{"id":2474,"date":"2021-03-02T13:08:24","date_gmt":"2021-03-02T12:08:24","guid":{"rendered":"https:\/\/www.igb.cnr.it\/?page_id=2474"},"modified":"2023-09-20T13:14:51","modified_gmt":"2023-09-20T11:14:51","slug":"teresa-esposito","status":"publish","type":"page","link":"https:\/\/www.igb.cnr.it\/index.php\/teresa-esposito\/","title":{"rendered":"Teresa Esposito"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2474\" class=\"elementor elementor-2474\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2fa7e344 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2fa7e344\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-141e1669\" data-id=\"141e1669\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-14380a28 elementor-widget elementor-widget-bdt-member\" data-id=\"14380a28\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;none&quot;}\" data-widget_type=\"bdt-member.bdt-phaedra\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"bdt-member skin-phaedra bdt-transition-toggle\">\n\t\t\t\n\t\t\t\t<div class=\"bdt-member-photo-wrapper\">\n\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"bdt-member-photo\">\n\t\t\t\t\t\t<div class=\"\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/10\/DSC_0414.jpg\" title=\"DSC_0414\" alt=\"DSC_0414\" loading=\"lazy\" \/>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t<\/div>\n\n\t\t\t\n\t\t\t<div class=\"bdt-member-overlay bdt-overlay-default bdt-position-cover bdt-transition-fade bdt-position-z-index\">\n\t\t\t\t<div class=\"bdt-member-desc bdt-position-center bdt-text-center\">\n\t\t\t\t\t<div class=\"bdt-member-content bdt-transition-slide-top-small\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-12f62b6d\" data-id=\"12f62b6d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-483bb5bb elementor-widget elementor-widget-heading\" data-id=\"483bb5bb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Teresa Esposito<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1182274 elementor-widget elementor-widget-text-editor\" data-id=\"1182274\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3><strong><span style=\"color: #006293;\">Senior Researcher<\/span><\/strong><\/h3><div><p><strong> <img decoding=\"async\" class=\"alignnone wp-image-2318\" src=\"http:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona.png\" alt=\"\" width=\"17\" height=\"17\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona.png 512w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-300x300.png 300w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-150x150.png 150w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-270x250.png 270w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-510x510.png 510w\" sizes=\"(max-width: 17px) 100vw, 17px\" \/> +39 081 6132330-258 \u00a0 \u00a0<img decoding=\"async\" class=\"alignnone wp-image-2317\" src=\"http:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png\" alt=\"\" width=\"19\" height=\"19\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png 512w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-300x300.png 300w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-150x150.png 150w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-270x250.png 270w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-510x510.png 510w\" sizes=\"(max-width: 19px) 100vw, 19px\" \/> teresa.esposito@igb.cnr.it<\/strong><\/p><p><strong>Genetics, Genomics and Epigenetics of Diseases\/ Neuroscience<br \/><\/strong><\/p><p><strong>Keywords: <\/strong>Genetics of human diseases, Molecular bases of Parkinson\u2019s disease<\/p><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9ac8863 e-grid-align-left elementor-shape-rounded elementor-grid-0 elementor-widget elementor-widget-social-icons\" data-id=\"9ac8863\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"social-icons.