{"id":9979,"date":"2021-10-25T18:05:48","date_gmt":"2021-10-25T16:05:48","guid":{"rendered":"https:\/\/www.igb.cnr.it\/?page_id=9979"},"modified":"2023-09-20T14:50:50","modified_gmt":"2023-09-20T12:50:50","slug":"enza-lonardo","status":"publish","type":"page","link":"https:\/\/www.igb.cnr.it\/index.php\/enza-lonardo\/","title":{"rendered":"Enza Lonardo"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"9979\" class=\"elementor elementor-9979\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-60b2cabd elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"60b2cabd\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-5ded2908\" data-id=\"5ded2908\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4e7db7d3 elementor-widget elementor-widget-bdt-member\" data-id=\"4e7db7d3\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;none&quot;}\" data-widget_type=\"bdt-member.bdt-phaedra\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"bdt-member skin-phaedra bdt-transition-toggle\">\n\t\t\t\n\t\t\t\t<div class=\"bdt-member-photo-wrapper\">\n\n\t\t\t\t\t\n\t\t\t\t\t<div class=\"bdt-member-photo\">\n\t\t\t\t\t\t<div class=\"\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/10\/DSC_0235.jpg\" title=\"DSC_0235\" alt=\"DSC_0235\" loading=\"lazy\" \/>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t<\/div>\n\n\t\t\t\n\t\t\t<div class=\"bdt-member-overlay bdt-overlay-default bdt-position-cover bdt-transition-fade bdt-position-z-index\">\n\t\t\t\t<div class=\"bdt-member-desc bdt-position-center bdt-text-center\">\n\t\t\t\t\t<div class=\"bdt-member-content bdt-transition-slide-top-small\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-11140dd\" data-id=\"11140dd\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1e5b141 elementor-widget elementor-widget-heading\" data-id=\"1e5b141\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Enza Lonardo<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3e593fa7 elementor-widget elementor-widget-text-editor\" data-id=\"3e593fa7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3><strong><span style=\"color: #006293;\">Researcher<\/span><\/strong><\/h3><div><p><strong>\u00a0<img decoding=\"async\" class=\"alignnone wp-image-2318\" src=\"http:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona.png\" alt=\"\" width=\"17\" height=\"17\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona.png 512w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-300x300.png 300w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-150x150.png 150w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-270x250.png 270w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-510x510.png 510w\" sizes=\"(max-width: 17px) 100vw, 17px\" \/> +39 081 6132423 \u00a0 <img decoding=\"async\" class=\"alignnone wp-image-2317\" src=\"http:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png\" alt=\"\" width=\"19\" height=\"19\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png 512w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-300x300.png 300w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-150x150.png 150w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-270x250.png 270w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-510x510.png 510w\" sizes=\"(max-width: 19px) 100vw, 19px\" \/> enza.lonardo@igb.cnr.it<\/strong><\/p><p><strong>Molecular Oncology<\/strong><\/p><p><strong>Keywords: <\/strong>Pancreatic cancer, colorectal cancer, tumour microenvironment, 3D culture, TGFbeta signaling, nanomedicine<\/p><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3a81f5c e-grid-align-left elementor-shape-rounded elementor-grid-0 elementor-widget elementor-widget-social-icons\" data-id=\"3a81f5c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"social-icons.