=it\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-screen-only\"><\/span>\n\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"#000000\" viewBox=\"0 0 50 50\" width=\"100px\" height=\"100px\"><path d=\"M 25 2 C 12.309534 2 2 12.309534 2 25 C 2 37.690466 12.309534 48 25 48 C 37.690466 48 48 37.690466 48 25 C 48 12.309534 37.690466 2 25 2 z M 25 4 C 36.609534 4 46 13.390466 46 25 C 46 36.609534 36.609534 46 25 46 C 13.390466 46 4 36.609534 4 25 C 4 13.390466 13.390466 4 25 4 z M 21 11 L 11 20 L 17.78125 20 C 17.80125 22.847 19.967531 25.730469 23.769531 25.730469 C 24.129531 25.730469 24.529688 25.690391 24.929688 25.650391 C 24.749688 26.100391 24.560547 26.470078 24.560547 27.080078 C 24.560547 28.230078 25.140391 28.920078 25.650391 29.580078 C 24.020391 29.690078 20.989766 29.879531 18.759766 31.269531 C 16.629766 32.559531 15.980469 34.43 15.980469 35.75 C 15.980469 38.47 18.500469 41 23.730469 41 C 29.930469 41 33.220703 37.510547 33.220703 34.060547 C 33.220703 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elementor-element-67b36d35\" data-id=\"67b36d35\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-46fb04ba elementor-widget elementor-widget-eael-adv-tabs\" data-id=\"46fb04ba\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"eael-adv-tabs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t        <div data-scroll-on-click=\"no\" data-scroll-speed=\"300\" id=\"eael-advance-tabs-46fb04ba\" class=\"eael-advance-tabs eael-tabs-horizontal eael-tab-auto-active \" data-tabid=\"46fb04ba\">\n            <div class=\"eael-tabs-nav\">\n                <ul class=\"\" role=\"tablist\">\n                                            <li id=\"research-interest\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"research-interest-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >Research Interest<\/span>                                                    <\/li>\n                                            <li id=\"selected-publications\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"selected-publications-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >Selected Publications<\/span>                                                    <\/li>\n                                            <li id=\"professional-experience\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"false\" data-tab=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"professional-experience-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >Professional Experience<\/span>                                                    <\/li>\n                                            <li id=\"associated-people\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"false\" data-tab=\"4\" role=\"tab\" tabindex=\"-1\" aria-controls=\"associated-people-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >Associated People<\/span>                                                    <\/li>\n                                    <\/ul>\n            <\/div>\n            \n            <div class=\"eael-tabs-content\">\n\t\t        \n                    <div id=\"research-interest-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"research-interest-tab\">\n\t\t\t\t        <p>The <em>Unit of Molecular and Computational Biology<\/em> combines molecular and cellular biology techniques to computational tools and next-generation sequencing technologies in the context of <strong>cancer<\/strong> and <strong>metabolic diseases<\/strong>. The research efforts are devoted to:<\/p><p><strong>\u00a0<\/strong><\/p><p><strong>Targeting long non-coding RNAs and metabolism in cancer.