Giovanna Del Pozzo

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Giovanna Del Pozzo

Senior Researcher

+39 081 6132309   giovanna.delpozzo@igb.cnr.it

Genetics, Genomics and Epigenetics of Diseases

Keywords: Autoimmunity , celiac disease, HLA  genes , Adaptive immune response, Pseudogenes in cancer, Post-transcriptional regulation

  • Patent of a new assay for celiac disease diagnosis: A.T.CD4, gliadin activated CD4+ T cells (Rif. CNR 11009 – ID n .2426).
  • Study of HLA class II genes expression in antigen presenting cells from patients affected by autoimmunity.
  • Analysis of the immune response of gliadin-specific CD4+ T lymphocytes in patients with active celiac disease and patients in remission after gluten-free diet.
  • Analysis of immunomodulatory role of exosomes from Mesenchymal Stem Cells
  • Monitoring of antigen-specific CD4+ and CD8+ lymphocyte activation, in patients and healthy donors, following Sars-Cov2 vaccine administration, by flow cytometry immunophenotyping.
  1. S Sartoris, G Del Pozzo. Exploring the HLA complex in autoimmunity: From the risk haplotypes to the modulation of expression. Clinical Immunology Aug.2024. 265, 110266
  2. M Laezza, L Pisapia, B Toro, V Mercadante, A Rispo, C Gianfrani, Del Pozzo. Changes upon the gluten-free diet of HLA-DQ2 and TRAFD1 gene expression in peripheral blood of celiac disease patients. Journal of Translational Autoimmunity. Jun 2014. 8, 100240
  3. Del Mastro A…Del Pozzo and C. Gianfrani. Booster Dose of SARS-CoV-2 mRNA Vaccine in Kidney Transplanted Patients Induces Wuhan-Hu-1 Specific Neutralizing Antibodies and T Cell Activation but Lower Response against Omicron Variant. Viruses May 2023, 15, 1132.
  4. Farina F., Pisapia L., Laezza, MV, Serena G, Rispo A., Ricciolino S, Gianfrani C, Fasano Alessio , Del Pozzo G. Effect of Gliadin Stimulation on HLA-DQ2.5 Gene Expression in Macrophages from Adult Celiac Disease Patients. Biomedicines 2021 Dec 29;10(1):63.
  5. Del Pozzo G., Farina F., Picascia S., Laezza M., Vitale S., Gianfrani C., HLA class II genes in precision-based care of childhood diseases: what we can learn from celiac disease. Pediatric Research 2021, 89, 307–312.
  6. Pisapia L., Picascia S., Farina F., Barba P., Gianfrani C., Del Pozzo G., Differential expression of predisposing HLA-DQ2.5 alleles in DR5/DR7 celiac disease patients affects the pathological immune response to gluten. Scientific Reports 2020, Oct 14;10(1):17227.
  7. Pisapia L., Hamilton R.S., Farina F., D’Agostino V., Barba P.; Strazzullo M., Provenzani A., Gianfrani C., Del Pozzo G., Tristetraprolin/ZFP36 Regulates the Turnover of Autoimmune-Associated HLA-DQ mRNAs. Cells 2019, 8.
  8. Farina F., Picascia S., Pisapia L., Barba P., Vitale S., Franzese A., Mozzillo E., Gianfrani C., Del Pozzo G., HLA-DQA1 and HLA-DQB1 Alleles, Conferring Susceptibility to Celiac Disease and Type 1 Diabetes, are More Expressed Than Non-Predisposing Alleles and are Coordinately Regulated. Cells 2019, 8, 751.
  9. Pisapia L., Cerillo I., Farina F., Zimbardo A., Barba P., Orefice G., Gianfrani C., Strazzullo M., Del Pozzo G., The HLA-DRB1 risk alleles for multiple sclerosis are differentially expressed in blood cells of patients from Southern Italy. International Journal of Immunogenetics 2019, 46, 479–484
  10. Gianfrani C., Pisapia L., Picascia S., Strazzullo M., Del Pozzo G., Expression level of risk genes of MHC class II is a susceptibility factor for autoimmunity: New insights. Journal of Autoimmunity 2018, 89, 1–10.
  11. Pisapia L., Camarca A., Picascia S., Bassi V., Barba P., Del Pozzo G., Gianfrani C., HLA-DQ2.5 genes associated with celiac disease risk are preferentially expressed with respect to non-predisposing HLA genes: Implication for anti-gluten T cell response. Journal of Autoimmunity 2016, 70, 63–72.
  • 1994-2007        CNR Researcher Scientist
  • 2004-present     Immunobiology Group leader  at Institute of Genetics and Biophysics, CNR, Naples
  • 2007–present   CNR Senior Researcher Scientist
  • Reviewer for ISI scientific journals in the field of immunology and molecular biology
  • Supervisor of Master Degree and PhD theses at Federico II University and Luigi Vanvitelli University in  Naples
Laura Pisapia
Researcher

+39 081 6132318    laura.pisapia@igb.cnr.it

Genetics, Genomics and Epigenetics of Diseases

Keywords: Flow Cytometry, Autoimmunity, Celiac disease, HLA genes, Food allergy, Innate and Adaptive immune response, Long non-coding RNA, Post-transcriptional regulation