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-social-icons-wrapper elementor-grid\" role=\"list\">\n\t\t\t\t\t\t\t<span class=\"elementor-grid-item\" role=\"listitem\">\n\t\t\t\t\t<a class=\"elementor-icon elementor-social-icon elementor-social-icon-twitter elementor-animation-grow-rotate elementor-repeater-item-6344322\" href=\"https:\/\/twitter.com\/enzalonardo1\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-screen-only\">Twitter<\/span>\n\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fab fa-twitter\"><\/i>\t\t\t\t\t<\/a>\n\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<span class=\"elementor-grid-item\" role=\"listitem\">\n\t\t\t\t\t<a class=\"elementor-icon elementor-social-icon elementor-social-icon- elementor-animation-grow-rotate elementor-repeater-item-021f1e1\" href=\"https:\/\/scholar.google.com\/citations?user=qxLDOzYAAAAJ\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-screen-only\"><\/span>\n\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"#000000\" viewBox=\"0 0 50 50\" width=\"100px\" height=\"100px\"><path d=\"M 25 2 C 12.309534 2 2 12.309534 2 25 C 2 37.690466 12.309534 48 25 48 C 37.690466 48 48 37.690466 48 25 C 48 12.309534 37.690466 2 25 2 z M 25 4 C 36.609534 4 46 13.390466 46 25 C 46 36.609534 36.609534 46 25 46 C 13.390466 46 4 36.609534 4 25 C 4 13.390466 13.390466 4 25 4 z M 21 11 L 11 20 L 17.78125 20 C 17.80125 22.847 19.967531 25.730469 23.769531 25.730469 C 24.129531 25.730469 24.529688 25.690391 24.929688 25.650391 C 24.749688 26.100391 24.560547 26.470078 24.560547 27.080078 C 24.560547 28.230078 25.140391 28.920078 25.650391 29.580078 C 24.020391 29.690078 20.989766 29.879531 18.759766 31.269531 C 16.629766 32.559531 15.980469 34.43 15.980469 35.75 C 15.980469 38.47 18.500469 41 23.730469 41 C 29.930469 41 33.220703 37.510547 33.220703 34.060547 C 33.220703 31.530547 31.779453 30.279922 30.189453 28.919922 L 28.900391 27.890625 C 28.500391 27.570625 27.949219 27.120312 27.949219 26.320312 C 27.949219 25.510313 28.500703 24.989766 28.970703 24.509766 C 30.480703 23.309766 32 21.960234 32 19.240234 C 32 18.197234 31.756203 17.348391 31.408203 16.650391 L 35 13.570312 L 35 17.277344 C 34.405 17.623344 34 18.261 34 19 L 34 25 C 34 26.104 34.896 27 36 27 C 37.104 27 38 26.104 38 25 L 38 19 C 38 18.262 37.595 17.624344 37 17.277344 L 37 12 C 37 11.957 36.980609 11.920906 36.974609 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data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-61c686ef elementor-widget elementor-widget-eael-adv-tabs\" data-id=\"61c686ef\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"eael-adv-tabs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t        <div data-scroll-on-click=\"no\" data-scroll-speed=\"300\" id=\"eael-advance-tabs-61c686ef\" class=\"eael-advance-tabs eael-tabs-horizontal eael-tab-auto-active \" data-tabid=\"61c686ef\">\n            <div class=\"eael-tabs-nav\">\n                <ul class=\"\" role=\"tablist\">\n                                            <li id=\"research-interest\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"research-interest-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >Research Interest<\/span>                                                    <\/li>\n                                            <li id=\"selected-publications\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"selected-publications-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >Selected Publications<\/span>                                                    <\/li>\n                                            <li id=\"professional-experience\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"false\" data-tab=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"professional-experience-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >Professional Experience<\/span>                                                    <\/li>\n                                            <li id=\"research-group\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"false\" data-tab=\"4\" role=\"tab\" tabindex=\"-1\" aria-controls=\"research-group-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >Research Group<\/span>                                                    <\/li>\n                                    <\/ul>\n            <\/div>\n            \n            <div class=\"eael-tabs-content\">\n\t\t        \n                    <div id=\"research-interest-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"research-interest-tab\">\n\t\t\t\t        <p>Genetic alterations underlying the metastatic dissemination processes have not been identified thus far. Therefore, it is currently not possible to discriminate which patients are at higher risk of developing metastasis or to design targeted therapies to prevent this process. The main goal of my research is to increase survival of pancreatic and colorectal cancer patients by exploring the contribution of the tumour microenvironment to the failure of presently available oncological treatments.