<\/strong><\/p><p>The main research interest is to identify new therapeutic strategies for <em>BRAF<\/em>-driven thyroid carcinomas based on the targeting of tumor-specific long non-coding RNAs and of tumor metabolic vulnerabilities.<\/p><p>This research line, currently focused on papillary and anaplastic thyroid carcinomas, aims 1) to <em>functionally characterize tumor-associated lncRNAs, <\/em>evaluate, <em>in vitro<\/em> and <em>in vivo<\/em>, their oncogenic potential and to evaluate their targeting as co-adjuvant of drug-based therapies; 2) to <em>explore metabolic reprogramming<\/em> of tumor cells as Achille\u2019s heel to improve the effectiveness of available targeted therapies.<\/p><p>\u00a0<\/p><p><strong>Dissecting the contribution of <em>PPARG<\/em> isoforms to adipose tissue pathophysiology.<\/strong><\/p><p>The research interest is to define if, and how, alterations in the splicing pattern of the transcription factor PPARG in adipose tissue contribute to human metabolic disorders. This research line combines functional approaches in cell models (adipose tissue-derived mesenchymal stem cells and mature adipocytes) to advanced (NGS) and standard molecular techniques on human samples, and aims 1) to <em>explore the role of PPARG dominant negative isoforms in adipocyte biology<\/em>, from their commitment to terminal differentiation; 2) to <em>evaluate the functional relevance<\/em> of these isoforms in pathological conditions such as hypertrophic obesity and type 2 diabetes.<\/p>                    <\/div>\n\t\t        \n                    <div id=\"selected-publications-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"selected-publications-tab\">\n\t\t\t\t        <p><strong>Targeting long non-coding RNAs and metabolism in cancer.<\/strong><\/p><ul><li>Aprile M, Cataldi S, Perfetto C, Federico A, Ciccodicola A, <strong>Costa V.<\/strong> <a href=\"https:\/\/www.nature.com\/articles\/s41416-023-02282-2\">Targeting metabolism by B-raf inhibitors and diclofenac restrains the viability of BRAF-mutated thyroid carcinomas with Hif-1\u03b1-mediated glycolytic phenotype.<\/a> <em><strong>Br J Cancer.<\/strong><\/em> 2023 Aug;129(2):249-265. doi: 10.1038\/s41416-023-02282-2. Epub 2023 May 17. PMID: 37198319; PMCID: PMC10338540.<\/li><li><div><b><span lang=\"EN-US\">Costa V<\/span><\/b><span lang=\"EN-US\">, Giovannetti E, Lonardo E. <a href=\"https:\/\/www.mdpi.com\/2072-6694\/16\/1\/132\">Revolutionizing Cancer Treatment: Unveiling New Frontiers by Targeting the (Un)Usual Suspects. <\/a><\/span><\/div><div><b><i>Cancers <\/i><\/b>(Basel). 2023 Dec 27;16(1):132. doi: 10.3390\/cancers16010132<\/div><\/li><li>Aprile M, <strong>Costa V<\/strong>, Cimmino A, Calin GA. <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.34282\">Emerging role of oncogenic long non-coding RNA as cancer biomarkers<\/a>. <em><strong>Int J Cancer<\/strong>.<\/em> 2022 Sep 8. doi: 10.1002\/ijc.34282. Epub ahead of print. PMID: 36082440.<\/li><li>Federico A, Fratello M, Scala G, M\u00f6bus L, Pavel A, Del Giudice G, Ceccarelli M, <strong>Costa V<\/strong>, Ciccodicola A, Fortino V, Serra A, Greco D. <a href=\"https:\/\/www.mdpi.com\/2072-6694\/14\/8\/2043\">Integrated Network Pharmacology Approach for Drug Combination Discovery: A Multi-Cancer Case Study<\/a>. <em><strong>Cancers<\/strong><\/em> (Basel). 2022 Apr 18;14(8):2043. doi: 10.3390\/cancers14082043. PMID: 35454948; PMCID: PMC9028433.