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-social-icons-wrapper elementor-grid\" role=\"list\">\n\t\t\t\t\t\t\t<span class=\"elementor-grid-item\" role=\"listitem\">\n\t\t\t\t\t<a class=\"elementor-icon elementor-social-icon elementor-social-icon- elementor-animation-grow-rotate elementor-repeater-item-021f1e1\" href=\"https:\/\/scholar.google.com\/citations?user=w7qWEYYAAAAJ&#038;hl=it\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-screen-only\"><\/span>\n\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"#000000\" viewBox=\"0 0 50 50\" width=\"100px\" height=\"100px\"><path d=\"M 25 2 C 12.309534 2 2 12.309534 2 25 C 2 37.690466 12.309534 48 25 48 C 37.690466 48 48 37.690466 48 25 C 48 12.309534 37.690466 2 25 2 z M 25 4 C 36.609534 4 46 13.390466 46 25 C 46 36.609534 36.609534 46 25 46 C 13.390466 46 4 36.609534 4 25 C 4 13.390466 13.390466 4 25 4 z M 21 11 L 11 20 L 17.78125 20 C 17.80125 22.847 19.967531 25.730469 23.769531 25.730469 C 24.129531 25.730469 24.529688 25.690391 24.929688 25.650391 C 24.749688 26.100391 24.560547 26.470078 24.560547 27.080078 C 24.560547 28.230078 25.140391 28.920078 25.650391 29.580078 C 24.020391 29.690078 20.989766 29.879531 18.759766 31.269531 C 16.629766 32.559531 15.980469 34.43 15.980469 35.75 C 15.980469 38.47 18.500469 41 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data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"eael-adv-tabs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t        <div data-scroll-on-click=\"no\" data-scroll-speed=\"300\" id=\"eael-advance-tabs-6390e320\" class=\"eael-advance-tabs eael-tabs-horizontal eael-tab-auto-active \" data-tabid=\"6390e320\">\n            <div class=\"eael-tabs-nav\">\n                <ul class=\"\" role=\"tablist\">\n                                            <li id=\"research-interest\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"research-interest-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >Research Interest<\/span>                                                    <\/li>\n                                            <li id=\"selected-publications\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"selected-publications-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >Selected Publications<\/span>                                                    <\/li>\n                                            <li id=\"professional-experience\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"false\" data-tab=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"professional-experience-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >Professional Experience<\/span>                                                    <\/li>\n                                            <li id=\"research-group\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"false\" data-tab=\"4\" role=\"tab\" tabindex=\"-1\" aria-controls=\"research-group-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >Research Group<\/span>                                                    <\/li>\n                                    <\/ul>\n            <\/div>\n            \n            <div class=\"eael-tabs-content\">\n\t\t        \n                    <div id=\"research-interest-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"research-interest-tab\">\n\t\t\t\t        <p>The project of our research group aims at the identification of novel biomarkers for early prediction and progression of Parkinson&#8217;s Disease\u00a0 through a multidisciplinary approach integrating omics data and in vitro modelling.<\/p><p>Parkinson\u2019s disease (PD) represents one of the most frequent neurodegenerative disorders whose socio-economic impact is enormous. PD is characterized by the loss of mesodiencephalic dopaminergic (mdDA) neurons of the substantia nigra pars compacta (SNpc). It has been demonstrated that disease\u2019s symptoms occur in patients lacking 50-60% of their mdDA neurons, suggesting the need for early diagnosis of the disease and development of innovative therapeutic approaches.<\/p><p>The study takes advantage from the availability of a large collection of PD samples (about 800 PD patients including familiar and sporadic) recruited at IRCCS Neuromed for which we already collected and stored clinical information (neurological examination and drugs therapy), genetic data (WES) as well as DNA, serum, plasma and PBMC for the entire study cohort. Patients-derived fibroblast cell lines have been stored in our biobank and patient-derived induced pluripotent stem cells \u00a0(iPSC) are in progress.