Eduardo Jorge Patriarca


Eduardo Jorge Patriarca

Research Director

+ 39 081 6132431

Embryonic Development and Biology of Stem Cells

Keywords: Cell Biology/ Stem Cells and Pluripotency/Gastruloids/L-Proline and Metabolism/

In nature, living cells are subjected to a fluctuating environment involving transient or permanent changes in physicochemical parameters such as temperature, salinity and nutrients availability. I study how cells adapt their metabolism to the environmental changes throughout their life, focusing on the interplay between metabolism and cell shape/behavior. My research interest is mainly centered on amino acids and energetic metabolism, which I have been studying over time using different cell systems ranging from bacteria to mammals:

– the dimorphic pathogenic fungus Histoplasma capsulatum that shifts its energetic metabolism during the mycelium-to-yeast morphological transition, which is induced by a temperature shift (25° to 37°C);

– the soil bacterium Rhizobium sp. that modifies its metabolism during the invasion of developing root nodules, specifically the bacteria-to-symbiosome transition that occurs when extracellular bacteria are released inside the cytoplasm of invaded plant cells;

– the pluripotent embryonic stem cells (ESCs) that modify their energetic metabolism during the embryonic stem-to-mesenchymal-like transition (esMT), which is induced by a high proline/low ascorbic acid (vitamin C) regimen.

We are currently investigating the molecular connection between proline metabolism, amino acid starvation (AAR) stress response, and the acquisition of mesenchymal features in stem and cancer cells using 2D and 3D (gastruloids, organoids) cell culture models.

Eduardo Jorge Patriarca has been trained at the Universidad Nacional de La Plata, Argentina, where he graduated in Chemistry and Biochemistry. He served as Secretary-General at the Universidad Nacional de Entre Rìos (AR) in 1986. In 1987 he changed his career path and moved to Italy with a EU granted fellowship to study the heat shock response in the dimorphic pathogenic fungus Histoplasma capsulatum at the International Institute of Genetics and Biophysics (IIGB), where he started his career as CNR Researcher in 1994. Since the very beginning he has been fascinating by how cell morphology changes in response to physicochemical cues from the local environment and how cell metabolism regulates and influences cell plasticity.  Currently, he is research Director at IGB-CNR.

Dario De Cesare
Senior Researcher

+ 39 081 6132315

Embryonic Development and Biology of Stem Cells

Keywords: Stem Cells/Differentiation, Metabolism, Molecular and Cell Biology

Cristina D’Aniello

+ 39 0816132432

Embryonic Development and Biology of Stem Cells

Keywords: Stem Cells/L-Proline and metabolism/EMT and Cancer

Giovanna Ponticelli
Research fellow

+ 390816132432

Project Title: Generation and characterization of lung organoids for the study of Bronchopulmonary dysplasia (BPD)”