This course will provide an introduction to next generation sequencing platforms, data analysis and tools for data quality control, including alignment to a reference sequence, data handling and visualisation, and variant calling and filtering (single nucleotide polymorphisms and structural variants). The course will be delivered using a mixture of lectures and computer based hands-on practical sessions, including mini-projects to be completed by the participants using the knowledge gained at the course. Projects will cover the general topics of population structure and admixture, demographic changes and natural selection.
This course is aimed at PhD students and post-doctoral researchers who are applying, or will apply in the near future, high throughput sequencing technologies and the related bioinformatics tools in their research.
Participants with limited UNIX/Linux and R/Bioconductor experience will be provided with basic understanding of the command-line operations and the foundations of the R programming language on the first day of the course.