<\/li><li>Terreri S, Mancinelli S, Ferro M, Vitale MC, Perdon\u00e0 S, Castaldo L, Gigantino V, Mercadante V, De Cecio R, Aquino G, Montella M, Angelini C, Del Prete E, Aprile M, Ciaramella A, Liguori GL, <strong>Costa V<\/strong>, Calin GA, La Civita E, Terracciano D, Febbraio F, Cimmino A. <a href=\"https:\/\/www.mdpi.com\/2072-6694\/13\/4\/681\">Subcellular Localization of uc.8+ as a Prognostic Biomarker in Bladder Cancer Tissue<\/a>. <strong><em>Cancers<\/em><\/strong> (Basel). 2021 Feb 8;13(4):681. PMID: 33567603.<\/li><li>Aprile M, Katopodi V, Leucci E, <strong>Costa V<\/strong>. <a href=\"https:\/\/www.mdpi.com\/2072-6694\/12\/11\/3220\">LncRNAs in Cancer: From garbage to Junk<\/a>. <strong><em>Cancers<\/em><\/strong> (Basel). 2020 Oct 31;12(11):E3220. PMID: 33142861.<\/li><li>Cave DD, Di Guida M, <strong>Costa V<\/strong>, Sevillano M, Ferrante L, Heeschen C, Corona M, Cucciardi A, Lonardo E. <a href=\"https:\/\/www.nature.com\/articles\/s41388-020-1289-1\">TGF-\u03b21 secreted by pancreatic stellate cells promotes stemness and tumourigenicity in pancreatic cancer cells through L1CAM downregulation<\/a>. <strong><em>Oncogene<\/em><\/strong>. 2020 Apr 14.<\/li><li>Malapelle U, Pepe F, Pisapia P, Sgariglia R, Nacchio M, De Luca C, Lacalamita R, Tommasi S, Pinto R, Palomba G, Palmieri G, Vacirca D, Barberis M, Bottillo I, Grammatico P, Grillo LR, <strong>Costa V<\/strong>, Smeraglio R, Bruzzese D, Troncone G. <a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2020.00236\/full\">Harmonization of Next-Generation Sequencing Procedure in Italian Laboratories: A Multi-Institutional Evaluation of the SiRe\u00ae Panel.<\/a> <em><strong>Front Oncol<\/strong>.<\/em> 2020 Mar 11;10:236. doi: 10.3389\/fonc.2020.00236. PMID: 32219061; PMCID: PMC7078327.<\/li><li>Esposito R, Esposito D, Pallante P, Fusco A, Ciccodicola A, <strong>Costa V<\/strong>. <a href=\"https:\/\/aacrjournals.org\/cancerres\/article\/79\/9\/2124\/640914\/Oncogenic-Properties-of-the-Antisense-lncRNA-COMET\">Oncogenic Properties of the Antisense lncRNA COMET in BRAF- and RET-Driven Papillary Thyroid Carcinomas.<\/a> <strong><em>Cancer Research<\/em><\/strong>. 2019 May 1;79(9):2124-2135.<\/li><li>Ambrosio MR, D&#8217;Esposito V, <strong>Costa V<\/strong>, Liguoro D, Collina F, Cantile M, Prevete N, Passaro C, Mosca G, De Laurentiis M, Di Bonito M, Botti G, Franco R, Beguinot F, Ciccodicola A, Formisano P. <a href=\"https:\/\/www.oncotarget.com\/article\/22552\/text\/\">Glucose impairs tamoxifen responsiveness modulating Connective Tissue Growth Factor in breast cancer cells<\/a>. <strong><em>Oncotarget<\/em><\/strong> 2017 Nov 20;8(65):109000-109017.<\/li><li>Terracciano D, Terreri S, de Nigris F, <strong>Costa V<\/strong>, Calin GA, Cimmino A. <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0304419X17301105?via%3Dihub\">The role of a new class of long non-coding RNAs transcribed from ultraconserved regions in cancer<\/a>. <strong><em>BBA Rev Cancer<\/em> <\/strong>2017 Sep 12. pii: S0304-419X(17)30110-5. doi: 10.1016\/j.bbcan.2017.09.001.<\/li><li>Federico A, Rienzo M, Abbondanza C, <strong>Costa V<\/strong>, Ciccodicola A, Casamassimi A. <a href=\"https:\/\/www.mdpi.com\/1422-0067\/18\/5\/936\">Pan-Cancer Mutational and Transcriptional Analysis of the Integrator Complex<\/a>. <strong><em>Int J Mol Sci.<\/em><\/strong> 2017 Apr 29;18(5).