{"id":2498,"date":"2021-03-02T13:10:48","date_gmt":"2021-03-02T12:10:48","guid":{"rendered":"https:\/\/www.igb.cnr.it\/?page_id=2498"},"modified":"2025-03-27T11:17:39","modified_gmt":"2025-03-27T10:17:39","slug":"amelia-cimmino","status":"publish","type":"page","link":"https:\/\/www.igb.cnr.it\/index.php\/amelia-cimmino\/","title":{"rendered":"Amelia Cimmino"},"content":{"rendered":"\t\t
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Amelia Cimmino<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Senior Researcher<\/span><\/strong><\/h3>

\"\" +39 081 6132 304 \u00a0 \u00a0\"\" amelia.cimmino@igb.cnr.it<\/strong><\/p>

Molecular Oncology<\/strong><\/p>

Keywords:<\/strong> ncRNA, T-UCR, Cancer, bladder cancer, oncourology
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  • \n \n \n \n Research Interest<\/span> <\/li>\n
  • \n \n \n \n Selected Publications<\/span> <\/li>\n
  • \n \n \n \n Professional Experience<\/span> <\/li>\n
  • \n \n \n \n Research Group<\/span> <\/li>\n <\/ul>\n <\/div>\n \n
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    The concept that small non-coding RNAs namely miRNAs, are involved in tumorigenesis, particularly in chronic lymphocytic leukemia (CLL) was pioneered during the last few years, in the laboratory of Dr. Croce. As an active member of this group, I contributed to the identification of an important miRNA-related mechanism of leukemogenesis, by discovering that the Bcl2 protein was a target of miRs 15a-16-1. This study was fundamental for the understanding of CLL pathogenesis and has fostered the development of a drug capable to cure CLL. Very recently, a specific BCL2 inhibitor ABT-199 (Venetoclax) was developed and approved by FDA for CLL treatment.\u00a0 In 2007 we also provided the evidence \u00a0that another family of ncRNAs named ultraconserved genes (UCGs) are involved in human cancers and directly interact with miRNAs .My research is now based on the identification of a panel of \u00a0transcribed ultraconserved RNA \u00a0(T-UCRs) having \u00a0distinct \u201cpeaks\u201d of expression in low- and high-grade Bladder cancer (BlCa) tissues\u00a0 that will be able to recognize all histotypes of bladder cancer. The selected panel\u00a0 can be detected – and precisely quantified using digital real time\u00a0 on the tumor cells exfoliate in the urine samples. Then, with the measure\u00a0 of T-UCRs biomarkers in urine , we will provide\u00a0 an\u00a0 approach based on a non-invasive, easy to perform, rapid and and accurate test to be widely used in clinical practice for early detection and follow-up of BlCa.\u00a0<\/p>

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    Terreri S, Mancinelli S, Ferro M, Vitale MC, Perdon\u00e0 S, Castaldo L, Gigantino V, Mercadante V, De Cecio R, Aquino G, Montella M, Angelini C, Del Prete E, Aprile M, Ciaramella A, Liguori GL, Costa V, Calin GA, La Civita E, Terracciano D, Febbraio F, Cimmino A<\/strong>. Subcellular Localization of uc.8+ as a Prognostic Biomarker in Bladder Cancer Tissue. Cancers (Basel). 2021 Feb 8;13(4):681. doi: 10.3390\/cancers13040681. PMID: 33567603; PMCID: PMC7914980.<\/p>

    Vannini I, Wise PM, Challagundla KB, Plousiou M, Raffini M, Bandini E, Fanini F, Paliaga G, Crawford M, Ferracin M, Ivan C, Fabris L, Davuluri RV, Guo Z, Cortez MA, Zhang X, Chen L, Zhang S, Fernandez-Cymering C, Han L, Carloni S, Salvi S, Ling H, Murtadha M, Neviani P, Gitlitz BJ, Laird-Offringa IA, Nana-Sinkam P, Negrini M, Liang H, Amadori D, Cimmino A,<\/strong> Calin GA,\u00a0Fabbri M.\u00a0 \u201cTranscribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs.\u201d Nature communications vol. 8,1 1801. 27 Nov. 2017, doi:10.1038\/s41467-017-01562-9<\/p>

    Fabbri M, Bottoni A, Shimizu M, Spizzo R, Nicoloso MS, Rossi S, Barbarotto E, Cimmino A<\/strong>, Adair B, Wojcik SE, Valeri N, Calore F, Sampath D, Fanini F, Vannini I, Musuraca G, Dell’Aquila M, Alder H, Davuluri RV, Rassenti LZ, Negrini M, Nakamura T, Amadori D, Kay NE, Rai KR, Keating MJ, Kipps TJ,\u00a0Calin G*, Croce CM*.\u00a0Association of a microRNA\/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia.\u00a0JAMA. 2011 Jan 5;305(1):59-67. doi: 10.1001\/jama.2010.1919. PubMed PMID: 21205967.\u00a0The identification of a complex network of miRNAs and coding genes influencing the natural history of the most frequent type of leukemia in the western World.<\/p>

