{"id":8674,"date":"2021-10-14T16:16:23","date_gmt":"2021-10-14T14:16:23","guid":{"rendered":"https:\/\/www.igb.cnr.it\/?page_id=8674"},"modified":"2023-09-20T14:36:17","modified_gmt":"2023-09-20T12:36:17","slug":"laura-pisapia","status":"publish","type":"page","link":"https:\/\/www.igb.cnr.it\/index.php\/laura-pisapia\/","title":{"rendered":"Laura Pisapia"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"8674\" class=\"elementor elementor-8674\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3f8d9090 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3f8d9090\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-562dd848\" data-id=\"562dd848\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-cb13faa elementor-widget elementor-widget-spacer\" data-id=\"cb13faa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-49f6b84f elementor-widget__width-initial elementor-absolute elementor-widget elementor-widget-bdt-member\" data-id=\"49f6b84f\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;none&quot;,&quot;_position&quot;:&quot;absolute&quot;}\" data-widget_type=\"bdt-member.bdt-phaedra\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"bdt-member skin-phaedra bdt-transition-toggle\">\n\t\t\t\n\t\t\t\t<div class=\"bdt-member-photo-wrapper\">\n\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"bdt-member-photo\">\n\t\t\t\t\t\t<div class=\"\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/foto-AIC-Pisapia.jpg\" title=\"foto AIC Pisapia\" alt=\"foto AIC Pisapia\" loading=\"lazy\" \/>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t<\/div>\n\n\t\t\t\n\t\t\t<div class=\"bdt-member-overlay bdt-overlay-default bdt-position-cover bdt-transition-fade bdt-position-z-index\">\n\t\t\t\t<div class=\"bdt-member-desc bdt-position-center bdt-text-center\">\n\t\t\t\t\t<div class=\"bdt-member-content bdt-transition-slide-top-small\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"bdt-member-icons bdt-transition-slide-bottom-small\">\n\t\t\t\t\t\t\t<a class=\"bdt-member-icon elementor-repeater-item-888e908\" href=\"https:\/\/www.linkedin.com\/in\/laura-pisapia-91a56a9b\/?originalSubdomain=it\" target=\"_blank\" data-bdt-tooltip=\"title: Linkedin;\">\n\t\t\t\t\t<i aria-hidden=\"true\" class=\"fa-fw fab fa-linkedin-in\"><\/i>\t\t\t\t<\/a>\n\t\t\t\t\t\t<\/div>\n\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-2589cee6\" data-id=\"2589cee6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-63bd047c elementor-widget elementor-widget-heading\" data-id=\"63bd047c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Laura Pisapia<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6b56188 elementor-widget elementor-widget-text-editor\" data-id=\"6b56188\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3><strong><span style=\"color: #006293;\">Researcher<\/span><\/strong><\/h3><div><p><strong><img decoding=\"async\" class=\"alignnone wp-image-2318\" src=\"http:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona.png\" alt=\"\" width=\"17\" height=\"17\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona.png 512w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-300x300.png 300w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-150x150.png 150w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-270x250.png 270w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-510x510.png 510w\" sizes=\"(max-width: 17px) 100vw, 17px\" \/> +39 081 6132318\u00a0 \u00a0<img decoding=\"async\" class=\"alignnone wp-image-2317\" src=\"http:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png\" alt=\"\" width=\"19\" height=\"19\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png 512w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-300x300.png 300w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-150x150.png 150w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-270x250.png 270w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-510x510.png 510w\" sizes=\"(max-width: 19px) 100vw, 19px\" \/> laura.pisapia@igb.cnr.it<\/strong><\/p><p><strong>Genetics, Genomics and Epigenetics of Diseases<\/strong><\/p><p><strong>Keywords: <\/strong>Flow Cytometry, Autoimmunity, Celiac disease, HLA genes, Food allergy, Innate and Adaptive immune response, Long non-coding RNA, Post-transcriptional regulation<\/p><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6d7d31c7 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6d7d31c7\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c560d11\" data-id=\"c560d11\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-227d6887 elementor-widget elementor-widget-eael-adv-tabs\" data-id=\"227d6887\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"eael-adv-tabs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t        <div data-scroll-on-click=\"no\" data-scroll-speed=\"300\" id=\"eael-advance-tabs-227d6887\" class=\"eael-advance-tabs eael-tabs-horizontal eael-tab-auto-active \" data-tabid=\"227d6887\">\n            <div class=\"eael-tabs-nav\">\n                <ul class=\"\" role=\"tablist\">\n                                            <li id=\"research-interest\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"research-interest-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >Research