<\/p>                    <\/div>\n\t\t        \n                    <div id=\"selected-publications-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"selected-publications-tab\">\n\t\t\t\t        <p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34302422\/\">SERS Quantification of Galunisertib Delivery in Colorectal Cancer Cells by Plasmonic-Assisted Diatomite Nanoparticles.<\/a> Manag\u00f2 S, Tramontano C, Delle Cave D, Chianese G, Zito G, De Stefano L, Terracciano M,\u00a0<strong>Lonardo E<\/strong>, De Luca AC, Rea I.Small. 2021 Aug;17(34):e2101711. doi: 10.1002\/smll.202101711. Epub 2021 Jul 24.PMID:\u00a034302422<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33897875\/\">Nodal-induced L1CAM\/CXCR4 subpopulation sustains tumor growth and metastasis in colorectal cancer derived organoids.<\/a> Cave DD, Hernando-Momblona X, Sevillano M, Minchiotti G,\u00a0<strong>Lonardo E.<\/strong>Theranostics. 2021 Mar 31;11(12):5686-5699. doi: 10.7150\/thno.54027. eCollection 2021.PMID:\u00a033897875\u00a0<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33672435\/\">The Revolutionary Roads to Study Cell-Cell Interactions in 3D In Vitro Pancreatic Cancer Models.<\/a> Delle Cave D, Rizzo R, Sainz B Jr, Gigli G, Del Mercato LL,\u00a0<strong>Lonardo E.<\/strong>Cancers (Basel). 2021 Feb 23;13(4):930. doi: 10.3390\/cancers13040930.PMID:\u00a033672435\u00a0<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32576846\/\">A synergic approach to enhance long-term culture and manipulation of MiaPaCa-2 pancreatic cancer spheroids.<\/a> Cavo M, Delle Cave D, D&#8217;Amone E, Gigli G,\u00a0<strong>Lonardo E<\/strong>, Del Mercato LL.Sci Rep. 2020 Jun 23;10(1):10192. doi: 10.1038\/s41598-020-66908-8.PMID:\u00a032576846\u00a0<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32291413\/\">TGF-\u03b21 secreted by pancreatic stellate cells promotes stemness and tumourigenicity in pancreatic cancer cells through L1CAM downregulation.<\/a> Cave DD, Di Guida M, Costa V, Sevillano M, Ferrante L, Heeschen C, Corona M, Cucciardi A,\u00a0<strong>Lonardo E.<\/strong>Oncogene. 2020 May;39(21):4271-4285. doi: 10.1038\/s41388-020-1289-1. Epub 2020 Apr 14.PMID:\u00a032291413\u00a0<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28085225\/\">Determinants of metastatic competency in colorectal cancer.<\/a> Tauriello DV, Calon A,\u00a0<strong>Lonardo E<\/strong>, Batlle E.Mol Oncol. 2017 Jan;11(1):97-119. doi: 10.1002\/1878-0261.12018. Epub 2017 Jan 3.PMID:\u00a028085225\u00a0<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26132091\/\">Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies.<\/a> <strong>Lonardo E<\/strong>, Cioffi M, Sancho P, Crusz S, Heeschen C.J Vis Exp. 2015 Jun 20;(100):e52801. doi: 10.3791\/52801.PMID:\u00a026132091\u00a0<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25887381\/\">The miR-17-92 cluster counteracts quiescence and chemoresistance in a distinct subpopulation of pancreatic cancer stem cells.<\/a> Cioffi M, Trabulo SM, Sanchez-Ripoll Y, Miranda-Lorenzo I,\u00a0<strong>Lonardo E<\/strong>, Dorado J, Reis Vieira C, Ramirez JC, Hidalgo M, Aicher A, Hahn S, Sainz B Jr, Heeschen C.Gut. 2015 Dec;64(12):1936-48. doi: 10.1136\/gutjnl-2014-308470. Epub 2015 Apr 17.PMID:\u00a025887381\u00a0<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25706628\/\">Stromal gene expression defines poor-prognosis subtypes in colorectal cancer.<\/a> Calon A,\u00a0<strong>Lonardo E<\/strong>, Berenguer-Llergo A, Espinet E, Hernando-Momblona X, Iglesias M, Sevillano M, Palomo-Ponce S, Tauriello DV, Byrom D, Cortina C, Morral C, Barcel\u00f3 C, Tosi S, Riera A, Attolini CS, Rossell D, Sancho E, Batlle E.Nat Genet. 2015 Apr;47(4):320-9. doi: 10.1038\/ng.3225. Epub 2015 Feb 23.PMID:\u00a025706628<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25262208\/\"><br \/>Intracellular autofluorescence: a biomarker for epithelial cancer stem cells.