{"id":2599,"date":"2021-03-03T11:31:50","date_gmt":"2021-03-03T10:31:50","guid":{"rendered":"https:\/\/www.igb.cnr.it\/?page_id=2599"},"modified":"2023-09-20T14:26:46","modified_gmt":"2023-09-20T12:26:46","slug":"maria-matarazzo","status":"publish","type":"page","link":"https:\/\/www.igb.cnr.it\/index.php\/maria-matarazzo\/","title":{"rendered":"Maria Matarazzo"},"content":{"rendered":"\t\t
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\n\t\t\t\t\t\t\t\"DSC_0094\"\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t<\/div>\n\n\t\t\t\n\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Maria R. Matarazzo<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Research Director<\/span><\/strong><\/h3>

\"\"+39 081 6132426\u00a0\u00a0\"\" maria.matarazzo@igb.cnr.it<\/strong><\/p>

Genetics, Genomics and Epigenetics of Diseases<\/strong><\/p>

Keywords: <\/strong>Epigenetics, Stem cell identity, DNA methylation, human iPSCs, Primary Immunodeficiencies, Rare disease, CRISPR\/Cas9 gene editing<\/p><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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  • \n \n \n \n Research Interest<\/span> <\/li>\n
  • \n \n \n \n Selected Publications<\/span> <\/li>\n
  • \n \n \n \n Professional Experience<\/span> <\/li>\n
  • \n \n \n \n Research Group<\/span> <\/li>\n <\/ul>\n <\/div>\n \n
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    Epigenetic control of cellular identity and function in human disorders<\/p>

    In our laboratory we study the role of DNA methylation and the epigenetic modifications in the assembly and maintenance of transcriptional and chromatin domains. How they are perturbed in pathological conditions, such as in primary immunodeficiencies caused by epigenetic regulators (DNMT3B, KMT2D, <\/em>KDM6A<\/em>), is the major issue that we are currently addressing. This group of diseases includes ultra-rare and rare genetic disease, like ICF and Kabuki syndromes (KS).<\/p>

    Our experimental strategy combines classic molecular approaches and gene-specific analysis with large-scale transcriptomic and epigenomic technologies in human cellular models, in particular patient-derived induced pluripotent stem cells (iPSCs).\u00a0\u00a0\u00a0\u00a0\u00a0 <\/p>