<\/p><p><strong>Objectives<\/strong><\/p><p>The project is focused at: i) the realization of diagnostic protocols for an early prediction of<\/p><p>Parkinson&#8217;s disease; ii) studying the effect of the presence of specific variants or combinations of<\/p><p>variants on the severity and progression of the disease; iii) understanding whether and how genetic variants may influence identity and susceptibility to neurodegeneration of hiPSC-derived mdDA neurons carrying highly penetrant genetic combinations of variants in novel PD genes; iv) identifying novel biomarkers for PD through the integrated analysis of clinical, instrumental (PET, DaTScan) and omic data (exome, metabolome and transcriptome (scRNAseq)).<\/p><p><img fetchpriority=\"high\" decoding=\"async\" class=\"size-full wp-image-13410 aligncenter\" src=\"http:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/02\/esp.png\" alt=\"\" width=\"862\" height=\"791\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/02\/esp.png 862w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/02\/esp-300x275.png 300w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/02\/esp-768x705.png 768w\" sizes=\"(max-width: 862px) 100vw, 862px\" \/><\/p>                    <\/div>\n\t\t        \n                    <div id=\"selected-publications-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"selected-publications-tab\">\n\t\t\t\t        <ol><li>Gialluisi A, Reccia MG, Modugno N, Nutile T, Lombardi A, Di Giovannantonio LG, Pietracupa S, \u00a0Ruggiero D, Scala S, Gambardella S; International Parkinson\u2019s Disease Genomics Consortium (IPDGC), Iacoviello L, Gianfrancesco F, Acampora D, D&#8217;Esposito M, Simeone A, Ciullo M, <strong>Esposito T<\/strong>. Identification of sixteen novel candidate genes for late onset Parkinson&#8217;s disease. Mol Neurodegener. 2021 Jun 21;16(1):35. doi: 10.1186\/s13024-021-00455-2.<\/li><li>K\u00f6nig E, Nicoletti A, Pattaro C, Annesi G, Melotti R, Gialluisi A, Schwienbacher C, Picard A, Blankenburg H, Pichler I, Modugno N, Ciullo M, <strong>Esposito T<\/strong>, Domingues FS, Hicks AA, Zappia M, Pramstaller PP. Exome-wide association study of levodopa-induced dyskinesia in Parkinson&#8217;s disease. Sci Rep. 2021 Oct 1;11(1):19582. doi: 10.1038\/s41598-021-99393-8.<\/li><li>Tirozzi A, Modugno N, Palomba NP, Ferese R, Lombardi A, Olivola E, Gialluisi A, <strong>Esposito T<\/strong>. Analysis of genetic and non-genetic predictors of levodopa induced dyskinesia in Parkinson&#8217;s Disease. Front Pharmacol 2021. doi: 10.3389\/fphar.2021.640603.<\/li><li>Napolitano F, Bruno G, Terracciano C, Franzese G, Palomba NP, Scotto di Carlo F, Signoriello E, De Blasiis P, Navarro S, Gialluisi A, Melone MAB, Sampaolo S, <strong>Esposito T<\/strong>. Rare Variants in Autophagy and Non-Autophagy Genes in Late-Onset Pompe Disease: Suggestions of Their Disease-Modifying Role in Two Italian Families. Int J Mol Sci. 2021 Mar 31;22(7):3625. doi: 10.3390\/ijms22073625.<\/li><li>Napolitano F, Terracciano C, Bruno G, De Blasiis P, Lombardi L, Gialluisi A, Gianfrancesco F, De Giovanni D, Tummolo A, Di Iorio G, Limongelli G, <strong>Esposito T<\/strong>, Melone MAB, Sampaolo S. Novel autophagic vacuolar myopathies: Phenotype and genotype features. Neuropathol Appl Neurobiol. 2021 Jan 4. doi: 10.1111\/nan.12690.<\/li><li>Gialluisi A, Reccia MG, Tirozzi A, Nutile T, Lombardi A, De Sanctis C; International Parkinson&#8217;s Disease Genomic Consortium (IPDGC), Varanese S, Pietracupa S, Modugno N, Simeone A, Ciullo M, <strong>Esposito T<\/strong>. Whole Exome Sequencing Study of Parkinson Disease and Related Endophenotypes in the Italian Population. Front Neurol. 2020 Jan 10;10:1362. doi: 10.3389\/fneur.2019.01362.<\/li><li>Scotto di Carlo F, Pazzaglia L, <strong>Esposito T<\/strong>, Gianfrancesco F. The Loss of Profilin 1 Causes Early Onset Paget&#8217;s Disease of Bone. J Bone Miner Res. 2020 Jan 28. doi: 10.1002\/jbmr.3964.