<\/li><li>Petrizzo A, Caruso FP, Tagliamonte M, Tornesello ML, Ceccarelli M, <strong>Costa V<\/strong>, Aprile M, Esposito R, Ciliberto G, Buonaguro FM, Buonaguro L. <a href=\"https:\/\/www.nature.com\/articles\/srep29258\">Identification and Validation of HCC-specific Gene Transcriptional Signature for Tumor Antigen Discovery<\/a>. <strong><em>Scientific Reports<\/em><\/strong>. 2016 Jul 8;6:29258.<\/li><li><strong>Costa V<\/strong>, Esposito R, Pallante P, Ciccodicola A and Fusco. <a href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/15384101.2015.1049786\">The &#8220;next-generation&#8221; knowledge of papillary thyroid carcinoma<\/a>. <strong><em>Cell Cycle<\/em><\/strong>, 2015 Jun 1:0.<\/li><li><strong>Costa V<\/strong>, Esposito R, Ziviello C, Sepe R, Bim LV, Cacciola NA, Decaussin-Petrucci M, Pallante P, Fusco A and Ciccodicola. <a href=\"https:\/\/www.oncotarget.com\/article\/3593\/text\/\">New somatic mutations and <em>WNK1<\/em>&#8211;<em>B4GALNT3<\/em> gene fusion in papillary thyroid carcinoma<\/a>. <strong><em>Oncotarget. <\/em><\/strong>2015 Mar 14.<\/li><\/ul><p><strong>Dissecting the contribution of <em>PPARG<\/em> isoforms to adipose tissue pathophysiology<\/strong><\/p><ul><li>Cataldi S, Aprile M, Perfetto C, Angot B, Cormont M, Ciccodicola A, Tanti JF, <strong>Costa V<\/strong>. <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0171933523000353?via%3Dihub\">GIPR expression is induced by thiazolidinediones in a PPAR\u03b3-independent manner and repressed by obesogenic stimuli.<\/a> <em><strong>Eur J Cell Biol.<\/strong><\/em> 2023 Jun;102(2):151320. doi: 10.1016\/j.ejcb.2023.151320. Epub 2023 Apr 26. PMID: 37130450.<\/li><li>Cataldi S, Tramontano M, <strong>Costa V<\/strong>, Aprile M, Ciccodicola A. <a href=\"https:\/\/www.mdpi.com\/2076-3921\/11\/10\/2021\">Diabetic Retinopathy: Are lncRNAs New Molecular Players and Targets?<\/a> <em><strong>Antioxidants<\/strong><\/em> (Basel). 2022 Oct 12;11(10):2021. doi: 10.3390\/antiox11102021. PMID: 36290744; PMCID: PMC9598326.<\/li><li>Cataldi S, Aprile M, Melillo D, Mucel I, Giorgetti-Peraldi S, Cormont M, Italiani P, Bl\u00fcher M, Tanti JF, Ciccodicola A, <strong>Costa V*.<\/strong> <a href=\"https:\/\/www.mdpi.com\/2073-4409\/11\/1\/42\">TNF\u03b1 Mediates Inflammation-Induced Effects on\u00a0<em>PPARG\u00a0<\/em>Splicing in Adipose Tissue and Mesenchymal Precursor Cells<\/a>. <em><strong>Cells<\/strong><\/em> 2021 Dec 24;11(1):42. doi: 10.3390\/cells11010042.<\/li><li>Cataldi, S., <strong>Costa, V<\/strong>., Ciccodicola, A., and Aprile, M. (2021). <a href=\"https:\/\/link.springer.com\/article\/10.1007\/s11892-021-01385-5\">PPAR\u03b3 and Diabetes: Beyond the Genome and Towards Personalized Medicine.<\/a> <strong><em>Current diabetes reports<\/em><\/strong>, 21(6), 18.<\/li><li>Aprile M, Cataldi S, Perfetto C, Ambrosio MR, Italiani P, Tat\u00e8 R, Bl\u00fcher M, Ciccodicola A, <strong>Costa V*.<\/strong> (2020). <a href=\"https:\/\/www.mdpi.com\/2073-4409\/9\/5\/1284\">In Vitro-Generated Hypertrophic-Like Adipocytes Displaying <em>PPARG<\/em> Isoforms Unbalance Recapitulate Adipocyte Dysfunctions In Vivo<\/a>. <strong><em>Cells<\/em><\/strong><strong>,<\/strong> <em>9<\/em>(5), E1284.<\/li><li>Aprile M, Cataldi S, Ambrosio MR, D&#8217;Esposito V, Lim K, Dietrich A, Bl\u00fcher M, Savage DB, Formisano P, Ciccodicola A, <strong>Costa V*<\/strong>. <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2211124718316115?via%3Dihub\">PPAR\u03b3\u03945, a Naturally Occurring Dominant-Negative Splice Isoform, Impairs PPAR\u03b3 Function and Adipocyte Differentiation<\/a>. <strong><em>Cell Reports.<\/em><\/strong> 2018 Nov 6;25(6):1577-1592.e6.