The Multifaceted Roles of Proline in Cell Behavior. Patriarca EJ, Cermola F, D'Aniello C, Fico A, Guardiola O, De Cesare D, Minchiotti G. Front Cell Dev Biol. 2021 Aug 12;9:728576.

Gastruloid Development Competence Discriminates Different States of Pluripotency. Cermola F, D'Aniello C, Tatè R, De Cesare D, Martinez-Arias A, Minchiotti G, Patriarca EJ. Stem Cell Reports. 2021 Feb 9;16(2):354-369.

Proline Metabolism in Tumor Growth and Metastatic Progression. D'Aniello C, Patriarca EJ, Phang JM, Minchiotti G. Front Oncol. 2020 May 15;10:776.

Collagen Prolyl Hydroxylation-Dependent Metabolic Perturbation Governs Epigenetic Remodeling and Mesenchymal Transition in Pluripotent and Cancer Cells. D'Aniello C, Cermola F, Palamidessi A, Wanderlingh LG, Gagliardi M, Migliaccio A, Varrone F, Casalino L, Matarazzo MR, De Cesare D, Scita G, Patriarca EJ, Minchiotti G. Cancer Res. 2019 Jul 1;79(13):3235-3250.

Metabolic-Epigenetic Axis in Pluripotent State Transitions. D'Aniello C, Cermola F, Patriarca EJ, Minchiotti G. Epigenomes. 2019 Jul 31;3(3):13.

Vitamin C in Stem Cell Biology: Impact on Extracellular Matrix Homeostasis and Epigenetics. D'Aniello C, Cermola F, Patriarca EJ, Minchiotti G. Stem Cells Int. 2017;2017:8936156.

Vitamin C and l-Proline Antagonistic Effects Capture Alternative States in the Pluripotency Continuum. D'Aniello C, Habibi E, Cermola F, Paris D, Russo F, Fiorenzano A, Di Napoli G, Melck DJ, Cobellis G, Angelini C, Fico A, Blelloch R, Motta A, Stunnenberg HG, De Cesare D, Patriarca EJ, Minchiotti G. Stem Cell Reports. 2017 Jan 10;8(1):1-10.

Cripto is essential to capture mouse epiblast stem cell and human embryonic stem cell pluripotency. Fiorenzano A, Pascale E, D'Aniello C, Acampora D, Bassalert C, Russo F, Andolfi G, Biffoni M, Francescangeli F, Zeuner A, Angelini C, Chazaud C, Patriarca EJ, Fico A, Minchiotti G. Nat Commun. 2016 Sep 2;7:12589. 

A novel autoregulatory loop between the Gcn2-Atf4 pathway and l-Proline metabolism controls stem cell identity. D'Aniello C, Fico A, Casalino L, Guardiola O, Di Napoli G, Cermola F, De Cesare D, Tatè R, Cobellis G, Patriarca EJ, Minchiotti G. Cell Death Differ. 2015 Jul;22(7):1234.

Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome. Bellin M, Casini S, Davis RP, D'Aniello C, Haas J, Ward-van Oostwaard D, Tertoolen LG, Jung CB, Elliott DA, Welling A, Laugwitz KL, Moretti A, Mummery CL. EMBO J. 2013 Dec 11;32(24):3161-75.

Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: disease mechanisms and pharmacological rescue. Zhang M, D'Aniello C, Verkerk AO, Wrobel E, Frank S, Ward-van Oostwaard D, Piccini I, Freund C, Rao J, Seebohm G, Atsma DE, Schulze-Bahr E, Mummery CL, Greber B, Bellin M. Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):E5383-92.

The G-protein-coupled receptor APJ is expressed in the second heart field and regulates Cerberus-Baf60c axis in embryonic stem cell cardiomyogenesis. D'Aniello C, Fiorenzano A, Iaconis S, Liguori GL, Andolfi G, Cobellis G, Fico A, Minchiotti G. Cardiovasc Res. 2013 Oct 1;100(1):95-104.

G protein-coupled receptor APJ and its ligand apelin act downstream of Cripto to specify embryonic stem cells toward the cardiac lineage through extracellular signal-regulated kinase/p70S6 kinase signaling pathway. D'Aniello C, Lonardo E, Iaconis S, Guardiola O, Liguoro AM, Liguori GL, Autiero M, Carmeliet P, Minchiotti G. Circ Res. 2009 Jul 31;105(3):231-8.

