Dott. Nicolas Rivron – Blastoids: modeling mouse and human blastocyst development and implantation with stem cells.
25 set 2023, 12:00–13:00 (Europe/Amsterdam)
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Biography: Nicolas Rivron is a developmental biologist and tissue engineer. He leads the laboratory for blastoid development and implantation at the Institute for Molecular Biotechnologies, from the Austrian Academy of Science (Vienna, Austria). His laboratory created a model of the pre-implantation embryo formed through the self-organization of stem cells, which they called blastoid. This embryo model implants in utero, when formed with mouse stem cells, and recapitulates aspects of implantation into in vitro cultured uterine cells, when formed with human stem cells. His laboratory investigates the basic principles of self-organization and is interested in contributing to solving global health problems related to fertility decline, family planning, and the developmental origin of health and diseases.

The blastocyst is the early mammalian organism before implantation. We have figured out how to promote the self-organization of stem cells into models of the mouse and human blastocysts, which we have named blastoids (Nature 2018, Nature 2021). Blastoids are morphologically and transcriptionally similar to the blastocyst and contain analogs of all three cell types that would eventually develop into the complete organism (embryonic and extraembryonic tissues). Because blastoids are complete and model the preimplantation stage, they can be introduced into the uterus (mouse model) or combined in vitro with uterine cells (human model) to recapitulate aspects of the normally hidden implantation processes. Unlike blastocysts, blastoids come in large numbers and facilitate the more systematic modulation and analysis of the impact of cell numbers, states, and communication mechanisms on development. As such, they represent both a scientific and ethical alternative to the use of embryos for research. Using this approach, we are investigating the rules of multicellular interaction underlying species-specific aspects of blastocyst development and implantation, with the long-term goal of contributing to solving the global health problems of fertility decline, family planning, and developmental origin of health and disease.