<\/li><li>Sampaolo S, Napolitano F, Tirozzi A, Reccia MG, Lombardi L, Farina O, Barra A, Cirillo F, Melone MAB, Gianfrancesco F, Di Iorio G, <strong>Esposito T<\/strong>. Identification of the first dominant mutation of LAMA5 gene causing a complex multisystem syndrome due to dysfunction of the extracellular matrix. J Med Genet. 2017 Oct;54(10):710-720. IF 2017: 5.45. * Corresponding. doi: 10.1136\/jmedgenet-2017-104555. Epub 2017 Jul 22. PMID: 28735299<\/li><li>Divisato G, Formicola D, <strong>Esposito T<\/strong>, Merlotti D, Pazzaglia L, Del Fattore A, Siris E, Orcel P, Brown JP, Nuti R, Strazzullo P, Benassi MS, Cancela ML, Michou L, Rendina D, Gennari L, Gianfrancesco F. ZNF687 Mutations in Severe Paget Disease of Bone Associated with Giant Cell Tumor. Am J Hum Genet. 2016 Feb 4;98(2):275-86.<\/li><li><strong>Esposito T<\/strong>, Sampaolo S, Limongelli G, Varone A, Formicola D, Diodato D, Farina O, Napolitano F, Gianfrancesco F, Di Iorio G. Digenic mutation inheritance of integrin alpha 7 and myosin heavy chain 7B genes causes congenital myopathy with left ventricular non compact cardiomyopathy. <em>Orphanet J. Rare Disease<\/em> 2013, Jun 21;8(1):91. doi: 10.1186\/1750-1172-8-91.<\/li><li><strong>Esposito T<\/strong>, Lea RA, Maher BH, Moses D, Cox HC, Magliocca C, Angius A, Nyholt DL, Titus T, Kay T, Gray NA, Rastaldi MP, Parnham A, Gianfrancesco F, Griffiths LR. Unique X-linked familial FSGS with co-segregating heart block disorder is associated with a mutation in the NXF5 gene. <em>Hum. Mol. Genet<\/em>. 2013, 22 (18): 3654-3666. doi: 10.1093\/hmg\/ddt215.<\/li><li><strong>Esposito T<\/strong>, Rendina D, Mossetti G, De Filippo G, Gianfrancesco F, Perfetti A, Magliocca S, Formisano P, Pri\u00e9 D and Strazzullo P. A functional allelic variant of the FGF23 gene is associated with renal phospate leak in calcium nephrolithiasis. <em>J Clin Endocr Metab, <\/em>2012, 97(5):E840\u2013E844. doi: 10.1210\/jc.2011-1528.<\/li><li><strong> Esposito T<\/strong>, Gianfrancesco F, Ombra MN, Forabosco P, Maninchedda G, Fattorini M, Casula S, Vaccargiu S, Casu G, Cardia F, Deiana I, Melis P, Falchi M, Pirastu M. Identification of a Novel Gene and a Common Variant Associated with Uric Acid Nephrolithiasis in a Sardinian Genetic Isolate. <em>Am. J. Hum. Genet.<\/em>, 2003, 72:1479-1491.<\/li><li>The International Incontinentia Pigmenti (IP) Consortium. The authors SA, HNS, <strong>ET<\/strong>, WH, AS, are equally first author. France (Smahi, A, Courtois G, Vabres, P, Yamaoka S, Solange Heuertz, Munnich A, and Israel A.) Germany (Heiss, NS, Klauck S, Kioschis P, Wiemann S and Poustka A.) Italy (<strong>Esposito T<\/strong>, Bardaro T, Gianfrancesco F, Ciccodicola A and D\u2019Urso M.) U.K (Woffendin H, Jakins T, Donnai D, Stewart H and Kenwrick SJ.) USA (Aradhya S, Yamagata T, Levy, M, Lewis, RA and Nelson, DL.) Genomic rearrangement in Nemo impairs NF-kB activation and is a cause of incontinentia pigmenti <em>Nature <\/em>2000, 405: 466-472. doi:10.1038\/35013114<\/li><li>D&#8217;Esposito M, Ciccodicola A, Gianfrancesco F, <strong>Esposito T<\/strong>, Flagiello L, Mazzarella R, Schlessinger D and D&#8217;Urso M. A synaptobrevin-like gene in the Xq28 pseudoautosomal region undergoes X inactivation. <em>Nature Genetics <\/em><strong>1996<\/strong>, 13, 227-229. IF 1996: 31,473. cit 74 doi:10.1038\/ng0696-227 PMID: 8640232<\/li><\/ol><p>The complete list of publications is available on Google Scholar (Esposito Teresa profile) and at ORCID ID: <a href=\"http:\/\/orcid.org\/0000-0002-7879-8441\">http:\/\/orcid.org\/0000-0002-7879-8441<\/a><\/p>                    <\/div>\n\t\t        \n                    <div id=\"professional-experience-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"professional-experience-tab\">\n\t\t\t\t        <p>Teresa Esposito is presently Senior Researcher and group leader of the Molecular Genetics and Genomics lab of the Institute of Genetics and Biophysics \u201cAdriano Buzzati-Traverso\u201d of the National Research Council (CNR) in Naples. She graduated in Biology at the University of Naples \u201cFederico II\u201d in 1992. In \u00a01998 she completed her PhD training in Medical Embryology at University of Modena Italy and in 1999 she got her specialization in Biotechnological Applications at &#8220;Federico II&#8221; University of Naples, Italy.