<\/li><li>Parrillo L, <strong>Costa V<\/strong>, Raciti G, Longo M, Spinelli R, Esposito R, Nigro C, Vastolo V, Desiderio A, Zatterale F, Ciccodicola A, Formisano P, Miele C, and Beguinot F. <a href=\"https:\/\/www.nature.com\/articles\/ijo201636\">Hoxa5 undergoes dynamic DNA methylation and transcriptional repression in the adipose tissue of mice exposed to high-fat diet.<\/a> <strong><em>Int J Obesity<\/em><\/strong> (Lond). 2016, Mar 16.<\/li><li>Pollastro C, Ziviello C, <strong>Costa V<\/strong> and Ciccodicola A. <a href=\"https:\/\/www.hindawi.com\/journals\/ppar\/2015\/415149\/\">Pharmacogenomics of Drug Response in Type 2 Diabetes: Toward the Definition of Tailored Therapies?\u00a0<\/a><strong><em>PPAR Research<\/em><\/strong>.<\/li><li>Aprile M, Ambrosio MR, D&#8217;Esposito V, Beguinot F, Formisano P, <strong>Costa V* and<\/strong> Ciccodicola A. <a href=\"https:\/\/www.hindawi.com\/journals\/ppar\/2014\/537865\/\">PPARG in human adipogenesis: differential contribution of canonical transcripts and dominant negative isoforms<\/a>. <strong><em>PPAR Res.<\/em><\/strong> 2014<em>.<\/em><\/li><li><strong>Costa V<\/strong>, Ciccodicola A. <a href=\"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/j.1476-5381.2011.01443.x\">Is PPARG the key gene in diabetic retinopathy?<\/a> <strong><em>Br J Pharmacol.<\/em><\/strong> 2012 Jan; 165(1):1-3. doi: 10.1111\/j.1476-5381.2011.01443.x. PubMed PMID: 21501146; PubMed Central PMCID: PMC3252961.\u00a0<\/li><li><strong>Costa V<\/strong>, Gallo MA, Letizia F, Aprile M, Casamassimi A, Ciccodicola A. <a href=\"https:\/\/www.hindawi.com\/journals\/ppar\/2010\/409168\/\">PPARG: Gene Expression Regulation and Next-Generation Sequencing for Unsolved Issues.<\/a> <strong><em>PPAR Res.<\/em><\/strong> 2010;2010. pii: 409168. doi: 10.1155\/2010\/409168. Epub 2010 Sep 8.\u00a0<\/li><li><strong>Costa V<\/strong>, Casamassimi A, Esposito K, Villani A, Capone M, Iannella R, Schisano B, Ciotola M, Di Palo C, Corrado FC, Santangelo F, Giugliano D, Ciccodicola A. <a href=\"https:\/\/www.hindawi.com\/journals\/bmri\/2009\/126917\/\">Characterization of a novel polymorphism in PPARG regulatory region associated with type 2 diabetes and diabetic retinopathy in Italy<\/a>. <strong><em>J Biomed Biotechnol.<\/em><\/strong> 2009; 2009:126917. doi: 10.1155\/2009\/126917. Epub 2008 Dec 25. PubMed PMID: 19125195; PubMed Central PMCID: PMC2610251.\u00a0<\/li><\/ul>                    <\/div>\n\t\t        \n                    <div id=\"professional-experience-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"professional-experience-tab\">\n\t\t\t\t        <p><strong>Education<\/strong><\/p><ul><li>December 2008. <strong>PhD<\/strong> in Metabolism and Ageing &#8211; Faculty of Medicine, University of Campania Luigi Vanvitelli.<\/li><li>March 2005. <strong>MSc<\/strong> in Biotechnology &#8211; Federico II University of Naples.<\/li><\/ul><p><strong>Research and teaching<\/strong><\/p><ul><li>April 2015 &#8211; present. <strong>CNR Researcher<\/strong>, IGB-CNR Naples.<\/li><li>June 2014 &#8211; March 2015. <strong>CNR Researcher<\/strong> (temporary position), IGB-CNR Naples.<\/li><li>June 2013 &#8211; May 2014. <strong>Senior PostDoc fellow<\/strong>, IGB-CNR.<\/li><li>June 2012 &#8211; May 2013. <strong>Junior PostDoc fellow<\/strong>, DiSMET, &#8220;Federico II&#8221; University of Naples.<\/li><li>2011-present. <strong>Teaching Assistant<\/strong> in Molecular Biology, \u201cParthenope\u201d University.