EDUCATION AND DEGREE

Jan 2011          PhD in Genetics and Molecular Medicine. University “Federico II” of Naples, Italy

Dec 2006          Master’s degree (summa cum laude) in Medical Biotechnology. University “Federico II” of                    Naples, Italy.

Feb 2005          Bachelor’s degree (110/110) in Biotechnology. University “Federico II” of Naples, Italy.

RESEARCH EXPERIENCE AND PROFESSIONAL APPOINTMENTS

Jul 2019-present          CNR Research Scientist, IGB-CNR, Naples, Italy.

Sept 2018-Jul 2019       Temporary CNR Research Scientist, IGB-CNR, Naples, Italy.

Feb 2014-Sept 2018     Senior Post-Doctoral fellow, IGB-CNR, Naples, Italy.

May 2014-Jun 2014      Visiting fellow, Leiden University Medical Centre (LUMC), Leiden, Netherlands.

May 2012-Dec 2013     Post-Doctoral fellow, LUMC, Leiden, Netherlands.

Jan 2012-Apr 2012       EMBO short-term fellow (ASTF 387.00-2011), LUMC, Leiden, Netherlands.

Dec 2010-Dec 2011      Post-Doctoral fellow, IGB-CNR, Naples, Italy.

Nov 2007-Nov 2010     PhD fellow, IGB-CNR, Naples, Italy.

Jan 2007-Oct 2007       Pre-doctoral fellow, IGB-CNR, Naples, Italy.

May 2005-Dec 2006     Undergraduate student (Master thesis), IGB-CNR, Naples, Italy.

Feb 2004-Feb 2005       Undergraduate student (Bachelor thesis), University “Federico II” of Naples, Italy.

FELLOWSHIPS AND AWARDS

Jul 2018: InterOmics Grant to attend the EMBO Workshop “From Epigenome towards Epitranscriptome in Cell Fate Choice”, October 14-17, 2018, Capri, Italy.

May 2015: Epigen Travel Grant to attend the “Annual Meeting of International Society for Stem Cell Research (ISSCR)”, June 24-27, 2015, Stockholm, Sweden.

Feb 2015: Marie Curie Individual fellowship (Standard EF). Call H2020-MSCA-IF-2014_ST (Proposal number 657398). The project received a total score of 85% (Threshold 70%). However it was not funded given the budgetary resources available under the call.

Dec 2014: ABCD Travel Grant to attend the Cell Biology of Disease: Cancer (CBDC) meeting”, November 28-29, 2014, Parma, Italy.

Oct 2011: EMBO short-term fellowship (ASTF 387.00-2011) to visit the laboratory of Prof. C.L. Mummery, LUMC, Leiden, Netherlands.

June 2010: Poster Prize received at the National Meeting of PhD students, June 10-12, 2010, Gubbio, Italy.

Sept 2009: Poster Prize received at V European Summer School in “Stem Cells & Regenerative Medicine” EuroSystem, Sept 19-25, 2009, Hydra, Greece.

Nov 2007: PhD fellowship of the University “Federico II” of Naples, Italy.

SUPERVISION OF STUDENTS

2019-present: Supervisor of two master students working on theses in Molecular Biology, University “Federico II” of Naples, Italy.

2007-present: Co-Supervisor of six master students working on theses in Developmental Biology, University “Federico II” of Naples, Italy. Co-Supervisor of one pre-doctoral fellow and one technician, IGB-CNR, Naples, Italy. Supervisor of one Erasmus master student, LUMC, Leiden, Netherlands.

TEACHING ACTIVITIES

2007-2011: Teacher and Lecturer at the annual “Stem Cell Training Course” (Editions II-VI), IGB-CNR, Naples, Italy.

DISSEMINATION AND OUTREACH ACTIVITIES

Nov 2020: Futuro Remoto, IGB-CNR, Naples, Italy.

Nov 2019: Futuro Remoto Science Centre, Città della Scienza, Naples, Italy.

May 2019: Fattorie Didattiche Aperte, Istituto Zooprofilattico Sperimentale del Mezzogiorno, Naples, Italy.

Sept 2018: Notte dei Ricercatori, Orto Botanico, Naples, Italy.

