My research focuses on the molecular mechanisms underlying embryonic development, with particular emphasis on the transcription factor TBX1 and its role embryo development and 22q11.2 deletion syndrome. Using Tbx1 mutant mouse models and stem-cell–based systems, I have demonstrated that TBX1 regulates cardiovascular differentiation by modulating multiple signaling pathways, including FGF8 response, Vegfr2 repression, and tissue regionalization. More recently, I identified vitamin B12 as a potential therapeutic agent capable of partially rescuing developmental and metabolic defects in Tbx1 mutants, restoring brain metabolomic balance and correcting associated behavioral phenotypes. These findings highlight a novel link between TBX1 dosage, metabolism, and gut development. Currently my research is aimed to: (1) identify the signals regulating tissue regionalisation during gut embryogenesis in Tbx1 mutant; (2) define how these cues shape the gut environment, with the ultimate goal of uncovering new therapeutic strategies for congenital disorders.