<\/p><p>From 2001 until 2004 she was Researcher at the Institute of Population Genetics of the CNR in Alghero, Italy, where she acquired a broad background in human genetics and epidemiology. In 2006 she was visiting scientist at Genomics Research Centre, Gold Coast campus, Griffith University, Australia and in 2010 at Integrative Genomics and Medicine Group MRC Clinical Sciences Centre, Imperial College Faculty of Medicine, Hammersmith Hospital, London.<\/p><p>Since 2017 she is Head of the Biobank for rare disease LOPD (Late onset Pompe Disease) which also includes autophagic myopathies and member of the Board of Directors of the Biological Resources Centre (CRB) of the IGB-CNR which is part of the network of Biobanks of the BBMRI (http:\/\/www.igb.cnr.it\/centro-di-risorse-biologiche).<\/p><p>Since 2017 she is Responsible of the CNR Research Unit at IRCCS INM Neuromed, Pozzilli (IS) focused at the realization of diagnostic protocols for an early prediction of Parkinson&#8217;s disease.\u00a0<\/p><p>Teresa Esposito is human molecular geneticist, she has a consolidated expertise in the identification of genes and genetic variants related to human disease. Since 2012 she has moved on the world of \u201comics\u201d technology by using next generation sequencing approach to identify genes\/variants associated to human diseases.<\/p><p><strong>Other experiences<\/strong><\/p><p>Instructor at the Theoretical and Practical Course Embo &#8220;Cloning into YAC vectors III&#8221;, IIGB-CNR, Naples Italy (1994).<\/p><p>Instructor at the Theoretical and Practical Course Embo &#8220;Cloning into YAC vectors II&#8221;, IIGB-CNR, Naples Italy (1992).<\/p><p>Member of the Italian Society of Human Genetics S.I.G.U 1994-2000 and 2016- to date<\/p><p>Member of the American Society of Human Genetics ASHG 2006- to date<\/p><p>Member of the Forum in Bone and Mineral Research 2007-to date<\/p><p>Member of the National Incontinenia Pigmenti Foundation 1998-2001<\/p><p>Tutor of PhD program in Molecular and Cellular Biotechnology of the Second University of Naples (2013-to data).<\/p><p>International Evaluator of Doctoral Thesis of the Griffith University (Australia), Years: 2011 and 2014.<\/p><p><strong>Publications <\/strong><\/p><p>Author of 85 publications and two patents: PCT\/IT2003\/000627 and RM2002A000525.<\/p><p>H-Index: 25 (WOS)<\/p><p>Scopus Author Id: 56213303300<\/p><p>ORCID ID: <a href=\"http:\/\/orcid.org\/0000-0002-7879-8441\">http:\/\/orcid.org\/0000-0002-7879-8441<\/a><\/p><p><strong>\u00a0<\/strong><\/p><p><strong>Selected Research Support <\/strong><\/p><p><strong>PI Coordinator<\/strong>: Assessing the polygenic burden of rare disruptive mutations in Parkinson&#8217;s disease: a novel diagnostic test to predict Parkinson&#8217;s disease risk. Prog n. RF-2019-12370224, funded by the Ministry of Health (Ricerca Finalizzata 2019).<\/p><p><strong>Co-PI<\/strong>: Genomica Funzionale di malattie genetiche rare: Realizzazione di strumenti innovativi ad alto potere diagnostico. (2019-2022) Prog n. F\/050011\/01\/X32, funded \u00a0by MISE.<\/p><p><strong>Co-PI<\/strong>: Approccio multidisciplinare per la realizzazione di protocolli diagnostici per la predizione precoce di predisposizione al morbo di Parkinson (2014-2018) Invitalia \u2013 Agenzia per lo sviluppo.<\/p><p><strong>Co-PI<\/strong> : Realizzazione di strumenti diagnostici per l&#8217;analisi precoce del morbo di Parkinson attraverso l&#8217;identificazione di profili genetici di rischio (2015-2018) MISE \u2013 Ministry of Economic Development.