Valeria Tarallo

Valeria Tarallo

Senior Researcher

+39 081 6132 721

Molecular Oncology

Keywords: Alu RNAs, cancer, angiogenesis, AMD

The main research interests are the study of Alu RNAs in cancer progression and in the dry form of age-related macular degeneration and other pathological disorders and the study of molecular factors of VEGF family members and related receptors involved in physiological and pathological angiogenesis.

Pignata P, Apicella I, Cicatiello V, Puglisi C, Magliacane Trotta S, Sanges R, Tarallo V, De Falco S. Prolyl 3-Hydroxylase 2 Is a Molecular Player of Angiogenesis. Int J Mol Sci. 2021 Apr 9;22(8):3896. doi: 10.3390/ijms22083896. *co-last author

Tarallo V, Iaccarino E, Cicatiello V, Sanna R, Ruvo M and De Falco S. Oral delivery of a tetrameric tripeptide inhibitor of VEGFR1 suppresses pathological choroid neovascularization. Int J Mol Sci. 2020 Jan 9;21(2):410. doi: 10.3390/ijms21020410.

Apicella I, Cicatiello V, Acampora D, Tarallo V*, De Falco S. Full Functional Knockout of Placental Growth Factor by Knockin with an Inactive Variant Able to Heterodimerize with VEGF-A. Cell Rep. 2018 Jun 19;23(12):3635-3646. *co-corresponding author

Di Ruocco F, Basso V, Rivoire M, Mehlen P, Ambati J, De Falco S, Tarallo V* Alu RNA accumulation induces epithelial-to-mesenchymal transition by modulating miR-566 and is associated with cancer progression. Oncogene. 2018 Feb 1;37(5):627-637.

Tarallo V, Hirano Y, Gelfand BD, Dridi S, Kerur N, Kim Y, Cho WG, Kaneko H, Fowler BJ, Bogdanovich S, Albuquerque RJ, Hauswirth WW, Chiodo VA, Kugel JF, Goodrich JA, Ponicsan SL, Chaudhuri G, Murphy MP, Dunaief JL, Ambati BK, Ogura Y, Yoo JW, Lee DK, Provost P, Hinton DR, Núñez G, Baffi JZ, Kleinman ME and Ambati J. DICER1 loss and Alu RNA induce age-related macular degeneration via NLRP3 inflammasome and MyD88. Cell. 2012 May 11;149(4):847-59.

Complete List of Published Work in MyBibliography:

October 2012- present: Researcher at IGB-ABT, CNR, Naples.

January 2010- August 2012: Postdoctoral fellow in the laboratory of Prof. J. Ambati, Department of Ophthalmology and Visual Science, University of Kentucky, Lexington, KY, USA. Topic: Study on the mechanisms involved in the Age-related Macular Degeneration (AMD).

2009: Postdoctoral fellowship, Angiogenesis Lab, IGB-ABT, CNR, Naples, Italy. Topic: New inhibitors of VEGF-dependent angiogenesis associated with ocular neovascular diseases.

2004-2009: PhD fellowship, Angiogenesis Lab, IGB-ABT, CNR, Naples, Italy. Topic: Placental Growth Factor variants for inhibition of VEGF-dependent angiogenesis.

2002-2004: Undergraduate fellow in the laboratory of Dr. Pasquale Verde, IGB-ABT, CNR, Naples, Italy. Topic: Study of the members of AP-1 transcription factor in cancer.

Sara Magliacane Trotta

PhD student

+39 081 6132601

Project Title: Alu RNA as a potential regulator of human gastrointestinal cancer progression and metastatic dissemination