Interest<\/span>                                                    <\/li>\n                                            <li id=\"selected-publications\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"selected-publications-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >Selected Publications<\/span>                                                    <\/li>\n                                            <li id=\"professional-experience\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"false\" data-tab=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"professional-experience-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >Professional Experience<\/span>                                                    <\/li>\n                                    <\/ul>\n            <\/div>\n            \n            <div class=\"eael-tabs-content\">\n\t\t        \n                    <div id=\"research-interest-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"research-interest-tab\">\n\t\t\t\t        <p><strong>Flow citometry: <\/strong><\/p><p>Flow cytometry facility management and scientific supervision. The\u00a0 in-depth knowledge flow citometry\u00a0 allow me\u00a0 to support the research groups\u00a0 in\u00a0 their approach to flow cytometry. In particular \u00a0I collaborate in the experimental design, choice of polychromatic antibody panel, data acquisition and analysis.<\/p><p class=\"elementor-heading-title elementor-size-default\"><a href=\"http:\/\/www.igb.cnr.it\/index.php\/facs\/\">Facs Facility LINK<\/a><\/p><p>\u00a0<\/p><p class=\"elementor-heading-title elementor-size-default\"><strong>Research topics:<\/strong><\/p><ul><li>Study of HLA genes regulation and expression\u00a0 in autoimmune disease such as celiac disease, diabetes and multiple sclerosis.<\/li><li>Identification of new biomarkers in immunoopathogenesis of celiac disease and other autoimmune diseases<\/li><li>Unravelling the pathophysiology of immune tolerance in food allergies and intolerances in collaboration with the &#8220;Immunonutrition lab&#8221; at Federico II University.<\/li><li>Analysis of PA2G4 pseudogene 4 (PA2G4P4): identification of sequence and functions in bladder carcinoma and glioblastoma.<\/li><\/ul>                    <\/div>\n\t\t        \n                    <div id=\"selected-publications-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"selected-publications-tab\">\n\t\t\t\t        <p>Farina F. ,<strong>Pisapia L<\/strong>., Laezza M., Serena G., Rispo A., Ricciolino S., Gianfrani C., Fasano A., Del Pozzo, G.<\/p><p>Effect of Gliadin Stimulation on HLA-DQ2 . 5 Gene Expression in Macrophages from Adult Celiac Disease Patients. Biomedicines\u00a0 2022, 10 (1):63<\/p><p><a href=\"https:\/\/doi.org\/10.3390\/biomedicines10010063\">https:\/\/doi.org\/10.3390\/biomedicines10010063<\/a><\/p><p>Paparo L, Nocerino R, Ciaglia E, Di Scala C, De Caro C, Russo R, Trinchese G, Aitoro R, Amoroso A, Bruno C, Di Costanzo M, Passariello A, Messina F, Agangi A, Napolitano M, Voto L, Gatta GD, <strong>Pisapia<\/strong> <strong>L<\/strong>, Montella F, Mollica MP, Calignano A, Puca A, Berni Canani R.<\/p><p>Butyrate as a bioactive human milk protective component against food allergy.<\/p><p>Allergy. 2021 May;76(5):1398-1415. doi: 10.1111\/all.14625. Epub 2020 Nov 16.<\/p><p>PMID: 33043467<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33043467\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/33043467\/<\/a><\/p><p>Paparo L, Picariello G, Bruno C, <strong>Pisapia L<\/strong>, Canale V, Sarracino A, Nocerino R, Carucci L, Cosenza L, Cozzolino T, Berni Canani R.<\/p><p>Tolerogenic Effect Elicited by Protein Fraction Derived From Different Formulas for Dietary Treatment of Cow&#8217;s Milk Allergy in Human Cells.<\/p><p>Front Immunol. 2021 Feb 12;11:604075. doi: 10.3389\/fimmu.2020.604075. eCollection 2020.<\/p><p>PMID: 33679694<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33679694\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/33679694\/<\/a><\/p><p><strong>Pisapia L<\/strong>., Picascia S., Farina F., Barba P., Gianfrani C., Del Pozzo G<strong>.<\/strong>, Differential expression of predisposing HLA-DQ2.5 alleles in DR5\/DR7 celiac disease patients affects the pathological immune response to gluten. Scientific Reports 2020 Oct 14;10(1):17227.<\/p><p>doi: 10.1038\/s41598-020-73907-2.<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33057065\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/33057065\/<\/a><\/p><p><strong>\u00a0<\/strong><\/p><p><strong>Pisapia L<\/strong>, Terreri S, Barba P, Mastroianni M, Donnini M, Mercadante V, Palmieri A, Verze P, Mirone V, Altieri V, Califano G, Liguori GL, Strazzullo M, Cimmino A, Del Pozzo G<\/p><p>Role of PA2G4P4 pseudogene in bladder cancer tumorigenesis<\/p><p>Biology, 2020 Mar 31;9(4):66. doi: 10.3390\/biology9040066.<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32244410\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/32244410\/<\/a><\/p><p>Paparo L,Tripodi L, Bruno C, <strong>Pisapia L<\/strong>, Damiano C, Pastore L, Berni Canani R<\/p><p>Protective action of Bacillus clausii probiotic strains in an in vitro model of Rotavirus infection<\/p><p>\u00a0Sci Rep, 2020 Jul 28;10(1):12636. doi: 10.1038\/s41598-020-69533-7<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32724066\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/32724066\/<\/a><\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31313885\/\">The HLA-DRB1 risk alleles for multiple sclerosis are differentially expressed in blood cells of patients from Southern Italy.