<\/p><p><strong>Unit Participant<\/strong>: Dissecting the molecular mechanism of skeletal neoplastic conditions associated with Paget&#8217;s disease of bone (2014-2017) AIRC<\/p><p><strong>Principal Investigator<\/strong>: Genetic analysis and genotype-phenotype correlations of an extended Italian family with late onset glycogen storage disease tipe II (Pompe disease). (2013-2016) Genzyme-Sanofi Company<\/p><p><strong>Unit Participant<\/strong>: Genetics and Pharmacogenetics of Paget&#8217;s Disease of Bone. (2011-2013) Telethon Project GGP11119<\/p><p><strong>Principal Investigator<\/strong>: Sequencing and Bioinformatics analysis of two Australian patients affected by Focal Segmental Glomerulosclerosis. (2011). Genomics Research Centre, School of Medical Science, Griffith University, Queensland Australia<\/p><p><strong>Unit Participant<\/strong>: Griffith University, Australia, project: An international strategy to identify the genes involved in Migraine. (Period: 2009-2011).<\/p>                    <\/div>\n\t\t        \n                    <div id=\"research-group-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"research-group-tab\">\n\t\t\t\t        <p><div class=\"tmm tmm_research-group-t-esposito\"><div class=\"tmm_2_columns tmm_wrap tmm_plugin_f\"><span class=\"tmm_two_containers_tablet\"><\/span><div class=\"tmm_container\"><div class=\"tmm_member\" style=\"border-top:#006293 solid 5px;\"><div class=\"tmm_photo tmm_pic_research-group-t-esposito_0\" style=\"background: url(https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/02\/DSC_0255.jpg); margin-left: auto; margin-right:auto; background-size:cover !important;\"><\/div><div class=\"tmm_textblock\"><div class=\"tmm_names\"><span class=\"tmm_fname\">Giorgio<\/span> <span class=\"tmm_lname\">Fortunato<\/span><\/div><div class=\"tmm_job\">PhD student of the University of Campania L.Vanvitelli and IGB-CNR fellow<\/div><div class=\"tmm_desc\" style=\"text-align:\"><p><strong><img decoding=\"async\" class=\"alignnone wp-image-2318\" src=\"http:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona.png\" alt=\"\" width=\"17\" height=\"17\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona.png 512w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-300x300.png 300w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-150x150.png 150w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-270x250.png 270w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-510x510.png 510w\" sizes=\"(max-width: 17px) 100vw, 17px\" \/><\/strong> +390816132221&nbsp; <img decoding=\"async\" class=\"alignnone wp-image-2317\" src=\"http:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png\" alt=\"\" width=\"19\" height=\"19\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png 512w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-300x300.png 300w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-150x150.png 150w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-270x250.png 270w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-510x510.png 510w\" sizes=\"(max-width: 19px) 100vw, 19px\" \/> giorgio.fortunato@igb.cnr.it<\/p><p><strong>Project Title:<\/strong> Development of innovative diagnostic protocols for the prediction, progression and monitoring of Parkinson\u2019s disease<\/p><\/div><div class=\"tmm_scblock\"><\/div><\/div><\/div><div class=\"tmm_member\" style=\"border-top:#006293 solid 5px;\"><div class=\"tmm_photo tmm_pic_research-group-t-esposito_1\" style=\"background: url(https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2022\/02\/palomba.png); margin-left: auto; margin-right:auto; background-size:cover !important;\"><\/div><div class=\"tmm_textblock\"><div class=\"tmm_names\"><span class=\"tmm_fname\">Nicole Piera<\/span> <span class=\"tmm_lname\">Palomba<\/span><\/div><div class=\"tmm_job\">PostDoc at the IGB-CNR laboratory at IRCCS INM Neuromed<\/div><div class=\"tmm_desc\" style=\"text-align:\"><p><img decoding=\"async\" class=\"alignnone wp-image-2317\" src=\"http:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png\" alt=\"\" width=\"19\" height=\"19\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png 512w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-300x300.png 300w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-150x150.png 150w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-270x250.png 270w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-510x510.png 510w\" sizes=\"(max-width: 19px) 100vw, 19px\" \/> nicole.palomba.89@gmail.com<\/p><p><strong>Project Title: <\/strong>Study of genetic factors underlying