<\/a> Miranda-Lorenzo I, Dorado J,\u00a0<strong>Lonardo E<\/strong>, Alcala S, Serrano AG, Clausell-Tormos J, Cioffi M, Megias D, Zagorac S, Balic A, Hidalgo M, Erkan M, Kleeff J, Scarpa A, Sainz B Jr, Heeschen C.Nat Methods. 2014 Nov;11(11):1161-9. doi: 10.1038\/nmeth.3112. Epub 2014 Sep 28.PMID:\u00a025262208<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24204632\/\">Metformin targets the metabolic achilles heel of human pancreatic cancer stem cells.<\/a> <strong>Lonardo E<\/strong>, Cioffi M, Sancho P, Sanchez-Ripoll Y, Trabulo SM, Dorado J, Balic A, Hidalgo M, Heeschen C.PLoS One. 2013 Oct 18;8(10):e76518. doi: 10.1371\/journal.pone.0076518. eCollection 2013.PMID:\u00a024204632\u00a0<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22421149\/\">Pancreatic stellate cells form a niche for cancer stem cells and promote their self-renewal and invasiveness.<\/a> <strong>Lonardo E<\/strong>, Frias-Aldeguer J, Hermann PC, Heeschen C.Cell Cycle. 2012 Apr 1;11(7):1282-90. doi: 10.4161\/cc.19679. Epub 2012 Apr 1.PMID:\u00a022421149<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22056140\/\">Nodal\/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy.<\/a> <strong>Lonardo E<\/strong>, Hermann PC, Mueller MT, Huber S, Balic A, Miranda-Lorenzo I, Zagorac S, Alcala S, Rodriguez-Arabaolaza I, Ramirez JC, Torres-Ru\u00edz R, Garcia E, Hidalgo M, Cebri\u00e1n D\u00c1, Heuchel R, L\u00f6hr M, Berger F, Bartenstein P, Aicher A, Heeschen C.Cell Stem Cell. 2011 Nov 4;9(5):433-46. doi: 10.1016\/j.stem.2011.10.001.PMID:\u00a022056140<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21698355\/\">Pancreatic cancer stem cells: new insights and perspectives.<\/a> Dorado J,\u00a0<strong>Lonardo E<\/strong>, Miranda-Lorenzo I, Heeschen C.J Gastroenterol. 2011 Aug;46(8):966-73. doi: 10.1007\/s00535-011-0422-x. Epub 2011 Jun 23.PMID:\u00a021698355\u00a0Review.<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20580623\/\">Pancreatic cancer stem cells &#8211; update and future perspectives.<\/a> <strong>Lonardo E<\/strong>, Hermann PC, Heeschen C.Mol Oncol. 2010 Oct;4(5):431-42. doi: 10.1016\/j.molonc.2010.06.002. Epub 2010 Jun 9.PMID:\u00a020580623\u00a0<\/p>                    <\/div>\n\t\t        \n                    <div id=\"professional-experience-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"professional-experience-tab\">\n\t\t\t\t        <p><strong>February 12<sup>nd<\/sup> 2017<\/strong> \u2013 <strong>present:<\/strong> <u>Head <\/u>of Gastrointestinal Cancer Laboratory at the Institute of Genetics and Biophysics \u201cA. Buzzati Traverso\u201d (IGB, Naples, Italy)<\/p><p><strong>\u00a0<\/strong><strong>November 1<sup>st<\/sup> 2012<\/strong> \u2013 <strong>31<sup>st<\/sup> January 2017:<\/strong> <u>Postdoctoral fellow<\/u> in Colorectal Cancer Laboratory led by Prof. Eduard Batlle at Institute for Research in Biomedicine (IRB, Barcelona, Spain)<\/p><p><strong>May 1<sup>st<\/sup> 2009- April 30<sup>rd<\/sup> 2012<\/strong>:\u00a0 <u>Postdoctoral fellow<\/u> in Stem Cells and Cancer Research Group led by Prof. Christopher Heeschen at Spanish National Cancer Research Center (CNIO, Madrid, Spain)<\/p><p><strong>January 12<sup>nd<\/sup> 2008- April 30<sup>th<\/sup>\u00a0 2009<\/strong>: <u>Postdoctoral fellow<\/u> in the group of Dr. Gabriella Minchiotti at the Institute of Genetics and Biophysics \u201cA. Buzzati Traverso\u201d (IGB, Naples, Italy)<\/p><p><strong>2004-2008<\/strong>:\u00a0 <u>PhD student<\/u> in the group of Dr. Gabriella Minchiotti at the Institute of Genetics and Biophysics \u201cA. Buzzati Traverso\u201d (IGB, Naples, Italy)<\/p><p><strong>2001-2003<\/strong>:\u00a0 <u>Master Student<\/u> in the group of Dr. Roderto Defez at the Institute of Genetics and Biophysics \u201cA. Buzzati Traverso\u201d (IGB, Naples, Italy)<\/p>                    <\/div>\n\t\t        \n                    <div id=\"research-group-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"research-group-tab\">\n\t\t\t\t        <p><div class=\"tmm tmm_research-group-lonardo\"><div class=\"tmm_2_columns tmm_wrap tmm_plugin_f\"><span class=\"tmm_two_containers_tablet\"><\/span><div class=\"tmm_container\"><div class=\"tmm_member\" style=\"border-top:#006293 solid 5px;\"><a