<\/li><li>January 2009 &#8211; May 2012. <strong>Junior PostDoc fellow<\/strong>, IGB-CNR.<\/li><li>2009-2019. <strong>Teaching Assistant<\/strong> in Genetics, \u201cParthenope\u201d University of Naples.<\/li><\/ul><p><strong>Awards and Honors<\/strong><\/p><ul><li>Qualified as<strong><em> Associate Professor<\/em><\/strong> in <em>Genetics <\/em>(valid until 2033)<\/li><li>Qualified as<strong><em> Associate Professor<\/em><\/strong> in <em>Molecular Biology <\/em>(valid until 2031)<\/li><li>Qualified as<strong><em> Associate Professor<\/em><\/strong> in <em>General and Clinical Pathology <\/em>(valid until 2031)<\/li><li><strong><em>Member <\/em><\/strong>of the IGB-CNR International Workshop Organizing Committee<\/li><li>Winner of<strong><em> International Scientific Award &#8220;Nunzio Pascale&#8221; (<\/em><\/strong><em>XXI Edition), <\/em>October 2016<\/li><li><strong><em>Editorial Board Member<\/em><\/strong>, Hereditas<\/li><li><strong><em>Associate Editor<\/em><\/strong>, Frontiers in Genetics, section <em>Cancer Genetics and Oncogenomics<\/em><\/li><li><strong><em>Review Editor<\/em><\/strong>, Frontiers in Genetics, section <em>Applied Genetic Epidemiology <\/em><\/li><li><strong><em>Topic Editor<\/em><\/strong>, Cancers<\/li><li><strong><em>Editorial Board Member<\/em><\/strong>, Journal of Human Transcriptome (past position)<\/li><\/ul><p><strong>Current research grants (funded as PI or as member of research unit)<\/strong><\/p><ul><li>2023-2025. <strong>Prin PNRR 2022.<\/strong> \u201cDefining the impact of obesity on cellular heterogeneity of peritumoral adipose tissue in breast cancer\u201d (cod. P2022LPJM4). PI of CNR Unit.<\/li><li>2022-2025. National Recovery and Resilience Plan (<strong>PNRR<\/strong>), Mission 4, Component 2, Investment 1.4 funded from the European Union \u2013 NextGenerationEU, National Biodiversity Future Center (NBFC). PI<\/li><li>2020-2025. <strong>MFAG<\/strong> (My First AIRC Grant) &#8220;<em>Assessing COMET Silencing as new Therapeutic Option in Braf-Mutated Thyroid Carcinomas<\/em>&#8220;. PI of the Project.<\/li><li>2023-2024. Progetto di interesse strategico <strong>INVECCHIAMENTO<\/strong> (DSB.AD009). Member of IGB-CNR Unit.<\/li><li>2023-2024. <strong>NUTRAGE CNR<\/strong> FOE-2021 (DBA.AD005.225). Member of IGB-CNR Unit.<\/li><li>2019-2021. <strong>PON<\/strong> &#8220;Innovative Devices For SHAping the RIsk of Diabetes (IDF SHARID)&#8221;. Member of IGB-CNR Unit.<\/li><li>2018-2020. <strong>POR Campania FESR<\/strong> 2014\/2020 &#8220;Sviluppo di Approcci Terapeutici INnovativi per patologie neoplastiche resistenti ai trattamenti (SATIN)&#8221;. Member of IGB-CNR Unit.<\/li><\/ul>                    <\/div>\n\t\t        \n                    <div id=\"associated-people-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"associated-people-tab\">\n\t\t\t\t        <div class=\"tmm tmm_associated-people-costa\"><div class=\"tmm_2_columns tmm_wrap tmm_plugin_f\"><span class=\"tmm_two_containers_tablet\"><\/span><div class=\"tmm_container\"><div class=\"tmm_member\" style=\"border-top:#006293 solid 5px;\"><a target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.igb.cnr.it\/index.php\/marianna-aprile\/\" title=\"Marianna Aprile\"><div class=\"tmm_photo tmm_pic_associated-people-costa_0\" style=\"background: url(https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/01\/DSC_0393.jpg); margin-left: auto; margin-right:auto; background-size:cover !important;\"><\/div><\/a><div class=\"tmm_textblock\"><div class=\"tmm_names\"><span