    Calin G, Ferracin M, Cimmino A<\/strong>, Di Leva G, Shimizu M, Wojcik SE, Iorio MV, Visone R, Sever NI, Fabbri M, Iuliano R, Palumbo T, Pichiorri F, Roldo C, Garzon R, Sevignani C, Rassenti L, Alder H, Volinia S, Liu CG, Kipps TJ, Negrini M, Croce CM.\u00a0 A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia.\u00a0N Engl J Med.\u00a02005 Oct 27;353(17):1793-801. PubMed PMID: 16251535.\u00a0The discovery of germline mutations located in the cluster miR-15a\/16 in human cancers, including familial cases with CLL and breast cancers.Calin G, Liu CG, Ferracin M, Hyslop T, Spizzo R, Sevignani C, Fabbri M, Cimmino A, Lee EJ, Wojcik SE, Shimizu M, Tili E, Rossi S, Taccioli C, Pichiorri F, Liu X, Zupo S, Herlea V, Gramantieri L, Lanza G, Alder H, Rassenti L, Volinia S, Schmittgen TD, Kipps TJ, Negrini M, Croce CM.\u00a0 Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas.\u00a0Cancer Cell.\u00a02007 Sep;12(3):215-29. PubMed PMID: 17785203.\u00a0The identification of a new family of non-codingRNAs involved in cancers – the ultraconserved genes, that did not change sequence in hundreds of millions of years of evolution.<\/p>

    Cimmino, Amelia<\/strong> et al. \u201cmiR-15 and miR-16 induce apoptosis by targeting BCL2.\u201d Proceedings of the National Academy of Sciences of the United States of America vol. 102,39 (2005): 13944-9. doi:10.1073\/pnas.0506654102. This study was fundamental for the understanding of chronic lymphocytic leukemia (CLL) pathogenesis and has fostered the development of a drug capable to cure CLL. Very recently, a specific BCL2 inhibitor ABT-199 (Venetoclax) was developed and approved by FDA for CLL treatment.<\/p> <\/div>\n\t\t \n

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    31\/October\/1996<\/p>

    M.D. Degree from School of Medicine and Surgery, Federico II University, Naples<\/p>

    1996-2000<\/p>

    Residency and Specialization Degree in Clinical Chemistry and Biochemistry and Molecular Biology. School of Medicine and Surgery, S.U.N., Italy.\u00a0<\/p>

    21 \/ December \/2004<\/p>

    Attending doctorate program in Cellular Biochemistry at the Second University of Naples. Department of Biochemistry and Biophysics.\u00a0<\/p>

    2003-2004 \u00a0\u00a0<\/p>

    Post- doctoral \u00a0research fellow \u00a0at \u00a0the \u201cKimmel Cancer Center \u201cof the \u00a0\u201c Thomas Jefferson University \u201c, \u00a0Philadelphia, PA, in the labs \u00a0of Prof. Carlo Maria Croce.\u00a0<\/p>

    2004-2007\u00a0<\/p>

    Post-doctoral Researcher in Prof. Carlo Croce\u2019 s labs, at the Dep. of Molecular Virology, Immunology and Medical Genetic of The Comprehensive Cancer Center, Ohio State University, Columbus, OH.\u00a0<\/p>

    AWARDS<\/p>

    2006-2008 American-Italian Cancer Foundation Fellowship for the project entitled: \u201cMicroRNAs involvement in \u00a0Familiar CLL\u201dat the Second University of Naples. Department of Biochemistry and Biophysics.<\/p>

    2009- 2011\u00a0<\/p>

    Fellowship by Fondazione Italiana per la Ricerca \u00a0sul Cancro (FIRC), with a project entitled: \u201cRegulatory interaction between AP-1 and \u00a0microRNAs\u201d at Dr. Verde\u2019s Lab of Molecular Oncology, \u00a0Institute of Genetics and Biophysics (CNR, Naples) \u00a0<\/p>

    2011-2014\u00a0<\/p>

    GRANTS AWARDED: Ultraconserved Region Encoding ncRNAs involvement in Bladder tumors , Associazione Italiana per la Ricerca sul Cancro (AIRC).<\/p>

    28-10-2021<\/p>

    Start Cup Campania (2021) prize for translating basic research to enterprise for the project URiNBB- Urinary RNA Noncoding Bladder cancer Biomarker.<\/p> <\/div>\n\t\t \n

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    <\/span>
    <\/div>
    Mario<\/span> Russo<\/span><\/div>
    Undergraduate student<\/div>

    Project Title:<\/strong> Identification of the biological function of Transcribed Ultraconserved regions in bladder cancer<\/p><\/div>

    <\/div><\/div><\/div>
    <\/div>
    Anna<\/span> Mirra<\/span><\/div>
    Undergraduate student<\/div>

    Project Title: <\/strong>Cancer specific Transcribed Ultraconserved long noncoding RNA  in bladder cancer<\/p><\/div>

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    <\/div><\/div><\/div><\/div> <\/div>\n\t\t <\/div>\n <\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

    Amelia Cimmino Senior Researcher +39 081 6132 304 \u00a0 \u00a0 amelia.cimmino@igb.cnr.it Molecular Oncology Keywords: ncRNA, T-UCR, Cancer, bladder cancer, oncourology Research Interest Selected Publications Professional Experience Research Group The concept that small non-coding RNAs namely miRNAs, are involved in tumorigenesis, particularly in chronic lymphocytic leukemia (CLL) was pioneered during the last few years, in the […]<\/p>\n","protected":false},"author":80,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"class_list":["post-2498","page","type-page","status-publish","czr-hentry"],"_links":{"self":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages\/2498","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/users\/80"}],"replies":[{"embeddable":true,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/comments?post=2498"}],"version-history":[{"count":25,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages\/2498\/revisions"}],"predecessor-version":[{"id":18252,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages\/2498\/revisions\/18252"}],"wp:attachment":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/media?parent=2498"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}