target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.igb.cnr.it\/index.php\/donatella-delle-cave\/\" title=\"Donatella Delle Cave\"><div class=\"tmm_photo tmm_pic_research-group-lonardo_0\" style=\"background: url(https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2025\/03\/dellecave-2.jpg); margin-left: auto; margin-right:auto; background-size:cover !important;\"><\/div><\/a><div class=\"tmm_textblock\"><div class=\"tmm_names\"><span class=\"tmm_fname\">Donatella<\/span> <span class=\"tmm_lname\">Delle Cave<\/span><\/div><div class=\"tmm_job\">Researcher<\/div><div class=\"tmm_desc\" style=\"text-align:\"><p><strong><img decoding=\"async\" class=\"alignnone wp-image-2318\" src=\"http:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona.png\" alt=\"\" width=\"17\" height=\"17\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona.png 512w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-300x300.png 300w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-150x150.png 150w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-270x250.png 270w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/Telefono-icona-510x510.png 510w\" sizes=\"(max-width: 17px) 100vw, 17px\" \/><\/strong> +39 0816132412\u00a0 <strong><img decoding=\"async\" class=\"alignnone wp-image-2317\" src=\"http:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png\" alt=\"\" width=\"19\" height=\"19\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png 512w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-300x300.png 300w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-150x150.png 150w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-270x250.png 270w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-510x510.png 510w\" sizes=\"(max-width: 19px) 100vw, 19px\" \/><\/strong> donatella.dellecave@igb.cnr.it<\/p><p><strong>Project Title:<\/strong> Unraveling the role of cancer-derived collagen in metastatic pancreatic ductal adenocarcinoma<\/p><\/div><div class=\"tmm_scblock\"><\/div><\/div><\/div><div class=\"tmm_member\" style=\"border-top:#006293 solid 5px;\"><div class=\"tmm_photo tmm_pic_research-group-lonardo_1\" style=\"background: url(https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/11\/images.png); margin-left: auto; margin-right:auto; background-size:cover !important;\"><\/div><div class=\"tmm_textblock\"><div class=\"tmm_names\"><span class=\"tmm_fname\">Annalisa<\/span> <span class=\"tmm_lname\">Di Domenico<\/span><\/div><div class=\"tmm_job\">Research fellow<\/div><div class=\"tmm_desc\" style=\"text-align:\"><p>\u00a0<strong><img decoding=\"async\" class=\"alignnone wp-image-2317\" src=\"http:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png\" alt=\"\" width=\"19\" height=\"19\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png 512w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-300x300.png 300w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-150x150.png 150w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-270x250.png 270w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-510x510.png 510w\" sizes=\"(max-width: 19px) 100vw, 19px\" \/><\/strong> annalisa.didomenico@igb.cnr.it<\/p><p><strong>Project Title:<\/strong> Overcoming cancer therapeutic bottleneck by drug repurposing<\/p><\/div><div class=\"tmm_scblock\"><\/div><\/div><\/div><span class=\"tmm_two_containers_tablet\"><\/span><\/div><span class=\"tmm_columns_containers_desktop\"><\/span><div class=\"tmm_container\"><div class=\"tmm_member\" style=\"border-top:#006293 solid 5px;\"><div class=\"tmm_photo tmm_pic_research-group-lonardo_2\" style=\"background: url(https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/11\/Teresa-Pirozzi.jpeg); margin-left: auto; margin-right:auto; background-size:cover !important;\"><\/div><div class=\"tmm_textblock\"><div class=\"tmm_names\"><span class=\"tmm_fname\">Teresa<\/span> <span class=\"tmm_lname\">Pirozzi<\/span><\/div><div class=\"tmm_job\">Undergraduate student <\/div><div class=\"tmm_desc\" style=\"text-align:\"><p>\u00a0<strong><img decoding=\"async\" class=\"alignnone wp-image-2317\" src=\"http:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png\" alt=\"\" width=\"19\" height=\"19\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png 