class=\"tmm_fname\">Marianna<\/span> <span class=\"tmm_lname\">Aprile<\/span><\/div><div class=\"tmm_job\">CNR Researcher (AIRC funded)<\/div><div class=\"tmm_desc\" style=\"text-align:\"> marianna.aprile@igb.cnr.itProject Title: Assessing COMET Silencing as new Therapeutic Option in Braf-Mutated Thyroid Carcinomas<\/div><div class=\"tmm_scblock\"><\/div><\/div><\/div><div class=\"tmm_member\" style=\"border-top:#006293 solid 5px;\"><a target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.igb.cnr.it\/index.php\/simona-cataldi\/\" title=\"Simona Cataldi\"><div class=\"tmm_photo tmm_pic_associated-people-costa_1\" style=\"background: url(https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/01\/DSC_0388.jpg); margin-left: auto; margin-right:auto; background-size:cover !important;\"><\/div><\/a><div class=\"tmm_textblock\"><div class=\"tmm_names\"><span class=\"tmm_fname\">Simona<\/span> <span class=\"tmm_lname\">Cataldi<\/span><\/div><div class=\"tmm_job\">CNR Researcher (Prin PNRR funded)<\/div><div class=\"tmm_desc\" style=\"text-align:\"> simona.cataldi@igb.cnr.itProject Title: Defining the impact of obesity on cellular heterogeneity of peritumoral adipose tissue in breast cancer (P2022LPJM4)<\/div><div class=\"tmm_scblock\"><\/div><\/div><\/div><span class=\"tmm_two_containers_tablet\"><\/span><\/div><span class=\"tmm_columns_containers_desktop\"><\/span><div class=\"tmm_container\"><div class=\"tmm_member\" style=\"border-top:#006293 solid 5px;\"><div class=\"tmm_photo tmm_pic_associated-people-costa_2\" style=\"background: url(https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/01\/DSC_0391.jpg); margin-left: auto; margin-right:auto; background-size:cover !important;\"><\/div><div class=\"tmm_textblock\"><div class=\"tmm_names\"><span class=\"tmm_fname\">Caterina<\/span> <span class=\"tmm_lname\">Perfetto<\/span><\/div><div class=\"tmm_job\">(CNR funded)<\/div><div class=\"tmm_desc\" style=\"text-align:\"> caterina.perfetto@igb.cnr.itProgetto Invecchiamento\u00a0CNR<\/div><div class=\"tmm_scblock\"><\/div><\/div><\/div><div style=\"clear:both;\"><\/div><\/div><\/div><\/div>                    <\/div>\n\t\t                    <\/div>\n        <\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Valerio Costa Senior Researcher +39 081 6132 617 \u00a0 \u00a0 valerio.costa@igb.cnr.it Genetics, Genomics and Epigenetics of Diseases Molecular Oncology Keywords: Molecular Oncology; metabolism; obesity; computational biology Research Interest Selected Publications Professional Experience Associated People The Unit of Molecular and Computational Biology combines molecular and cellular biology techniques to computational tools and next-generation sequencing technologies in [&hellip;]<\/p>\n","protected":false},"author":68,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"class_list":["post-2464","page","type-page","status-publish","czr-hentry"],"_links":{"self":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages\/2464","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/users\/68"}],"replies":[{"embeddable":true,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/comments?post=2464"}],"version-history":[{"count":82,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages\/2464\/revisions"}],"predecessor-version":[{"id":17532,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages\/2464\/revisions\/17532"}],"wp:attachment":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/media?parent=2464"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}