May 2017: Futuro Remoto, Science Centre, Città della Scienza, Naples, Italy.

Nov 2014: Open day for students of the secondary school, IGB-CNR, Naples, Italy

2007-2011/2014-present: AIRC fundraising activities, Naples, Italy.

MEMBERSHIPS OF SCIENTIFIC SOCIETIES

2016-present: Società Italiana di Biofisica e Biologia Molecolare (SIBBM).

2015: International Society for Stem Cell Research (ISSCR).

2011-present: Associazione di Biologia Cellulare e del Differenziamento (ABCD).

REVIEWER FOR INTERNATIONAL JOURNALS AND GRANT AGENCIES

2020-present: Referee for International Journals such as Tumor Biology, iScience, Aminoacids.

2020-present: Expert and external Evaluator for COST-Actions

RESEARCH FUNDING (PI)

Dec 2020-Oct 2021: Research Contract with Chiesi Farmaceutici S.p.A (n°10389185). Project Title “Effetto di corticosteroidi sulle transizioni staminali-mesenchimali”.

Nov 2019-June 2020: Research Contract with Chiesi Farmaceutici S.p.A (n°10320531). Project Title “Effetto di corticosteroidi sulle transizioni staminali-mesenchimali”.

RESEARCH FUNDING (Participant)

2018-2023: Associazione Italiana Ricerca sul Cancro (AIRC). Novel strategies to target the acquisition of mesenchymal traits in cancer cells and prevent tumor dissemination (Progetto numero: IG20736).

2015-2019: Unione Europea- H2020-COST-Action. Epigenetic Chemical Biology (EpichemBio) WG2.

2012-2018: Ministero dell'Istruzione, dell'Università e della Ricerca (MIUR)- Consiglio Nazionale delle Ricerche (CNR). Identificazione di trattamenti epigenetici innovative: caratterizzazione e reversibilità di epimutazioni nel cancro.

2011-2014: Associazione Italiana Ricerca sul Cancro (AIRC). Elucidating the basis of EMT in embryonic and cancer stem cells as tool for cancer therapy (Progetto numero: IG 11599).

2008-2010: Associazione Italiana Ricerca sul Cancro (AIRC). Development of new strategies to eliminate the risk of stem cell derived tumor formation (Progetto numero: IG 6128).

PARTICIPATION TO INTERNATIONAL MEETINGS AND COURSES

1. EMBO Workshop “From Epigenome towards Epitranscriptome in Cell Fate Choice”, October 14-17, 2018, Capri, Italy, (poster presentation).
2. Cold Spring Harbor Meeting “Stem Cell Biology”, September 25-29, 2017, Cold Spring Harbor, New York, (poster presentation).
3. ”Annual Meeting of International Society for Stem Cell Research (ISSCR)”, June 24-27, 2015, Stockholm, Sweden, (poster presentation).
4. “EMBO laboratory Management Course”, April 28-30, 2014, Leimen, Germany.
5. 7^th International Meeting, Stem Cell Network North Rhine-Westphalia, April 23-24, 2013, Cologne, Germany.
6. ISD meeting, “Stem Cells, Development and Regulation”, November 5-8, 2012, Amsterdam, Netherlands.
7. “Stem Cells: The diverging goals of regenerative medicine and oncology”, July 1-2, 2010 Rome, Italy, (poster presentation).
8. 22nd IGB Meeting, “Stem Cells: from molecular physiology to therapeutic application”, October 10-13, 2009, Capri, Italy, (poster presentation).
9. V European Summer School in “Stem Cell & Regenerative Medicine” EuroSystem, September 19-25, 2009, Hydra, Greece; (poster presentation).
10. EMBO/IGB Workshop: “Cell migration, Tissue Invasion and Disease”, October 14-17, 2006, Capri, Italy, (poster presentation).

INVITED SPEAKER AT NATIONAL MEETING

SIBBM lecture “Induction of multi- and pluripotent stem cells”, Feb 16, 2018, University “Federico II” of Naples, Italy. Title: “Beyond transcription factors: metabolic control of pluripotent stem cell metastability".

ORAL PRESENTATIONS AT CONFERENCES

• 5th SIBBM Seminar Frontiers in Molecular Biology, June 4-6, 2009, Naples, Italy.
• 8th FISV, Italy, 28 September-1 October, 2006, Riva del Garda.