512w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-300x300.png 300w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-150x150.png 150w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-270x250.png 270w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-510x510.png 510w\" sizes=\"(max-width: 19px) 100vw, 19px\" \/><\/strong> teresa.pirozzi@igb.cnr.it<\/p><p><strong>Project Title:<\/strong> Characterization and development of heterotypic 3D cultures of pancreatic cancer cells<\/p><\/div><div class=\"tmm_scblock\"><\/div><\/div><\/div><div class=\"tmm_member\" style=\"border-top:#006293 solid 5px;\"><div class=\"tmm_photo tmm_pic_research-group-lonardo_3\" style=\"background: url(https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/11\/Ilaria-Di-Biase.jpeg); margin-left: auto; margin-right:auto; background-size:cover !important;\"><\/div><div class=\"tmm_textblock\"><div class=\"tmm_names\"><span class=\"tmm_fname\">Ilaria<\/span> <span class=\"tmm_lname\">Di Biase<\/span><\/div><div class=\"tmm_job\">Undergraduate student <\/div><div class=\"tmm_desc\" style=\"text-align:\"><p>\u00a0<strong><img decoding=\"async\" class=\"alignnone wp-image-2317\" src=\"http:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png\" alt=\"\" width=\"19\" height=\"19\" srcset=\"https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona.png 512w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-300x300.png 300w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-150x150.png 150w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-270x250.png 270w, https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/02\/email-icona-510x510.png 510w\" sizes=\"(max-width: 19px) 100vw, 19px\" \/><\/strong> ilaria.dibiase@igb.cnr.it<\/p><p><strong>Project Title:<\/strong> Metabolic characterization of pancreatic cancer stem cells<\/p><\/div><div class=\"tmm_scblock\"><\/div><\/div><\/div><span class=\"tmm_two_containers_tablet\"><\/span><\/div><span class=\"tmm_columns_containers_desktop\"><\/span><div class=\"tmm_container\"><div class=\"tmm_member\" style=\"border-top:#006293 solid 5px;\"><div class=\"tmm_photo tmm_pic_research-group-lonardo_4\" style=\"background: url(https:\/\/www.igb.cnr.it\/wp-content\/uploads\/2021\/11\/member-1-1-1-1-1.svg); margin-left: auto; margin-right:auto; background-size:cover !important;\"><\/div><div class=\"tmm_textblock\"><div class=\"tmm_names\"><span class=\"tmm_fname\">Hasnaa<\/span> <span class=\"tmm_lname\">A. Elfawy<\/span><\/div><div class=\"tmm_job\">PhD candidate<\/div><div class=\"tmm_desc\" style=\"text-align:\"><p><strong>Project Title:<\/strong> Targeted drug delivery in colorectal cancer cells: cancer treatments strengthening by nanomedicine<\/p><\/div><div class=\"tmm_scblock\"><\/div><\/div><\/div><div style=\"clear:both;\"><\/div><\/div><\/div><\/div><\/p><p>\u00a0<\/p>                    <\/div>\n\t\t                    <\/div>\n        <\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Enza Lonardo Researcher \u00a0 +39 081 6132423 \u00a0 enza.lonardo@igb.cnr.it Molecular Oncology Keywords: Pancreatic cancer, colorectal cancer, tumour microenvironment, 3D culture, TGFbeta signaling, nanomedicine Twitter Linkedin Wix External-link-square-alt Research Interest Selected Publications Professional Experience Research Group Genetic alterations underlying the metastatic dissemination processes have not been identified thus far. Therefore, it is currently not possible to [&hellip;]<\/p>\n","protected":false},"author":31,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"class_list":["post-9979","page","type-page","status-publish","czr-hentry"],"_links":{"self":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages\/9979","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/users\/31"}],"replies":[{"embeddable":true,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/comments?post=9979"}],"version-history":[{"count":52,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages\/9979\/revisions"}],"predecessor-version":[{"id":16073,"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/pages\/9979\/revisions\/16073"}],"wp:attachment":[{"href":"https:\/\/www.igb.cnr.it\/index.php\/wp-json\/wp\/v2\/media?parent=9979"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}