neurodegenerative diseases<\/p><\/div><div class=\"tmm_scblock\"><\/div><\/div><\/div><span class=\"tmm_two_containers_tablet\"><\/span><\/div><span class=\"tmm_columns_containers_desktop\"><\/span><div class=\"tmm_container\"><div class=\"tmm_member\" style=\"border-top:#006293 solid 5px;\"><div class=\"tmm_photo tmm_pic_research-group-t-esposito_2\" style=\"background: url(https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/11\/images.png); margin-left: auto; margin-right:auto; background-size:cover !important;\"><\/div><div class=\"tmm_textblock\"><div class=\"tmm_names\"><span class=\"tmm_fname\">Immacolata<\/span> <span class=\"tmm_lname\">Damiano<\/span><\/div><div class=\"tmm_job\">Undergraduate student<\/div><div class=\"tmm_desc\" style=\"text-align:\"><p><img decoding=\"async\" class=\"alignnone wp-image-2317\" src=\"http:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png\" alt=\"\" width=\"19\" height=\"19\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png 512w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-300x300.png 300w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-150x150.png 150w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-270x250.png 270w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-510x510.png 510w\" sizes=\"(max-width: 19px) 100vw, 19px\" \/> immacolata.damiano@igb.cnr.it<\/p><p><strong>Project Title:<\/strong> study of the TMEM175 mutations associated with Parkinson&#8217;s disease<\/p><\/div><div class=\"tmm_scblock\"><\/div><\/div><\/div><div class=\"tmm_member\" style=\"border-top:#006293 solid 5px;\"><div class=\"tmm_photo tmm_pic_research-group-t-esposito_3\" style=\"background: url(https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/11\/images.png); margin-left: auto; margin-right:auto; background-size:cover !important;\"><\/div><div class=\"tmm_textblock\"><div class=\"tmm_names\"><span class=\"tmm_fname\">Federica<\/span> <span class=\"tmm_lname\">Marino<\/span><\/div><div class=\"tmm_desc\" style=\"text-align:\"><p><img decoding=\"async\" class=\"alignnone wp-image-2317\" src=\"http:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png\" alt=\"\" width=\"19\" height=\"19\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png 512w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-300x300.png 300w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-150x150.png 150w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-270x250.png 270w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-510x510.png 510w\" sizes=\"(max-width: 19px) 100vw, 19px\" \/> federica.marino@igb.cnr.it<\/p><p><strong>Project Title:<\/strong> to be defined<\/p><\/div><div class=\"tmm_scblock\"><\/div><\/div><\/div><div style=\"clear:both;\"><\/div><\/div><\/div><\/div><\/p>                    <\/div>\n\t\t                    <\/div>\n        <\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Teresa Esposito Senior Researcher +39 081 6132330-258 \u00a0 \u00a0 teresa.esposito@igb.cnr.it Genetics, Genomics and Epigenetics of Diseases\/ Neuroscience Keywords: Genetics of human diseases, Molecular bases of Parkinson\u2019s disease Orcid Research Interest Selected Publications Professional Experience Research Group The project of our research group aims at the identification of novel biomarkers for early prediction and progression of [&hellip;]<\/p>\n","protected":false},"author":88,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"class_list":["post-2474","page","type-page","status-publish","czr-hentry"],"_links":{"self":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages\/2474","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/users\/88"}],"replies":[{"embeddable":true,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/comments?post=2474"}],"version-history":[{"count":25,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages\/2474\/revisions"}],"predecessor-version":[{"id":15978,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages\/2474\/revisions\/15978"}],"wp:attachment":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/media?parent=2474"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}