<\/a><\/p><p><strong>Pisapia L<\/strong>, Cerillo I, Farina F, Zimbardo A, Barba P, Orefice G, Gianfrani C, Strazzullo M, Del Pozzo G.Int J Immunogenet. 2019 Dec;46(6):479-484. doi: 10.1111\/iji.12450. Epub 2019 Jul 17.PMID:\u00a031313885<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31313885\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/31313885\/<\/a><\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31817224\/\">Tristetraprolin\/ZFP36 Regulates the Turnover of Autoimmune-Associated HLA-DQ mRNAs.<\/a><\/p><p><strong>Pisapia L<\/strong>, Hamilton RS, Farina F, D&#8217;Agostino V, Barba P, Strazzullo M, Provenzani A, Gianfrani C, Del Pozzo G.Cells. 2019 Dec 4;8(12):1570. doi: 10.3390\/cells8121570.PMID:\u00a031817224<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31817224\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/31817224\/<\/a><\/p><p>Farina F., Picascia S., <strong>Pisapia L<\/strong>., Barba P., Vitale S., Franzese A., Mozzillo E., Gianfrani C., <strong>Del Pozzo \u00a0\u00a0\u00a0G.<\/strong>, HLA-DQA1 and HLA-DQB1 Alleles, Conferring Susceptibility to Celiac Disease and Type 1 Diabetes, are \u00a0\u00a0\u00a0More Expressed Than Non-Predisposing Alleles and are Coordinately Regulated. Cells 2019 Jul 19;8(7):751.<\/p><p>\u00a0doi: 10.3390\/cells8070751.<\/p><p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31331105\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31331105<\/a><\/p><p><strong>Pisapia L<\/strong>., Camarca A., Picascia S., Bassi V., Barba P., <strong>Del Pozzo G.,<\/strong> Gianfrani C., HLA-DQ2.5 genes \u00a0\u00a0\u00a0associated with celiac disease risk are preferentially expressed with respect to non-predisposing HLA genes: Implication for anti-gluten T cell response. Journal of Autoimmunity 2016 Jun;70:63-72.<\/p><p>\u00a0doi: 10.1016\/j.jaut.2016.03.016<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27083396\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/27083396\/<\/a><\/p>                    <\/div>\n\t\t        \n                    <div id=\"professional-experience-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"professional-experience-tab\">\n\t\t\t\t        <p><strong>Current Position<\/strong><\/p><ul><li>2020 &#8211; Research Scientist and scientific supervisor of\u00a0 Flow cytometry facility at IGB-ABT, CNR, Naples, Italy<\/li><\/ul><p><strong>Research Training<\/strong><\/p><ul><li>2018-2020 Post-doc at \u00a0Immunonutrition lab of Prof.Roberto Berni Canani, dipartimento di Scienze Mediche e Traslazionali , Universit\u00e0 di Napoli Federico II<\/li><li>2017-2018 Researcher at IRBM Science Park<\/li><li>2007-2017 co-responsible of\u00a0 Flow cytometry facility at IGB-ABT, CNR, Naples, Italy<\/li><li>2010-2017 Post doc at IGB-ABT, CNR, Naples, Italy<\/li><li>2007-2010 PhD student at IGB-ABT, CNR, Naples, Italy<\/li><li>2006 -2007 Fellow at Regional Center for Education (GEAR), University of Naples \u201cFederico II\u201d, Napoli, Italy<\/li><li>2005-2006 Fellow at IGB-ABT<\/li><li>Undergraduate student at IGB-ABT, CNR, Naples, Italy<\/li><\/ul><p><strong>Education<\/strong><\/p><ul><li>2015 admission of admission to the national register of expert in cytometry, sponsored by the Italian Society of Cytometry (GIC)<\/li><li>2010 PhD in Advanced biology, University of Naples \u201cFederico II\u201d, Italy<\/li><li>2005 B.A. in Biology, University of Naples \u201cFederico II\u201d, Italy<\/li><\/ul><p><strong>Funded Research Projects<\/strong><\/p><ul><li>Fondazione Italiana Celiachia 2021<\/li><\/ul>                    <\/div>\n\t\t                    <\/div>\n        <\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Laura Pisapia Researcher +39 081 6132318\u00a0 \u00a0 laura.pisapia@igb.cnr.it Genetics, Genomics and Epigenetics of Diseases Keywords: Flow Cytometry, Autoimmunity, Celiac disease, HLA genes, Food allergy, Innate and Adaptive immune response, Long non-coding RNA, Post-transcriptional regulation Research Interest Selected Publications Professional Experience Flow citometry: Flow cytometry facility management and scientific supervision. The\u00a0 in-depth knowledge flow citometry\u00a0 allow [&hellip;]<\/p>\n","protected":false},"author":70,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"class_list":["post-8674","page","type-page","status-publish","czr-hentry"],"_links":{"self":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages\/8674","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/users\/70"}],"replies":[{"embeddable":true,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/comments?post=8674"}],"version-history":[{"count":34,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages\/8674\/revisions"}],"predecessor-version":[{"id":16030,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages\/8674\/revisions\/16030"}],"wp:attachment":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/media?parent=8674"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}